Gene expression demonstrates increased resilience toward harmful inflammatory stimuli in the proliferating epidermis of human skin wounds
(2010) In Experimental Dermatology 19(8). p.329-332- Abstract
- We examined the epidermal gene expression during the proliferative phase of wound healing. Matrix metalloproteases were the group of proteases most prominently up-regulated in skin wounds, whereas serine protease inhibitors were the most strongly up-regulated protease inhibitors. Furthermore, we found down-regulation of genes involved in the extrinsic pathway of apoptosis. This together with the up-regulation of inhibitors of leukocyte serine proteases likely represents a protective step to ensure survival of keratinocytes in the inflammatory wound environment. The down-regulation of proapoptotic genes in the extrinsic pathway of apoptosis was not accompanied by a down-regulation of receptors indicating that the keratinocytes in skin... (More)
- We examined the epidermal gene expression during the proliferative phase of wound healing. Matrix metalloproteases were the group of proteases most prominently up-regulated in skin wounds, whereas serine protease inhibitors were the most strongly up-regulated protease inhibitors. Furthermore, we found down-regulation of genes involved in the extrinsic pathway of apoptosis. This together with the up-regulation of inhibitors of leukocyte serine proteases likely represents a protective step to ensure survival of keratinocytes in the inflammatory wound environment. The down-regulation of proapoptotic genes in the extrinsic pathway of apoptosis was not accompanied by a down-regulation of receptors indicating that the keratinocytes in skin wounds did not become less responsive to external stimuli. Examining the transcription factor binding sites in the promoters of the most differentially expressed genes between normal skin and skin wounds a significant overrepresentation of binding sites were found for STAT-5, SRY and members of the FOXO-family of transcription factors. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1654970
- author
- Roupé, Markus LU ; Alberius, Per LU ; Schmidtchen, Artur LU and Sørensen, Ole E LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- transcription factors, inflammation, Apoptosis, gene expression, wound, healing
- in
- Experimental Dermatology
- volume
- 19
- issue
- 8
- pages
- 329 - 332
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000280146200053
- scopus:77954856727
- pmid:20653772
- ISSN
- 0906-6705
- DOI
- 10.1111/j.1600-0625.2009.01038.x
- language
- English
- LU publication?
- yes
- id
- 6849140c-53fd-4b24-9199-8ec0f14c8029 (old id 1654970)
- date added to LUP
- 2016-04-01 09:48:38
- date last changed
- 2025-04-04 14:46:48
@article{6849140c-53fd-4b24-9199-8ec0f14c8029,
abstract = {{We examined the epidermal gene expression during the proliferative phase of wound healing. Matrix metalloproteases were the group of proteases most prominently up-regulated in skin wounds, whereas serine protease inhibitors were the most strongly up-regulated protease inhibitors. Furthermore, we found down-regulation of genes involved in the extrinsic pathway of apoptosis. This together with the up-regulation of inhibitors of leukocyte serine proteases likely represents a protective step to ensure survival of keratinocytes in the inflammatory wound environment. The down-regulation of proapoptotic genes in the extrinsic pathway of apoptosis was not accompanied by a down-regulation of receptors indicating that the keratinocytes in skin wounds did not become less responsive to external stimuli. Examining the transcription factor binding sites in the promoters of the most differentially expressed genes between normal skin and skin wounds a significant overrepresentation of binding sites were found for STAT-5, SRY and members of the FOXO-family of transcription factors.}},
author = {{Roupé, Markus and Alberius, Per and Schmidtchen, Artur and Sørensen, Ole E}},
issn = {{0906-6705}},
keywords = {{transcription factors; inflammation; Apoptosis; gene expression; wound; healing}},
language = {{eng}},
number = {{8}},
pages = {{329--332}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Experimental Dermatology}},
title = {{Gene expression demonstrates increased resilience toward harmful inflammatory stimuli in the proliferating epidermis of human skin wounds}},
url = {{http://dx.doi.org/10.1111/j.1600-0625.2009.01038.x}},
doi = {{10.1111/j.1600-0625.2009.01038.x}},
volume = {{19}},
year = {{2010}},
}