Advanced

Should we Refrain from Performing Oophorectomy in Conjunction with Radical Cystectomy for Bladder Cancer?

Liedberg, Fredrik LU ; Jancke, Georg LU ; Sörenby, Anne and Kannisto, Päivi LU (2017) In European Urology 71(6). p.851-853
Abstract

Radical cystectomy with neoadjuvant chemotherapy is the gold standard for treating muscle-invasive bladder cancer. Women subjected to radical cystectomy are frequently postmenopausal, and the median age for bladder cancer diagnosis in women in Sweden is currently 73 yr (Swedish National Bladder Cancer Register). Traditionally, most women treated with radical cystectomy have undergone simultaneous bilateral oophorectomy and hysterosalpingectomy to diminish the risk of later ovarian disease and ovarian bladder cancer recurrence, but also the belief that there is no impact on health or health-related quality of life associated with oophorectomy and the fact that it might be easier surgery to take the ovarian pedicles, rather than sparing... (More)

Radical cystectomy with neoadjuvant chemotherapy is the gold standard for treating muscle-invasive bladder cancer. Women subjected to radical cystectomy are frequently postmenopausal, and the median age for bladder cancer diagnosis in women in Sweden is currently 73 yr (Swedish National Bladder Cancer Register). Traditionally, most women treated with radical cystectomy have undergone simultaneous bilateral oophorectomy and hysterosalpingectomy to diminish the risk of later ovarian disease and ovarian bladder cancer recurrence, but also the belief that there is no impact on health or health-related quality of life associated with oophorectomy and the fact that it might be easier surgery to take the ovarian pedicles, rather than sparing the ovaries. However, pelvic organ preservation is considered in some younger women to diminish postoperative functional impairment. Based on recent literature in several areas related to oophorectomy, we question the rationale and arguments for performing oophorectomy in women in conjunction with radical cystectomy for bladder cancer. It can be questioned whether routine bilateral oophorectomy during radical cystectomy is advisable in premenopausal women, and the same might also apply to selected postmenopausal women.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Bladder cancer, Ovary, Radical cystectomy
in
European Urology
volume
71
issue
6
pages
851 - 853
publisher
Elsevier
external identifiers
  • scopus:85008957402
  • wos:000400050300009
ISSN
0302-2838
DOI
10.1016/j.eururo.2016.10.010
language
English
LU publication?
yes
id
1654b1af-cb1e-4324-afa8-1953cf63a873
date added to LUP
2017-02-10 12:59:41
date last changed
2018-01-07 11:49:14
@article{1654b1af-cb1e-4324-afa8-1953cf63a873,
  abstract     = {<p>Radical cystectomy with neoadjuvant chemotherapy is the gold standard for treating muscle-invasive bladder cancer. Women subjected to radical cystectomy are frequently postmenopausal, and the median age for bladder cancer diagnosis in women in Sweden is currently 73 yr (Swedish National Bladder Cancer Register). Traditionally, most women treated with radical cystectomy have undergone simultaneous bilateral oophorectomy and hysterosalpingectomy to diminish the risk of later ovarian disease and ovarian bladder cancer recurrence, but also the belief that there is no impact on health or health-related quality of life associated with oophorectomy and the fact that it might be easier surgery to take the ovarian pedicles, rather than sparing the ovaries. However, pelvic organ preservation is considered in some younger women to diminish postoperative functional impairment. Based on recent literature in several areas related to oophorectomy, we question the rationale and arguments for performing oophorectomy in women in conjunction with radical cystectomy for bladder cancer. It can be questioned whether routine bilateral oophorectomy during radical cystectomy is advisable in premenopausal women, and the same might also apply to selected postmenopausal women.</p>},
  author       = {Liedberg, Fredrik and Jancke, Georg and Sörenby, Anne and Kannisto, Päivi},
  issn         = {0302-2838},
  keyword      = {Bladder cancer,Ovary,Radical cystectomy},
  language     = {eng},
  number       = {6},
  pages        = {851--853},
  publisher    = {Elsevier},
  series       = {European Urology},
  title        = {Should we Refrain from Performing Oophorectomy in Conjunction with Radical Cystectomy for Bladder Cancer?},
  url          = {http://dx.doi.org/10.1016/j.eururo.2016.10.010},
  volume       = {71},
  year         = {2017},
}