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Identification of a NK/T cell restricted progenitor in adult bone marrow contributing to bone marrow and thymic-dependent NK cells.

NozadCharoudeh, Hojjatollah LU ; Tang, Yan-Juan LU ; Cheng, Min LU ; Cilio, Corrado LU ; Jacobsen, Sten Eirik W LU and Sitnicka Quinn, Ewa LU (2010) In Blood 116(2). p.183-192
Abstract
Although bone marrow (BM) is the main site of natural killer (NK)-cell development in adult mice, recent studies have identified a distinct thymic-dependent NK pathway, implicating a possible close link between NK- and T-cell development in adult hematopoiesis. To investigate whether a potential NK-/T-lineage restriction of multipotent progenitors might take place already in the BM, we tested the full lineage potentials of NK-cell progenitors in adult BM. Notably, although Lin(-)CD122(+)NK1.1(-)DX5(-) NK-cell progenitors failed to commit to the B and myeloid lineages, they sustained a combined NK- and T-cell potential in vivo and in vitro at the single-cell level. Whereas T-cell development from NK/T progenitors is Notch-dependent, their... (More)
Although bone marrow (BM) is the main site of natural killer (NK)-cell development in adult mice, recent studies have identified a distinct thymic-dependent NK pathway, implicating a possible close link between NK- and T-cell development in adult hematopoiesis. To investigate whether a potential NK-/T-lineage restriction of multipotent progenitors might take place already in the BM, we tested the full lineage potentials of NK-cell progenitors in adult BM. Notably, although Lin(-)CD122(+)NK1.1(-)DX5(-) NK-cell progenitors failed to commit to the B and myeloid lineages, they sustained a combined NK- and T-cell potential in vivo and in vitro at the single-cell level. Whereas T-cell development from NK/T progenitors is Notch-dependent, their contribution to thymic and BM NK cells remains Notch-independent. These findings demonstrate the existence of bipotent NK-/T-cell progenitors in adult BM. (Blood. 2010; 116(2): 183-192) (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Blood
volume
116
issue
2
pages
183 - 192
publisher
American Society of Hematology
external identifiers
  • wos:000279955800008
  • scopus:77955482101
  • pmid:20421450
ISSN
1528-0020
DOI
10.1182/blood-2009-10-247130
language
English
LU publication?
yes
id
80104be4-b728-4006-be43-07a2c58853bc (old id 1657682)
date added to LUP
2010-08-24 11:13:27
date last changed
2018-05-29 12:19:25
@article{80104be4-b728-4006-be43-07a2c58853bc,
  abstract     = {Although bone marrow (BM) is the main site of natural killer (NK)-cell development in adult mice, recent studies have identified a distinct thymic-dependent NK pathway, implicating a possible close link between NK- and T-cell development in adult hematopoiesis. To investigate whether a potential NK-/T-lineage restriction of multipotent progenitors might take place already in the BM, we tested the full lineage potentials of NK-cell progenitors in adult BM. Notably, although Lin(-)CD122(+)NK1.1(-)DX5(-) NK-cell progenitors failed to commit to the B and myeloid lineages, they sustained a combined NK- and T-cell potential in vivo and in vitro at the single-cell level. Whereas T-cell development from NK/T progenitors is Notch-dependent, their contribution to thymic and BM NK cells remains Notch-independent. These findings demonstrate the existence of bipotent NK-/T-cell progenitors in adult BM. (Blood. 2010; 116(2): 183-192)},
  author       = {NozadCharoudeh, Hojjatollah and Tang, Yan-Juan and Cheng, Min and Cilio, Corrado and Jacobsen, Sten Eirik W and Sitnicka Quinn, Ewa},
  issn         = {1528-0020},
  language     = {eng},
  number       = {2},
  pages        = {183--192},
  publisher    = {American Society of Hematology},
  series       = {Blood},
  title        = {Identification of a NK/T cell restricted progenitor in adult bone marrow contributing to bone marrow and thymic-dependent NK cells.},
  url          = {http://dx.doi.org/10.1182/blood-2009-10-247130},
  volume       = {116},
  year         = {2010},
}