Moderate salt restriction effectively lowers blood pressure and degree of salt sensitivity is related to baseline concentration of renin and N-terminal atrial natriuretic peptide in plasma.

Melander, Olle; Wowern, Fredrik; Frandsen, Erik; Burri, Philippe; Willsteen, Gunilla; Aurell, Mattias; Hulthén, Lennart

Moderate salt restriction effectively lowers blood pressure and degree of salt sensitivity is related to baseline concentration of renin and N-terminal atrial natriuretic peptide in plasma.

Mark

; Wowern, Fredrik ^LU ; Frandsen, Erik ; Burri, Philippe ^LU ; Willsteen, Gunilla ; Aurell, Mattias and Hulthén, Lennart ^LU (2007) In Journal of Hypertension 25(3). p.619-627

Abstract: Objective The effect of salt restriction on blood pressure is under intense debate. We tested the effect of 100 mmol salt reduction on ambulatory blood pressure (ABP) in 46 Swedish individuals, 39 of whom completed the study, using a double-blind, placebo-controlled, crossover design. Furthermore, we tested whether the basal plasma concentration of renin or N-terminal atrial natriuretic peptide (Nt-proANP) predict the degree of salt sensitivity. Methods Participants received all meals and drinks with a total daily NaCl content of 50 mmol during 8 weeks. In addition, NaCl capsules (1100 mmol/day) and corresponding placebo capsules were administered for 4 weeks each in random order. ABP after high-salt intake (1150 mmol/day) was compared... (More); Objective The effect of salt restriction on blood pressure is under intense debate. We tested the effect of 100 mmol salt reduction on ambulatory blood pressure (ABP) in 46 Swedish individuals, 39 of whom completed the study, using a double-blind, placebo-controlled, crossover design. Furthermore, we tested whether the basal plasma concentration of renin or N-terminal atrial natriuretic peptide (Nt-proANP) predict the degree of salt sensitivity. Methods Participants received all meals and drinks with a total daily NaCl content of 50 mmol during 8 weeks. In addition, NaCl capsules (1100 mmol/day) and corresponding placebo capsules were administered for 4 weeks each in random order. ABP after high-salt intake (1150 mmol/day) was compared with ABP after low-salt intake (50 mmol/ day). Salt sensitivity was defined as the difference between 24-h systolic ABP at the high-salt versus the low-salt periods. Baseline renin and Nt-proANP were related to salt sensitivity. Results Lowering of salt intake from 150 to 50 mmol/day induced significant blood pressure reductions (mean reduction, 95% confidence interval) in systolic and diastolic 24-h ABP (5.8, 3.4-8.2 and 2.6, 0.91 -4.4 mmHg), daytime ABP (5.5, 2.9-8.1 and 2.3, 0.42-4.1 mmHg) and night-time ABP (6.4, 3.5-9.3 and 3.4, 1.4-5.5 mmHg). Baseline In(renin) correlated inversely with salt sensitivity (r = -0.50, P = 0.001) whereas baseline In(Nt-proANP) correlated directly (r = 0.33, P = 0.04). Conclusion Lowering of salt intake with 100 mmol/day induces clinically relevant ABP reductions. Renin and Nt-proANP, measured with individuals on their habitual diet, could be useful biomarkers to identify individuals with the greatest blood pressure-lowering benefit from reduced salt intake. (Less)

Please use this url to cite or link to this publication: https://lup.lub.lu.se/record/165880

author

Melander, Olle ^LU

; Wowern, Fredrik ^LU ; Frandsen, Erik ; Burri, Philippe ^LU ; Willsteen, Gunilla ; Aurell, Mattias and Hulthén, Lennart ^LU

organization

publishing date

2007

type

Contribution to journal

publication status

published

subject

Cardiac and Cardiovascular Systems

keywords

salt, salt intake, renin, blood pressure, atrial natriuretic peptide, sensitivity

in

Journal of Hypertension

volume

25

issue

3

pages

619 - 627

publisher

Lippincott Williams & Wilkins

external identifiers

wos:000244388800020
scopus:33846781416

ISSN

1473-5598

DOI

10.1097/HJH.0b013e328013cd50

language

English

LU publication?

yes

additional info

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pediatrics/Urology/Gynecology/Endocrinology (013240400), Hypertension and Cardiovascular Disease (013242540), Diabetes and Endocrinology (013241530)

id

7e89e1f2-2103-4a24-a7cb-a825132427cb (old id 165880)

alternative location

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17278979&dopt=Abstract

date added to LUP

2016-04-01 16:39:09

date last changed

2024-03-13 10:44:28

@article{7e89e1f2-2103-4a24-a7cb-a825132427cb,
  abstract     = {{Objective The effect of salt restriction on blood pressure is under intense debate. We tested the effect of 100 mmol salt reduction on ambulatory blood pressure (ABP) in 46 Swedish individuals, 39 of whom completed the study, using a double-blind, placebo-controlled, crossover design. Furthermore, we tested whether the basal plasma concentration of renin or N-terminal atrial natriuretic peptide (Nt-proANP) predict the degree of salt sensitivity. Methods Participants received all meals and drinks with a total daily NaCl content of 50 mmol during 8 weeks. In addition, NaCl capsules (1100 mmol/day) and corresponding placebo capsules were administered for 4 weeks each in random order. ABP after high-salt intake (1150 mmol/day) was compared with ABP after low-salt intake (50 mmol/ day). Salt sensitivity was defined as the difference between 24-h systolic ABP at the high-salt versus the low-salt periods. Baseline renin and Nt-proANP were related to salt sensitivity. Results Lowering of salt intake from 150 to 50 mmol/day induced significant blood pressure reductions (mean reduction, 95% confidence interval) in systolic and diastolic 24-h ABP (5.8, 3.4-8.2 and 2.6, 0.91 -4.4 mmHg), daytime ABP (5.5, 2.9-8.1 and 2.3, 0.42-4.1 mmHg) and night-time ABP (6.4, 3.5-9.3 and 3.4, 1.4-5.5 mmHg). Baseline In(renin) correlated inversely with salt sensitivity (r = -0.50, P = 0.001) whereas baseline In(Nt-proANP) correlated directly (r = 0.33, P = 0.04). Conclusion Lowering of salt intake with 100 mmol/day induces clinically relevant ABP reductions. Renin and Nt-proANP, measured with individuals on their habitual diet, could be useful biomarkers to identify individuals with the greatest blood pressure-lowering benefit from reduced salt intake.}},
  author       = {{Melander, Olle and Wowern, Fredrik and Frandsen, Erik and Burri, Philippe and Willsteen, Gunilla and Aurell, Mattias and Hulthén, Lennart}},
  issn         = {{1473-5598}},
  keywords     = {{salt; salt intake; renin; blood pressure; atrial natriuretic peptide; sensitivity}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{619--627}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Journal of Hypertension}},
  title        = {{Moderate salt restriction effectively lowers blood pressure and degree of salt sensitivity is related to baseline concentration of renin and N-terminal atrial natriuretic peptide in plasma.}},
  url          = {{http://dx.doi.org/10.1097/HJH.0b013e328013cd50}},
  doi          = {{10.1097/HJH.0b013e328013cd50}},
  volume       = {{25}},
  year         = {{2007}},
}

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Moderate salt restriction effectively lowers blood pressure and degree of salt sensitivity is related to baseline concentration of renin and N-terminal atrial natriuretic peptide in plasma.