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Soluble adhesion molecules and angiotensin-converting enzyme in dementia.

Nielsen, Henrietta LU ; Londos, Elisabet LU ; Minthon, Lennart LU and Janciauskiene, Sabina LU (2007) In Neurobiology of Disease 26. p.27-35
Abstract
We aimed to determine plasma and cerebrospinal fluid (CSF) levels of angiotensin-converting enzyme (ACE) and the soluble forms of intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1) and platelet endothelial cell adhesion molecule-1 (sPECAM-1) as surrogate markers for endothelial cell activation in clinically diagnosed patients with Alzheimer's disease (AD, n=260), dementia with Lewy bodies (DLB, n=39) and non-demented controls (n=34). Plasma sICAM-1 and sPECAM-1 were higher and CSF sVCAM-1 were lower in AD and DLB patients than in controls (p < 0.001). DLB patients had higher CSF sICAM-1, but lower CSF sVCAM-1 (p < 0.001). No difference in ACE levels was found between the dementia groups and... (More)
We aimed to determine plasma and cerebrospinal fluid (CSF) levels of angiotensin-converting enzyme (ACE) and the soluble forms of intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1) and platelet endothelial cell adhesion molecule-1 (sPECAM-1) as surrogate markers for endothelial cell activation in clinically diagnosed patients with Alzheimer's disease (AD, n=260), dementia with Lewy bodies (DLB, n=39) and non-demented controls (n=34). Plasma sICAM-1 and sPECAM-1 were higher and CSF sVCAM-1 were lower in AD and DLB patients than in controls (p < 0.001). DLB patients had higher CSF sICAM-1, but lower CSF sVCAM-1 (p < 0.001). No difference in ACE levels was found between the dementia groups and controls. In controls and AD patients CSF sICAM and sVCAM-1 strongly correlated with each other and with blood barrier permeability whereas in DLB group these correlations were weaker. The observed patterns in adhesion molecules may reflect distinctions in the pathophysiological basis of their generation in dementia patients. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Neurobiology of Disease
volume
26
pages
27 - 35
publisher
Elsevier
external identifiers
  • wos:000245374000003
  • scopus:33947205974
ISSN
0969-9961
DOI
10.1016/j.nbd.2006.11.011
language
English
LU publication?
yes
id
52e04211-cbce-4c5a-9015-3088df65c8a4 (old id 165970)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17270454&dopt=Abstract
date added to LUP
2007-07-26 15:19:00
date last changed
2017-09-17 04:57:55
@article{52e04211-cbce-4c5a-9015-3088df65c8a4,
  abstract     = {We aimed to determine plasma and cerebrospinal fluid (CSF) levels of angiotensin-converting enzyme (ACE) and the soluble forms of intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1) and platelet endothelial cell adhesion molecule-1 (sPECAM-1) as surrogate markers for endothelial cell activation in clinically diagnosed patients with Alzheimer's disease (AD, n=260), dementia with Lewy bodies (DLB, n=39) and non-demented controls (n=34). Plasma sICAM-1 and sPECAM-1 were higher and CSF sVCAM-1 were lower in AD and DLB patients than in controls (p &lt; 0.001). DLB patients had higher CSF sICAM-1, but lower CSF sVCAM-1 (p &lt; 0.001). No difference in ACE levels was found between the dementia groups and controls. In controls and AD patients CSF sICAM and sVCAM-1 strongly correlated with each other and with blood barrier permeability whereas in DLB group these correlations were weaker. The observed patterns in adhesion molecules may reflect distinctions in the pathophysiological basis of their generation in dementia patients.},
  author       = {Nielsen, Henrietta and Londos, Elisabet and Minthon, Lennart and Janciauskiene, Sabina},
  issn         = {0969-9961},
  language     = {eng},
  pages        = {27--35},
  publisher    = {Elsevier},
  series       = {Neurobiology of Disease},
  title        = {Soluble adhesion molecules and angiotensin-converting enzyme in dementia.},
  url          = {http://dx.doi.org/10.1016/j.nbd.2006.11.011},
  volume       = {26},
  year         = {2007},
}