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Use of anti-asthmatic drugs during pregnancy. 1. Maternal characteristics, pregnancy and delivery complications.

Källén, Bengt LU and Otterblad Olausson, Petra (2007) In European Journal of Clinical Pharmacology 63. p.363-373
Abstract
Objective To study, in a large cohort, the association between the use of anti-asthmatic drugs during pregnancy and pregnancy complications. Methods Using the Swedish Medical Birth Register, we identified 24,369 women who reported the use of anti-asthmatic drugs in early pregnancy and 7778 women who were prescribed such drugs later during pregnancy by antenatal care system centres, during the period July 1, 1995 up to and including 2004. We studied maternal characteristics and pregnancy and delivery complications. Comparisons were made with all women having given birth to a child recorded in the register during this period. Results Women using anti-asthmatic drugs were characterized by a young maternal age, low parity, increased rate of... (More)
Objective To study, in a large cohort, the association between the use of anti-asthmatic drugs during pregnancy and pregnancy complications. Methods Using the Swedish Medical Birth Register, we identified 24,369 women who reported the use of anti-asthmatic drugs in early pregnancy and 7778 women who were prescribed such drugs later during pregnancy by antenatal care system centres, during the period July 1, 1995 up to and including 2004. We studied maternal characteristics and pregnancy and delivery complications. Comparisons were made with all women having given birth to a child recorded in the register during this period. Results Women using anti-asthmatic drugs were characterized by a young maternal age, low parity, increased rate of smoking, low education, and high body mass index. An association with subfertility was also observed. Pre-existing diabetes did not occur in excess. A number of pregnancy and delivery complications occurred at an increased rate with the use of anti-asthmatic drugs, notably when three or more such drugs had been used: gestational diabetes [odds ratio (OR) = 1.59], preeclampsia (OR=1.44), haemorrhage at delivery (OR=1.32) and premature rupture of membranes (OR=1.59); no excess of placenta abruption or previa was found. Primary weak contractions occurred more often than expected in women that used anti-asthmatic drugs (OR=1.15), and this was tentatively linked to the use of beta-2 adrenergic agonists. Most of the increased risk for caesarean section (OR=1.79) could be explained by these pregnancy complications. An increased risk for delivery induction (OR=1.74) was found among deliveries that did not start with a caesarean section. Conclusion An increase risk of pregnancy complications occurs with the use of anti-asthmatic drugs by pregnant women, which results in an increased rate of caesarean sections. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
anti-asthmatic drugs, adrenergic beta-2 adrenergic agonist, asthma, delivery, pregnancy complications
in
European Journal of Clinical Pharmacology
volume
63
pages
363 - 373
publisher
Springer
external identifiers
  • wos:000244821400005
  • scopus:33947142396
ISSN
1432-1041
DOI
10.1007/s00228-006-0257-1
language
English
LU publication?
yes
id
9d557621-52fd-448a-85ce-ef9e4d1cec9d (old id 166004)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17265060&dopt=Abstract
date added to LUP
2007-07-23 13:17:12
date last changed
2017-08-13 04:19:28
@article{9d557621-52fd-448a-85ce-ef9e4d1cec9d,
  abstract     = {Objective To study, in a large cohort, the association between the use of anti-asthmatic drugs during pregnancy and pregnancy complications. Methods Using the Swedish Medical Birth Register, we identified 24,369 women who reported the use of anti-asthmatic drugs in early pregnancy and 7778 women who were prescribed such drugs later during pregnancy by antenatal care system centres, during the period July 1, 1995 up to and including 2004. We studied maternal characteristics and pregnancy and delivery complications. Comparisons were made with all women having given birth to a child recorded in the register during this period. Results Women using anti-asthmatic drugs were characterized by a young maternal age, low parity, increased rate of smoking, low education, and high body mass index. An association with subfertility was also observed. Pre-existing diabetes did not occur in excess. A number of pregnancy and delivery complications occurred at an increased rate with the use of anti-asthmatic drugs, notably when three or more such drugs had been used: gestational diabetes [odds ratio (OR) = 1.59], preeclampsia (OR=1.44), haemorrhage at delivery (OR=1.32) and premature rupture of membranes (OR=1.59); no excess of placenta abruption or previa was found. Primary weak contractions occurred more often than expected in women that used anti-asthmatic drugs (OR=1.15), and this was tentatively linked to the use of beta-2 adrenergic agonists. Most of the increased risk for caesarean section (OR=1.79) could be explained by these pregnancy complications. An increased risk for delivery induction (OR=1.74) was found among deliveries that did not start with a caesarean section. Conclusion An increase risk of pregnancy complications occurs with the use of anti-asthmatic drugs by pregnant women, which results in an increased rate of caesarean sections.},
  author       = {Källén, Bengt and Otterblad Olausson, Petra},
  issn         = {1432-1041},
  keyword      = {anti-asthmatic drugs,adrenergic beta-2 adrenergic agonist,asthma,delivery,pregnancy complications},
  language     = {eng},
  pages        = {363--373},
  publisher    = {Springer},
  series       = {European Journal of Clinical Pharmacology},
  title        = {Use of anti-asthmatic drugs during pregnancy. 1. Maternal characteristics, pregnancy and delivery complications.},
  url          = {http://dx.doi.org/10.1007/s00228-006-0257-1},
  volume       = {63},
  year         = {2007},
}