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Use of anti-asthmatic drugs during pregnancy. 2. Infant characteristics excluding congenital malformations.

Källén, Bengt LU and Olausson, Petra (2007) In European Journal of Clinical Pharmacology 63. p.375-381
Abstract
Objective To study the characteristics of the infants born to women who have used anti-asthmatic drugs during pregnancy. Material and methods Various characteristics of infants with mothers who had reported the use of anti-asthmatic drugs in early pregnancy (n=24,750) or had such drugs prescribed later during pregnancy by a maternity health care centre (n=763) were identified from the Swedish Medical Birth Register and compared to those of all infants. Risks estimated with Mantel-Haenszel technique were expressed as odds ratios (OR) with 95% confidence intervals after adjustment for a number of putative confounders. The severity of maternal asthma was assessed on the basis of the number of anti-asthmatic drugs used. Results An increased... (More)
Objective To study the characteristics of the infants born to women who have used anti-asthmatic drugs during pregnancy. Material and methods Various characteristics of infants with mothers who had reported the use of anti-asthmatic drugs in early pregnancy (n=24,750) or had such drugs prescribed later during pregnancy by a maternity health care centre (n=763) were identified from the Swedish Medical Birth Register and compared to those of all infants. Risks estimated with Mantel-Haenszel technique were expressed as odds ratios (OR) with 95% confidence intervals after adjustment for a number of putative confounders. The severity of maternal asthma was assessed on the basis of the number of anti-asthmatic drugs used. Results An increased risk for preterm birth, low birth weight and small for gestational age was found, which increased with the number of anti-asthmatic drugs used by the mother during pregnancy (OR=1.46, 1.67, and 1.70, respectively, when three or more drugs had been used). An increased risk for large for gestational age could be explained by the effect of gestational diabetes and high body mass index. An increased risk for neonatal icterus was mainly an effect of preterm birth, while an increased risk for respiratory problems and/or low Apgar score (OR=1.43) was only slightly reduced in full-term infants. An increased risk for hyperglycaemia (OR=1.62) was not explained by confounding from maternal diabetes. No risk increase was found for neonatal convulsions or cerebral haemorrhage. Mortality was increased only among infants whose mother had used three or more anti-asthmatic drugs (OR=1.52). Conclusion Infants whose mothers had asthma had a number of manifestations of poor outcome which appeared to be linked with the severity of the asthma. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
preterm birth, asthma, infant mortality, neonatal disease, foetal growth retardation
in
European Journal of Clinical Pharmacology
volume
63
pages
375 - 381
publisher
Springer
external identifiers
  • wos:000244821400006
  • scopus:33947096880
ISSN
1432-1041
DOI
10.1007/s00228-006-0258-0
language
English
LU publication?
yes
id
cffe73b7-6a8a-4b0a-a4cc-773ffdb63ca4 (old id 166008)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17265059&dopt=Abstract
date added to LUP
2007-07-23 13:19:16
date last changed
2017-02-22 10:46:49
@article{cffe73b7-6a8a-4b0a-a4cc-773ffdb63ca4,
  abstract     = {Objective To study the characteristics of the infants born to women who have used anti-asthmatic drugs during pregnancy. Material and methods Various characteristics of infants with mothers who had reported the use of anti-asthmatic drugs in early pregnancy (n=24,750) or had such drugs prescribed later during pregnancy by a maternity health care centre (n=763) were identified from the Swedish Medical Birth Register and compared to those of all infants. Risks estimated with Mantel-Haenszel technique were expressed as odds ratios (OR) with 95% confidence intervals after adjustment for a number of putative confounders. The severity of maternal asthma was assessed on the basis of the number of anti-asthmatic drugs used. Results An increased risk for preterm birth, low birth weight and small for gestational age was found, which increased with the number of anti-asthmatic drugs used by the mother during pregnancy (OR=1.46, 1.67, and 1.70, respectively, when three or more drugs had been used). An increased risk for large for gestational age could be explained by the effect of gestational diabetes and high body mass index. An increased risk for neonatal icterus was mainly an effect of preterm birth, while an increased risk for respiratory problems and/or low Apgar score (OR=1.43) was only slightly reduced in full-term infants. An increased risk for hyperglycaemia (OR=1.62) was not explained by confounding from maternal diabetes. No risk increase was found for neonatal convulsions or cerebral haemorrhage. Mortality was increased only among infants whose mother had used three or more anti-asthmatic drugs (OR=1.52). Conclusion Infants whose mothers had asthma had a number of manifestations of poor outcome which appeared to be linked with the severity of the asthma.},
  author       = {Källén, Bengt and Olausson, Petra},
  issn         = {1432-1041},
  keyword      = {preterm birth,asthma,infant mortality,neonatal disease,foetal growth retardation},
  language     = {eng},
  pages        = {375--381},
  publisher    = {Springer},
  series       = {European Journal of Clinical Pharmacology},
  title        = {Use of anti-asthmatic drugs during pregnancy. 2. Infant characteristics excluding congenital malformations.},
  url          = {http://dx.doi.org/10.1007/s00228-006-0258-0},
  volume       = {63},
  year         = {2007},
}