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Dose dependence of mass and microcalcification detection in digital mammography: free response human observer studies.

Ruschin, Mark LU ; Timberg, Pontus LU ; Bath, Magnus; Hemdal, Bengt LU ; Svahn, Tony LU ; Saunders, Rob S; Samei, Ehsan; Andersson, Ingvar LU ; Mattsson, Sören LU and Chakrabort, Dev P, et al. (2007) In Medical Physics 34(2). p.400-407
Abstract
The purpose of this study was to evaluate the effect of dose reduction in digital mammography on the detection of two lesion types-malignant masses and clusters of microcalcifications. Two free-response observer studies were performed-one for each lesion type. Ninety screening images were retrospectively selected; each image was originally acquired under automatic exposure conditions, corresponding to an average glandular dose of 1.3 mGy for a standard breast (50 mm compressed breast thickness with 50% glandularity). For each study, one to three simulated lesions were added to each of 40 images (abnormals) while 50 were kept without lesions (normals). Two levels of simulated system noise were added to the images yielding two new image... (More)
The purpose of this study was to evaluate the effect of dose reduction in digital mammography on the detection of two lesion types-malignant masses and clusters of microcalcifications. Two free-response observer studies were performed-one for each lesion type. Ninety screening images were retrospectively selected; each image was originally acquired under automatic exposure conditions, corresponding to an average glandular dose of 1.3 mGy for a standard breast (50 mm compressed breast thickness with 50% glandularity). For each study, one to three simulated lesions were added to each of 40 images (abnormals) while 50 were kept without lesions (normals). Two levels of simulated system noise were added to the images yielding two new image sets, corresponding to simulated dose levels of 50% and 30% of the original images (100%). The manufacturer's standard display processing was subsequently applied to all images. Four radiologists experienced in mammography evaluated the images by searching for lesions and marking and assigning confidence levels to suspicious regions. The search data were analyzed using jackknife free-response (JAFROC) methodology. For the detection of masses, the mean figure-of-merit (FOM) averaged over all readers was 0.74, 0.71, and 0.68 corresponding to dose levels of 100%, 50%, and 30%, respectively. These values were not statistically different from each other (F = 1.67, p = 0.19) but showed a decreasing trend. In contrast, in the microcalcification study the mean FOM was 0.93, 0.67, and 0.38 for the same dose levels and these values were all significantly different from each other (F = 109.84, p < 0.000 1). The results indicate that lowering the present dose level by a factor of two compromised the detection of microcalcifications but had a weaker effect on mass detection. (Less)
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Contribution to journal
publication status
published
subject
keywords
observer performance, free response, dose reduction, Digital mammography
in
Medical Physics
volume
34
issue
2
pages
400 - 407
publisher
American Association of Physicists in Medicine
external identifiers
  • wos:000244424200004
  • scopus:33846592291
ISSN
0094-2405
DOI
10.1118/1.2405324
language
English
LU publication?
yes
id
0347e883-c8d0-4dbf-a5e9-d66973ea49a7 (old id 166203)
alternative location
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17388156
date added to LUP
2007-07-30 14:46:45
date last changed
2017-02-26 04:07:21
@article{0347e883-c8d0-4dbf-a5e9-d66973ea49a7,
  abstract     = {The purpose of this study was to evaluate the effect of dose reduction in digital mammography on the detection of two lesion types-malignant masses and clusters of microcalcifications. Two free-response observer studies were performed-one for each lesion type. Ninety screening images were retrospectively selected; each image was originally acquired under automatic exposure conditions, corresponding to an average glandular dose of 1.3 mGy for a standard breast (50 mm compressed breast thickness with 50% glandularity). For each study, one to three simulated lesions were added to each of 40 images (abnormals) while 50 were kept without lesions (normals). Two levels of simulated system noise were added to the images yielding two new image sets, corresponding to simulated dose levels of 50% and 30% of the original images (100%). The manufacturer's standard display processing was subsequently applied to all images. Four radiologists experienced in mammography evaluated the images by searching for lesions and marking and assigning confidence levels to suspicious regions. The search data were analyzed using jackknife free-response (JAFROC) methodology. For the detection of masses, the mean figure-of-merit (FOM) averaged over all readers was 0.74, 0.71, and 0.68 corresponding to dose levels of 100%, 50%, and 30%, respectively. These values were not statistically different from each other (F = 1.67, p = 0.19) but showed a decreasing trend. In contrast, in the microcalcification study the mean FOM was 0.93, 0.67, and 0.38 for the same dose levels and these values were all significantly different from each other (F = 109.84, p &lt; 0.000 1). The results indicate that lowering the present dose level by a factor of two compromised the detection of microcalcifications but had a weaker effect on mass detection.},
  author       = {Ruschin, Mark and Timberg, Pontus and Bath, Magnus and Hemdal, Bengt and Svahn, Tony and Saunders, Rob S and Samei, Ehsan and Andersson, Ingvar and Mattsson, Sören and Chakrabort, Dev P and Tingberg, Anders},
  issn         = {0094-2405},
  keyword      = {observer performance,free response,dose reduction,Digital mammography},
  language     = {eng},
  number       = {2},
  pages        = {400--407},
  publisher    = {American Association of Physicists in Medicine},
  series       = {Medical Physics},
  title        = {Dose dependence of mass and microcalcification detection in digital mammography: free response human observer studies.},
  url          = {http://dx.doi.org/10.1118/1.2405324},
  volume       = {34},
  year         = {2007},
}