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Increased fetal blood pressure response to maternal norepinephrine after pharmacological inhibition f norepinephrine uptake in pregnant sheep.

Hansson, Stefan LU ; Bottalico, B; Amer-Wåhlin, Isis LU ; Marsal, Karel LU and Ley, David LU (2007) In Acta Pædiatrica 96(5). p.650-654
Abstract
Objective: Norepinephrine (NE) is elevated in pregnancies complicated by preeclampsia (PE). Specific uptake of NE by the NE transporter (NET) plays a central role as regulator of NE levels. Expression of NET is reduced in placentas from PE pregnancies. To study adverse fetal effects of reduced NET expression on the placental buffering capacity, the NET was pharmacologically blocked by a specific uptake inhibitor reboxetine. Study Design: We evaluated the effect of NE uptake inhibition on maternal and fetal arterial blood pressure responses to increasing maternal doses of NE in 10 chronically prepared fetal sheep. Arterial blood pressure was monitored continuously during increasing doses of iv NE. Results: NET inhibition increased both... (More)
Objective: Norepinephrine (NE) is elevated in pregnancies complicated by preeclampsia (PE). Specific uptake of NE by the NE transporter (NET) plays a central role as regulator of NE levels. Expression of NET is reduced in placentas from PE pregnancies. To study adverse fetal effects of reduced NET expression on the placental buffering capacity, the NET was pharmacologically blocked by a specific uptake inhibitor reboxetine. Study Design: We evaluated the effect of NE uptake inhibition on maternal and fetal arterial blood pressure responses to increasing maternal doses of NE in 10 chronically prepared fetal sheep. Arterial blood pressure was monitored continuously during increasing doses of iv NE. Results: NET inhibition increased both fetal and maternal mean arterial blood pressure (p < 0.001, respectively). Conclusion: Reuptake by NET appears to be a mechanism protecting the fetus from NE. A reduced uptake capacity in preeclamptic pregnancies due to reduced NE uptake may lead to increased fetal arterial blood pressure. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
reboxetine, monoamine transporter, blood flow, placenta, hypertension
in
Acta Pædiatrica
volume
96
issue
5
pages
650 - 654
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • wos:000245985500011
  • scopus:34247520554
ISSN
1651-2227
DOI
10.1111/j.1651-2227.2007.00262.x
language
English
LU publication?
yes
id
d3836ecf-6b41-464d-a643-6bfe895be698 (old id 166261)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17381469&dopt=Abstract
date added to LUP
2007-07-23 10:49:13
date last changed
2017-01-08 05:19:33
@article{d3836ecf-6b41-464d-a643-6bfe895be698,
  abstract     = {Objective: Norepinephrine (NE) is elevated in pregnancies complicated by preeclampsia (PE). Specific uptake of NE by the NE transporter (NET) plays a central role as regulator of NE levels. Expression of NET is reduced in placentas from PE pregnancies. To study adverse fetal effects of reduced NET expression on the placental buffering capacity, the NET was pharmacologically blocked by a specific uptake inhibitor reboxetine. Study Design: We evaluated the effect of NE uptake inhibition on maternal and fetal arterial blood pressure responses to increasing maternal doses of NE in 10 chronically prepared fetal sheep. Arterial blood pressure was monitored continuously during increasing doses of iv NE. Results: NET inhibition increased both fetal and maternal mean arterial blood pressure (p &lt; 0.001, respectively). Conclusion: Reuptake by NET appears to be a mechanism protecting the fetus from NE. A reduced uptake capacity in preeclamptic pregnancies due to reduced NE uptake may lead to increased fetal arterial blood pressure.},
  author       = {Hansson, Stefan and Bottalico, B and Amer-Wåhlin, Isis and Marsal, Karel and Ley, David},
  issn         = {1651-2227},
  keyword      = {reboxetine,monoamine transporter,blood flow,placenta,hypertension},
  language     = {eng},
  number       = {5},
  pages        = {650--654},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Acta Pædiatrica},
  title        = {Increased fetal blood pressure response to maternal norepinephrine after pharmacological inhibition f norepinephrine uptake in pregnant sheep.},
  url          = {http://dx.doi.org/10.1111/j.1651-2227.2007.00262.x},
  volume       = {96},
  year         = {2007},
}