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Prediction of Alzheimer's Disease Using the CSF Abeta42/Abeta40 Ratio in Patients with Mild Cognitive Impairment.

Hansson, Oskar LU ; Zetterberg, Henrik; Buchhave, Peder; Andreasson, Ulf; Londos, Elisabet LU ; Minthon, Lennart LU and Blennow, Kaj (2007) In Dementia and Geriatric Cognitive Disorders 23(5). p.316-320
Abstract
Evidence supports an important role for beta-amyloid (A beta) in the pathogenesis of Alzheimer's disease ( AD). Here, we investigate baseline levels of the 40- and 42-amino-acid-long A beta peptides (A beta 40 and A beta 42) in cerebrospinal fluid (CSF) from a cohort of patients with mild cognitive impairment (MCI, n = 137) in relation to the final diagnosis after 4 - 6 years of follow-up time. CSF A beta 42 concentration at baseline and the A beta 42/A beta 40 ratio were significantly decreased in the MCI patients who developed AD as compared to cognitively stable MCI patients and MCI patients who developed other forms of dementia ( p < 0.001). The baseline levels of A beta 40 were similar in all MCI groups but correlated with change... (More)
Evidence supports an important role for beta-amyloid (A beta) in the pathogenesis of Alzheimer's disease ( AD). Here, we investigate baseline levels of the 40- and 42-amino-acid-long A beta peptides (A beta 40 and A beta 42) in cerebrospinal fluid (CSF) from a cohort of patients with mild cognitive impairment (MCI, n = 137) in relation to the final diagnosis after 4 - 6 years of follow-up time. CSF A beta 42 concentration at baseline and the A beta 42/A beta 40 ratio were significantly decreased in the MCI patients who developed AD as compared to cognitively stable MCI patients and MCI patients who developed other forms of dementia ( p < 0.001). The baseline levels of A beta 40 were similar in all MCI groups but correlated with change in Mini Mental State Examination scores in converters to AD. The A beta 42/A beta 40 ratio was superior to A beta 42 concentration with regard to identifying incipient AD in MCI ( p < 0.05). In conclusion, the data provide further support for the view that amyloid precursor protein metabolism is disturbed in early sporadic AD and points to the usefulness of the A beta 42/ A beta 40 ratio as a predictive biomarker for AD. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Dementia and Geriatric Cognitive Disorders
volume
23
issue
5
pages
316 - 320
publisher
Karger
external identifiers
  • wos:000245138100006
  • scopus:34247384609
ISSN
1420-8008
DOI
10.1159/000100926
language
English
LU publication?
yes
id
8cdaf9f6-24ae-48d7-b6e9-4b146b2eb9a7 (old id 166318)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17374949&dopt=Abstract
date added to LUP
2007-07-23 13:34:58
date last changed
2017-10-01 03:47:38
@article{8cdaf9f6-24ae-48d7-b6e9-4b146b2eb9a7,
  abstract     = {Evidence supports an important role for beta-amyloid (A beta) in the pathogenesis of Alzheimer's disease ( AD). Here, we investigate baseline levels of the 40- and 42-amino-acid-long A beta peptides (A beta 40 and A beta 42) in cerebrospinal fluid (CSF) from a cohort of patients with mild cognitive impairment (MCI, n = 137) in relation to the final diagnosis after 4 - 6 years of follow-up time. CSF A beta 42 concentration at baseline and the A beta 42/A beta 40 ratio were significantly decreased in the MCI patients who developed AD as compared to cognitively stable MCI patients and MCI patients who developed other forms of dementia ( p &lt; 0.001). The baseline levels of A beta 40 were similar in all MCI groups but correlated with change in Mini Mental State Examination scores in converters to AD. The A beta 42/A beta 40 ratio was superior to A beta 42 concentration with regard to identifying incipient AD in MCI ( p &lt; 0.05). In conclusion, the data provide further support for the view that amyloid precursor protein metabolism is disturbed in early sporadic AD and points to the usefulness of the A beta 42/ A beta 40 ratio as a predictive biomarker for AD.},
  author       = {Hansson, Oskar and Zetterberg, Henrik and Buchhave, Peder and Andreasson, Ulf and Londos, Elisabet and Minthon, Lennart and Blennow, Kaj},
  issn         = {1420-8008},
  language     = {eng},
  number       = {5},
  pages        = {316--320},
  publisher    = {Karger},
  series       = {Dementia and Geriatric Cognitive Disorders},
  title        = {Prediction of Alzheimer's Disease Using the CSF Abeta42/Abeta40 Ratio in Patients with Mild Cognitive Impairment.},
  url          = {http://dx.doi.org/10.1159/000100926},
  volume       = {23},
  year         = {2007},
}