Prediction of Alzheimer's Disease Using the CSF Abeta42/Abeta40 Ratio in Patients with Mild Cognitive Impairment.
(2007) In Dementia and Geriatric Cognitive Disorders 23(5). p.316-320- Abstract
- Evidence supports an important role for beta-amyloid (A beta) in the pathogenesis of Alzheimer's disease ( AD). Here, we investigate baseline levels of the 40- and 42-amino-acid-long A beta peptides (A beta 40 and A beta 42) in cerebrospinal fluid (CSF) from a cohort of patients with mild cognitive impairment (MCI, n = 137) in relation to the final diagnosis after 4 - 6 years of follow-up time. CSF A beta 42 concentration at baseline and the A beta 42/A beta 40 ratio were significantly decreased in the MCI patients who developed AD as compared to cognitively stable MCI patients and MCI patients who developed other forms of dementia ( p < 0.001). The baseline levels of A beta 40 were similar in all MCI groups but correlated with change... (More)
- Evidence supports an important role for beta-amyloid (A beta) in the pathogenesis of Alzheimer's disease ( AD). Here, we investigate baseline levels of the 40- and 42-amino-acid-long A beta peptides (A beta 40 and A beta 42) in cerebrospinal fluid (CSF) from a cohort of patients with mild cognitive impairment (MCI, n = 137) in relation to the final diagnosis after 4 - 6 years of follow-up time. CSF A beta 42 concentration at baseline and the A beta 42/A beta 40 ratio were significantly decreased in the MCI patients who developed AD as compared to cognitively stable MCI patients and MCI patients who developed other forms of dementia ( p < 0.001). The baseline levels of A beta 40 were similar in all MCI groups but correlated with change in Mini Mental State Examination scores in converters to AD. The A beta 42/A beta 40 ratio was superior to A beta 42 concentration with regard to identifying incipient AD in MCI ( p < 0.05). In conclusion, the data provide further support for the view that amyloid precursor protein metabolism is disturbed in early sporadic AD and points to the usefulness of the A beta 42/ A beta 40 ratio as a predictive biomarker for AD. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/166318
- author
- Hansson, Oskar LU ; Zetterberg, Henrik ; Buchhave, Peder ; Andreasson, Ulf ; Londos, Elisabet LU ; Minthon, Lennart LU and Blennow, Kaj
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Dementia and Geriatric Cognitive Disorders
- volume
- 23
- issue
- 5
- pages
- 316 - 320
- publisher
- Karger
- external identifiers
-
- wos:000245138100006
- scopus:34247384609
- ISSN
- 1420-8008
- DOI
- 10.1159/000100926
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Clinical Memory Research Unit (013242610), Psychiatry/Primary Care/Public Health (013240500)
- id
- 8cdaf9f6-24ae-48d7-b6e9-4b146b2eb9a7 (old id 166318)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17374949&dopt=Abstract
- date added to LUP
- 2016-04-01 12:06:24
- date last changed
- 2022-05-14 17:38:55
@article{8cdaf9f6-24ae-48d7-b6e9-4b146b2eb9a7, abstract = {{Evidence supports an important role for beta-amyloid (A beta) in the pathogenesis of Alzheimer's disease ( AD). Here, we investigate baseline levels of the 40- and 42-amino-acid-long A beta peptides (A beta 40 and A beta 42) in cerebrospinal fluid (CSF) from a cohort of patients with mild cognitive impairment (MCI, n = 137) in relation to the final diagnosis after 4 - 6 years of follow-up time. CSF A beta 42 concentration at baseline and the A beta 42/A beta 40 ratio were significantly decreased in the MCI patients who developed AD as compared to cognitively stable MCI patients and MCI patients who developed other forms of dementia ( p < 0.001). The baseline levels of A beta 40 were similar in all MCI groups but correlated with change in Mini Mental State Examination scores in converters to AD. The A beta 42/A beta 40 ratio was superior to A beta 42 concentration with regard to identifying incipient AD in MCI ( p < 0.05). In conclusion, the data provide further support for the view that amyloid precursor protein metabolism is disturbed in early sporadic AD and points to the usefulness of the A beta 42/ A beta 40 ratio as a predictive biomarker for AD.}}, author = {{Hansson, Oskar and Zetterberg, Henrik and Buchhave, Peder and Andreasson, Ulf and Londos, Elisabet and Minthon, Lennart and Blennow, Kaj}}, issn = {{1420-8008}}, language = {{eng}}, number = {{5}}, pages = {{316--320}}, publisher = {{Karger}}, series = {{Dementia and Geriatric Cognitive Disorders}}, title = {{Prediction of Alzheimer's Disease Using the CSF Abeta42/Abeta40 Ratio in Patients with Mild Cognitive Impairment.}}, url = {{http://dx.doi.org/10.1159/000100926}}, doi = {{10.1159/000100926}}, volume = {{23}}, year = {{2007}}, }