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Ornithine decarboxylase and S-adenosylmethionine decarboxylase in trypanosomatids.

Persson, Lo LU (2007) In Biochemical Society Transactions 35(Pt 2). p.314-317
Abstract
The production of polyamines has been shown to be an effective target for a drug against the West African form of sleeping sickness caused by Trypanosoma brucei gambiense. T. brucei belongs to the group of protozoan parasites classed as trypanosomatids. Parasitic species of this group are the causative agents of various tropical diseases besides African sleeping sickness, e.g. Chagas' disease (Trypanosoma cruzi), cutaneous (lesihmania spp.) and visceral ((eishmania donovani) leishmaniasis. The metabolism of polyamines in the parasites is a potential target for the development of new drugs for treatment of these diseases. The key steps in polyamine synthesis are catalysed by ODC (ornithine decarboxylase) and AdoMetDC (S-adenosylmethionine... (More)
The production of polyamines has been shown to be an effective target for a drug against the West African form of sleeping sickness caused by Trypanosoma brucei gambiense. T. brucei belongs to the group of protozoan parasites classed as trypanosomatids. Parasitic species of this group are the causative agents of various tropical diseases besides African sleeping sickness, e.g. Chagas' disease (Trypanosoma cruzi), cutaneous (lesihmania spp.) and visceral ((eishmania donovani) leishmaniasis. The metabolism of polyamines in the parasites is a potential target for the development of new drugs for treatment of these diseases. The key steps in polyamine synthesis are catalysed by ODC (ornithine decarboxylase) and AdoMetDC (S-adenosylmethionine decarboxylase). In the present paper, some of the available information on ODC and AdoMetDC in trypanosomatids will be described and discussed. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
drug target, decarboxylase, ornithine decarboxylase (ODC), polyamine, protozoan parasite, S-adenosylmethionine
in
Biochemical Society Transactions
volume
35
issue
Pt 2
pages
314 - 317
publisher
Biochemical Society
external identifiers
  • wos:000245705800040
  • scopus:34247139206
ISSN
0300-5127
language
English
LU publication?
yes
id
27e24d7d-f28a-46fd-91f1-b973bfb4cc2a (old id 166367)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17371268&dopt=Abstract
date added to LUP
2007-07-18 16:03:37
date last changed
2017-07-02 03:39:16
@article{27e24d7d-f28a-46fd-91f1-b973bfb4cc2a,
  abstract     = {The production of polyamines has been shown to be an effective target for a drug against the West African form of sleeping sickness caused by Trypanosoma brucei gambiense. T. brucei belongs to the group of protozoan parasites classed as trypanosomatids. Parasitic species of this group are the causative agents of various tropical diseases besides African sleeping sickness, e.g. Chagas' disease (Trypanosoma cruzi), cutaneous (lesihmania spp.) and visceral ((eishmania donovani) leishmaniasis. The metabolism of polyamines in the parasites is a potential target for the development of new drugs for treatment of these diseases. The key steps in polyamine synthesis are catalysed by ODC (ornithine decarboxylase) and AdoMetDC (S-adenosylmethionine decarboxylase). In the present paper, some of the available information on ODC and AdoMetDC in trypanosomatids will be described and discussed.},
  author       = {Persson, Lo},
  issn         = {0300-5127},
  keyword      = {drug target,decarboxylase,ornithine decarboxylase (ODC),polyamine,protozoan parasite,S-adenosylmethionine},
  language     = {eng},
  number       = {Pt 2},
  pages        = {314--317},
  publisher    = {Biochemical Society},
  series       = {Biochemical Society Transactions},
  title        = {Ornithine decarboxylase and S-adenosylmethionine decarboxylase in trypanosomatids.},
  volume       = {35},
  year         = {2007},
}