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Peak CKMB and cTnT accurately estimates myocardial infarct size after reperfusion.

Hedström, Erik LU ; Åström-Olsson, Karin LU ; Öhlin, Hans LU ; Frogner, Fredrik LU ; Carlsson, Marcus LU ; Billgren, Therese; Jovinge, Stefan; Cain, Peter LU ; Wagner, Galen S and Arheden, Håkan LU (2007) In Scandinavian Cardiovascular Journal 41(1). p.44-50
Abstract
Objectives. To find the time-to-peak for creatine kinase MBmass (CKMB) and cardiac troponin T (cTnT) after acute reperfusion, to compare peak and cumulative values to estimate infarct size (IS), and to evaluate clinical routine sampling for assessment of IS. Design. Acute primary percutaneous coronary intervention (PCI) was performed in 38 patients with first-time myocardial infarction. In 21 patients, CKMB and cTnT were acquired before PCI and at 1.5, 3, 6, 12, 18, 24, and 48 hours thereafter. In 17 patients, clinical routine samples were acquired at arrival, and at 10 and 20 h. IS was assessed by delayed contrast-enhanced MRI (DE- MRI). Results. Time-to-peak was 7.6 +/- 3.6 h for CKMB and 8.1 +/- 3.4 h for cTnT. Peak values correlated... (More)
Objectives. To find the time-to-peak for creatine kinase MBmass (CKMB) and cardiac troponin T (cTnT) after acute reperfusion, to compare peak and cumulative values to estimate infarct size (IS), and to evaluate clinical routine sampling for assessment of IS. Design. Acute primary percutaneous coronary intervention (PCI) was performed in 38 patients with first-time myocardial infarction. In 21 patients, CKMB and cTnT were acquired before PCI and at 1.5, 3, 6, 12, 18, 24, and 48 hours thereafter. In 17 patients, clinical routine samples were acquired at arrival, and at 10 and 20 h. IS was assessed by delayed contrast-enhanced MRI (DE- MRI). Results. Time-to-peak was 7.6 +/- 3.6 h for CKMB and 8.1 +/- 3.4 h for cTnT. Peak values correlated strongly to cumulative values (r(s) = 0.97-0.98) as well as to DE-MRI (r(s) = 0.8 - 0.82). Clinical routine sampling showed lower r(s) values (0.47 - 0.60). Conclusions. Peak values are likely captured if CKMB and cTnT are acquired at 3, 6, and 12 h after acute PCI. These peak values can be used to estimate myocardial infarct size after acute PCI. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Cardiovascular Journal
volume
41
issue
1
pages
44 - 50
publisher
Taylor & Francis
external identifiers
  • wos:000244243200009
  • scopus:33847129244
ISSN
1651-2006
DOI
10.1080/14017430601071849
language
English
LU publication?
yes
id
fc28afaa-92ef-4c8f-bbf5-785f43188272 (old id 166461)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17365977&dopt=Abstract
date added to LUP
2007-07-11 10:45:34
date last changed
2017-01-15 04:06:13
@article{fc28afaa-92ef-4c8f-bbf5-785f43188272,
  abstract     = {Objectives. To find the time-to-peak for creatine kinase MBmass (CKMB) and cardiac troponin T (cTnT) after acute reperfusion, to compare peak and cumulative values to estimate infarct size (IS), and to evaluate clinical routine sampling for assessment of IS. Design. Acute primary percutaneous coronary intervention (PCI) was performed in 38 patients with first-time myocardial infarction. In 21 patients, CKMB and cTnT were acquired before PCI and at 1.5, 3, 6, 12, 18, 24, and 48 hours thereafter. In 17 patients, clinical routine samples were acquired at arrival, and at 10 and 20 h. IS was assessed by delayed contrast-enhanced MRI (DE- MRI). Results. Time-to-peak was 7.6 +/- 3.6 h for CKMB and 8.1 +/- 3.4 h for cTnT. Peak values correlated strongly to cumulative values (r(s) = 0.97-0.98) as well as to DE-MRI (r(s) = 0.8 - 0.82). Clinical routine sampling showed lower r(s) values (0.47 - 0.60). Conclusions. Peak values are likely captured if CKMB and cTnT are acquired at 3, 6, and 12 h after acute PCI. These peak values can be used to estimate myocardial infarct size after acute PCI.},
  author       = {Hedström, Erik and Åström-Olsson, Karin and Öhlin, Hans and Frogner, Fredrik and Carlsson, Marcus and Billgren, Therese and Jovinge, Stefan and Cain, Peter and Wagner, Galen S and Arheden, Håkan},
  issn         = {1651-2006},
  language     = {eng},
  number       = {1},
  pages        = {44--50},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Cardiovascular Journal},
  title        = {Peak CKMB and cTnT accurately estimates myocardial infarct size after reperfusion.},
  url          = {http://dx.doi.org/10.1080/14017430601071849},
  volume       = {41},
  year         = {2007},
}