Peak CKMB and cTnT accurately estimates myocardial infarct size after reperfusion.
Hedström, Erik LU
; Åström-Olsson, Karin
LU
; Öhlin, Hans
LU
; Frogner, Fredrik
LU
; Carlsson, Marcus
LU
; Billgren, Therese
; Jovinge, Stefan
; Cain, Peter
LU
; Wagner, Galen S
and Arheden, Håkan
LU
(2007)
In Scandinavian Cardiovascular Journal
41(1).
p.44-50
- Abstract
- Objectives. To find the time-to-peak for creatine kinase MBmass (CKMB) and cardiac troponin T (cTnT) after acute reperfusion, to compare peak and cumulative values to estimate infarct size (IS), and to evaluate clinical routine sampling for assessment of IS. Design. Acute primary percutaneous coronary intervention (PCI) was performed in 38 patients with first-time myocardial infarction. In 21 patients, CKMB and cTnT were acquired before PCI and at 1.5, 3, 6, 12, 18, 24, and 48 hours thereafter. In 17 patients, clinical routine samples were acquired at arrival, and at 10 and 20 h. IS was assessed by delayed contrast-enhanced MRI (DE- MRI). Results. Time-to-peak was 7.6 +/- 3.6 h for CKMB and 8.1 +/- 3.4 h for cTnT. Peak values correlated... (More)
- Objectives. To find the time-to-peak for creatine kinase MBmass (CKMB) and cardiac troponin T (cTnT) after acute reperfusion, to compare peak and cumulative values to estimate infarct size (IS), and to evaluate clinical routine sampling for assessment of IS. Design. Acute primary percutaneous coronary intervention (PCI) was performed in 38 patients with first-time myocardial infarction. In 21 patients, CKMB and cTnT were acquired before PCI and at 1.5, 3, 6, 12, 18, 24, and 48 hours thereafter. In 17 patients, clinical routine samples were acquired at arrival, and at 10 and 20 h. IS was assessed by delayed contrast-enhanced MRI (DE- MRI). Results. Time-to-peak was 7.6 +/- 3.6 h for CKMB and 8.1 +/- 3.4 h for cTnT. Peak values correlated strongly to cumulative values (r(s) = 0.97-0.98) as well as to DE-MRI (r(s) = 0.8 - 0.82). Clinical routine sampling showed lower r(s) values (0.47 - 0.60). Conclusions. Peak values are likely captured if CKMB and cTnT are acquired at 3, 6, and 12 h after acute PCI. These peak values can be used to estimate myocardial infarct size after acute PCI. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/166461
- author
- Hedström, Erik
LU
; Åström-Olsson, Karin
LU
; Öhlin, Hans
LU
; Frogner, Fredrik
LU
; Carlsson, Marcus
LU
; Billgren, Therese
; Jovinge, Stefan
; Cain, Peter
LU
; Wagner, Galen S
and Arheden, Håkan
LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scandinavian Cardiovascular Journal
- volume
- 41
- issue
- 1
- pages
- 44 - 50
- publisher
- Taylor & Francis
- external identifiers
-
- wos:000244243200009
- scopus:33847129244
- ISSN
- 1651-2006
- DOI
- 10.1080/14017430601071849
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Section I-II (013230011), Hematopoietic Stem Cell Laboratory (013022012), Division V (013230900), Cardiology (013230026), Department of Clinical Physiology (Lund) (013013000), Medicine (Lund) (013230025)
- id
- fc28afaa-92ef-4c8f-bbf5-785f43188272 (old id 166461)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17365977&dopt=Abstract
- date added to LUP
- 2016-04-01 15:23:03
- date last changed
- 2024-01-10 14:27:05
@article{fc28afaa-92ef-4c8f-bbf5-785f43188272,
abstract = {{Objectives. To find the time-to-peak for creatine kinase MBmass (CKMB) and cardiac troponin T (cTnT) after acute reperfusion, to compare peak and cumulative values to estimate infarct size (IS), and to evaluate clinical routine sampling for assessment of IS. Design. Acute primary percutaneous coronary intervention (PCI) was performed in 38 patients with first-time myocardial infarction. In 21 patients, CKMB and cTnT were acquired before PCI and at 1.5, 3, 6, 12, 18, 24, and 48 hours thereafter. In 17 patients, clinical routine samples were acquired at arrival, and at 10 and 20 h. IS was assessed by delayed contrast-enhanced MRI (DE- MRI). Results. Time-to-peak was 7.6 +/- 3.6 h for CKMB and 8.1 +/- 3.4 h for cTnT. Peak values correlated strongly to cumulative values (r(s) = 0.97-0.98) as well as to DE-MRI (r(s) = 0.8 - 0.82). Clinical routine sampling showed lower r(s) values (0.47 - 0.60). Conclusions. Peak values are likely captured if CKMB and cTnT are acquired at 3, 6, and 12 h after acute PCI. These peak values can be used to estimate myocardial infarct size after acute PCI.}},
author = {{Hedström, Erik and Åström-Olsson, Karin and Öhlin, Hans and Frogner, Fredrik and Carlsson, Marcus and Billgren, Therese and Jovinge, Stefan and Cain, Peter and Wagner, Galen S and Arheden, Håkan}},
issn = {{1651-2006}},
language = {{eng}},
number = {{1}},
pages = {{44--50}},
publisher = {{Taylor & Francis}},
series = {{Scandinavian Cardiovascular Journal}},
title = {{Peak CKMB and cTnT accurately estimates myocardial infarct size after reperfusion.}},
url = {{http://dx.doi.org/10.1080/14017430601071849}},
doi = {{10.1080/14017430601071849}},
volume = {{41}},
year = {{2007}},
}