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Impaired nerve regeneration and Schwann cell activation after repair with tension.

Yi, Chuanjun LU and Dahlin, Lars LU (2010) In NeuroReport 21. p.958-962
Abstract
The aim was to investigate the relation between axonal outgrowth (neurofilaments) and Schwann cell activation (activating transcription factor 3) and apoptosis (caspase 3) 10 days after nerve repair with no, minor (3 mm defect) and moderate (6 mm defect) tension in rat sciatic nerve using immunohistochemistry. After repair with no tension, axons grew 11.75 mm, but repair with minor and moderate tension impaired axonal outgrowth by 29 and 48%, respectively, with a reduced number of activating transcription factor 3 stained and an increased number of caspase 3 stained Schwann cells. Axonal outgrowth correlated with activation of and inversely with apoptosis of Schwann cells. Tension induces impaired activation of Schwann cells, and a higher... (More)
The aim was to investigate the relation between axonal outgrowth (neurofilaments) and Schwann cell activation (activating transcription factor 3) and apoptosis (caspase 3) 10 days after nerve repair with no, minor (3 mm defect) and moderate (6 mm defect) tension in rat sciatic nerve using immunohistochemistry. After repair with no tension, axons grew 11.75 mm, but repair with minor and moderate tension impaired axonal outgrowth by 29 and 48%, respectively, with a reduced number of activating transcription factor 3 stained and an increased number of caspase 3 stained Schwann cells. Axonal outgrowth correlated with activation of and inversely with apoptosis of Schwann cells. Tension induces impaired activation of Schwann cells, and a higher amount of apoptotic Schwann cells, with a subsequent deteriorated axonal outgrowth. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
NeuroReport
volume
21
pages
958 - 962
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000281816700011
  • pmid:20729767
  • scopus:77956419526
ISSN
1473-558X
DOI
10.1097/WNR.0b013e32833e787f
language
English
LU publication?
yes
id
66609a6d-a984-4c67-9ec8-f8bfbeddad6b (old id 1665094)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20729767?dopt=Abstract
date added to LUP
2010-09-03 11:07:05
date last changed
2018-05-29 11:43:34
@article{66609a6d-a984-4c67-9ec8-f8bfbeddad6b,
  abstract     = {The aim was to investigate the relation between axonal outgrowth (neurofilaments) and Schwann cell activation (activating transcription factor 3) and apoptosis (caspase 3) 10 days after nerve repair with no, minor (3 mm defect) and moderate (6 mm defect) tension in rat sciatic nerve using immunohistochemistry. After repair with no tension, axons grew 11.75 mm, but repair with minor and moderate tension impaired axonal outgrowth by 29 and 48%, respectively, with a reduced number of activating transcription factor 3 stained and an increased number of caspase 3 stained Schwann cells. Axonal outgrowth correlated with activation of and inversely with apoptosis of Schwann cells. Tension induces impaired activation of Schwann cells, and a higher amount of apoptotic Schwann cells, with a subsequent deteriorated axonal outgrowth.},
  author       = {Yi, Chuanjun and Dahlin, Lars},
  issn         = {1473-558X},
  language     = {eng},
  pages        = {958--962},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {NeuroReport},
  title        = {Impaired nerve regeneration and Schwann cell activation after repair with tension.},
  url          = {http://dx.doi.org/10.1097/WNR.0b013e32833e787f},
  volume       = {21},
  year         = {2010},
}