Advanced

The clinical use of N-terminal-pro brain natriuretic peptide in elderly patients with mental illness.

Nilsson, Karin LU ; Gustafson, Lars LU and Hultberg, Björn LU (2010) In Clinical Biochemistry 43. p.1282-1286
Abstract
BACKGROUND: Serum N-terminal-pro brain natriuretic peptide (NT-proBNP) is regarded as a marker of vascular disease and has previously been shown to exhibit an increased frequency of pathological values in elderly patients with mental illness with vascular disease compared to patients without vascular disease. Vascular disease plays an important role in cognitive impairment in elderly patients with mental illness. METHOD: We have investigated the relation between NT-proBNP, vascular disease and cognition in consecutively enrolled elderly patients with mental illness. RESULTS: NT-proBNP level is increased in patients with vascular disease compared to patients without vascular disease, and a logistic regression analysis showed that NT-proBNP... (More)
BACKGROUND: Serum N-terminal-pro brain natriuretic peptide (NT-proBNP) is regarded as a marker of vascular disease and has previously been shown to exhibit an increased frequency of pathological values in elderly patients with mental illness with vascular disease compared to patients without vascular disease. Vascular disease plays an important role in cognitive impairment in elderly patients with mental illness. METHOD: We have investigated the relation between NT-proBNP, vascular disease and cognition in consecutively enrolled elderly patients with mental illness. RESULTS: NT-proBNP level is increased in patients with vascular disease compared to patients without vascular disease, and a logistic regression analysis showed that NT-proBNP was a significant predictor of vascular disease. However, NT-proBNP level did not predict cognition as assessed by MMSE score. NT-proBNP level also showed a highly significant relation to mortality in all patients. CONCLUSION: Determinations of NT-proBNP could be used in elderly patients with mental illness to detect patients in need of control and treatment of vascular risk factors. The levels of NT-proBNP may also provide prognostic information. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Biochemistry
volume
43
pages
1282 - 1286
publisher
Elsevier
external identifiers
  • wos:000283041500003
  • pmid:20727348
  • scopus:77957376224
ISSN
1873-2933
DOI
10.1016/j.clinbiochem.2010.08.011
language
English
LU publication?
yes
id
5f34ad36-cec1-4800-95a8-56f15afd738c (old id 1665129)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20727348?dopt=Abstract
date added to LUP
2010-09-03 11:01:51
date last changed
2018-05-29 10:12:35
@article{5f34ad36-cec1-4800-95a8-56f15afd738c,
  abstract     = {BACKGROUND: Serum N-terminal-pro brain natriuretic peptide (NT-proBNP) is regarded as a marker of vascular disease and has previously been shown to exhibit an increased frequency of pathological values in elderly patients with mental illness with vascular disease compared to patients without vascular disease. Vascular disease plays an important role in cognitive impairment in elderly patients with mental illness. METHOD: We have investigated the relation between NT-proBNP, vascular disease and cognition in consecutively enrolled elderly patients with mental illness. RESULTS: NT-proBNP level is increased in patients with vascular disease compared to patients without vascular disease, and a logistic regression analysis showed that NT-proBNP was a significant predictor of vascular disease. However, NT-proBNP level did not predict cognition as assessed by MMSE score. NT-proBNP level also showed a highly significant relation to mortality in all patients. CONCLUSION: Determinations of NT-proBNP could be used in elderly patients with mental illness to detect patients in need of control and treatment of vascular risk factors. The levels of NT-proBNP may also provide prognostic information.},
  author       = {Nilsson, Karin and Gustafson, Lars and Hultberg, Björn},
  issn         = {1873-2933},
  language     = {eng},
  pages        = {1282--1286},
  publisher    = {Elsevier},
  series       = {Clinical Biochemistry},
  title        = {The clinical use of N-terminal-pro brain natriuretic peptide in elderly patients with mental illness.},
  url          = {http://dx.doi.org/10.1016/j.clinbiochem.2010.08.011},
  volume       = {43},
  year         = {2010},
}