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Early changes in the hypothalamic region in prodromal Huntington disease revealed by MRI analysis.

Soneson, Charlotte LU ; Fontes, Magnus LU ; Zhou, Yongxia LU ; Denisov, Vladimir LU ; Paulsen, Jane S; Kirik, Deniz LU and Petersén, Åsa LU (2010) In Neurobiology of Disease 40. p.531-543
Abstract
Huntington disease (HD) is a fatal neurodegenerative disorder caused by an expanded CAG repeat. Its length can be used to estimate the time of clinical diagnosis, which is defined by overt motor symptoms. Non-motor symptoms begin before motor onset, and involve changes in hypothalamus-regulated functions such as sleep, emotion and metabolism. Therefore we hypothesized that hypothalamic changes occur already prior to the clinical diagnosis. We performed voxel-based morphometry and logistic regression analyses of cross-sectional MR images from 220 HD gene carriers and 75 controls in the Predict-HD study. We show that changes in the hypothalamic region are detectable before clinical diagnosis and that its grey matter contents alone are... (More)
Huntington disease (HD) is a fatal neurodegenerative disorder caused by an expanded CAG repeat. Its length can be used to estimate the time of clinical diagnosis, which is defined by overt motor symptoms. Non-motor symptoms begin before motor onset, and involve changes in hypothalamus-regulated functions such as sleep, emotion and metabolism. Therefore we hypothesized that hypothalamic changes occur already prior to the clinical diagnosis. We performed voxel-based morphometry and logistic regression analyses of cross-sectional MR images from 220 HD gene carriers and 75 controls in the Predict-HD study. We show that changes in the hypothalamic region are detectable before clinical diagnosis and that its grey matter contents alone are sufficient to distinguish HD gene carriers from control cases. In conclusion, our study shows, for the first time, that alterations in grey matter contents in the hypothalamic region occur at least a decade before clinical diagnosis in HD using MRI. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Neurobiology of Disease
volume
40
pages
531 - 543
publisher
Elsevier
external identifiers
  • wos:000283836900003
  • pmid:20682340
  • scopus:77957790499
ISSN
0969-9961
DOI
10.1016/j.nbd.2010.07.013
language
English
LU publication?
yes
id
5d0bb868-cad7-4315-853f-31c4d259460c (old id 1665628)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20682340?dopt=Abstract
date added to LUP
2010-09-02 10:14:46
date last changed
2018-06-24 04:48:24
@article{5d0bb868-cad7-4315-853f-31c4d259460c,
  abstract     = {Huntington disease (HD) is a fatal neurodegenerative disorder caused by an expanded CAG repeat. Its length can be used to estimate the time of clinical diagnosis, which is defined by overt motor symptoms. Non-motor symptoms begin before motor onset, and involve changes in hypothalamus-regulated functions such as sleep, emotion and metabolism. Therefore we hypothesized that hypothalamic changes occur already prior to the clinical diagnosis. We performed voxel-based morphometry and logistic regression analyses of cross-sectional MR images from 220 HD gene carriers and 75 controls in the Predict-HD study. We show that changes in the hypothalamic region are detectable before clinical diagnosis and that its grey matter contents alone are sufficient to distinguish HD gene carriers from control cases. In conclusion, our study shows, for the first time, that alterations in grey matter contents in the hypothalamic region occur at least a decade before clinical diagnosis in HD using MRI.},
  author       = {Soneson, Charlotte and Fontes, Magnus and Zhou, Yongxia and Denisov, Vladimir and Paulsen, Jane S and Kirik, Deniz and Petersén, Åsa},
  issn         = {0969-9961},
  language     = {eng},
  pages        = {531--543},
  publisher    = {Elsevier},
  series       = {Neurobiology of Disease},
  title        = {Early changes in the hypothalamic region in prodromal Huntington disease revealed by MRI analysis.},
  url          = {http://dx.doi.org/10.1016/j.nbd.2010.07.013},
  volume       = {40},
  year         = {2010},
}