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Inherited susceptibility to acute pyelonephritis: a family study of urinary tract infection.

Lundstedt, Ann-Charlotte LU ; Leijonhufvud, Irene LU ; Ragnarsdottir, Bryndis LU ; Karpman, Diana LU ; Andersson, Bjorn and Svanborg, Catharina LU (2007) In Journal of Infectious Diseases 195(8). p.1227-1234
Abstract
Background. Urinary tract infections (UTIs) are important causes of morbidity and death. The present study investigated whether genetic factors influence susceptibility to acute pyelonephritis (APN). CXCR1 expression was investigated as a factor predisposing to APN, because low CXCR1 expression has been associated with disease susceptibility in mice and disease-prone children. Methods. The families of APN-prone children (n=130) and of age-matched control subjects without UTI (n=101) were studied. Three- generation pedigrees of UTI-associated morbidity were established by means of structured interviews of the families. CXCR1 expression was quantified by flow cytometric analysis of peripheral blood neutrophils obtained from family members... (More)
Background. Urinary tract infections (UTIs) are important causes of morbidity and death. The present study investigated whether genetic factors influence susceptibility to acute pyelonephritis (APN). CXCR1 expression was investigated as a factor predisposing to APN, because low CXCR1 expression has been associated with disease susceptibility in mice and disease-prone children. Methods. The families of APN-prone children (n=130) and of age-matched control subjects without UTI (n=101) were studied. Three- generation pedigrees of UTI-associated morbidity were established by means of structured interviews of the families. CXCR1 expression was quantified by flow cytometric analysis of peripheral blood neutrophils obtained from family members and control subjects. Results. APN was significantly more common in the family members of the APN-prone children (20 [15%] of 130 family members) than in the relatives of the control subjects (3 [3%] of 101 family members) (P <.002). Acute cystitis, in contrast, occurred with equal frequency in both groups (19%; P=1.0). Some families included many affected individuals, consistent with a dominant pattern of inheritance, whereas other families showed a recessive pattern of disease susceptibility. CXCR1 expression was significantly lower in the APN-prone children and in their relatives than in pediatric and adult control subjects (P < .0001). Conclusions. Our results suggest that susceptibility to APN is inherited and that low CXCR1 expression might predispose to disease. (Less)
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author
organization
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Contribution to journal
publication status
published
subject
in
Journal of Infectious Diseases
volume
195
issue
8
pages
1227 - 1234
publisher
Oxford University Press
external identifiers
  • wos:000245405100022
  • scopus:34047216519
ISSN
1537-6613
DOI
10.1086/512620
language
English
LU publication?
yes
id
8256c25b-3800-4bff-9f56-77917a4aca32 (old id 166581)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17357062&dopt=Abstract
date added to LUP
2007-07-04 10:05:43
date last changed
2017-06-25 04:23:16
@article{8256c25b-3800-4bff-9f56-77917a4aca32,
  abstract     = {Background. Urinary tract infections (UTIs) are important causes of morbidity and death. The present study investigated whether genetic factors influence susceptibility to acute pyelonephritis (APN). CXCR1 expression was investigated as a factor predisposing to APN, because low CXCR1 expression has been associated with disease susceptibility in mice and disease-prone children. Methods. The families of APN-prone children (n=130) and of age-matched control subjects without UTI (n=101) were studied. Three- generation pedigrees of UTI-associated morbidity were established by means of structured interviews of the families. CXCR1 expression was quantified by flow cytometric analysis of peripheral blood neutrophils obtained from family members and control subjects. Results. APN was significantly more common in the family members of the APN-prone children (20 [15%] of 130 family members) than in the relatives of the control subjects (3 [3%] of 101 family members) (P &lt;.002). Acute cystitis, in contrast, occurred with equal frequency in both groups (19%; P=1.0). Some families included many affected individuals, consistent with a dominant pattern of inheritance, whereas other families showed a recessive pattern of disease susceptibility. CXCR1 expression was significantly lower in the APN-prone children and in their relatives than in pediatric and adult control subjects (P &lt; .0001). Conclusions. Our results suggest that susceptibility to APN is inherited and that low CXCR1 expression might predispose to disease.},
  author       = {Lundstedt, Ann-Charlotte and Leijonhufvud, Irene and Ragnarsdottir, Bryndis and Karpman, Diana and Andersson, Bjorn and Svanborg, Catharina},
  issn         = {1537-6613},
  language     = {eng},
  number       = {8},
  pages        = {1227--1234},
  publisher    = {Oxford University Press},
  series       = {Journal of Infectious Diseases},
  title        = {Inherited susceptibility to acute pyelonephritis: a family study of urinary tract infection.},
  url          = {http://dx.doi.org/10.1086/512620},
  volume       = {195},
  year         = {2007},
}