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Reduced orexin levels in the cerebrospinal fluid of suicidal patients with major depressive disorder.

Brundin, Lena LU ; Björkqvist, Maria LU ; Petersén, Åsa LU and Träskman Bendz, Lil LU (2007) In European Neuropsychopharmacology 17(Mar 6). p.573-579
Abstract
Orexins are neuropeptides selectively expressed in a small number of neurons in the lateral–posterior hypothalamus. We measured orexin-A in the cerebrospinal fluid (CSF) of 66 patients with major depressive disorder (MDD), dysthymia and adjustment disorder after a suicide attempt. Blood samples confirmed that the patients were free from antidepressive and neuroleptic medication at the time of the lumbar punctures. CSF levels of orexin-A were significantly lower in patients with MDD than in patients with adjustment disorder and dysthymia. Orexin correlated significantly with CSF levels of somatostatin, delta sleep inducing peptide-like immunoreactivity (DSIP-LI) and corticotrophin releasing factor (CRF), but not with leptin or vasopressin.... (More)
Orexins are neuropeptides selectively expressed in a small number of neurons in the lateral–posterior hypothalamus. We measured orexin-A in the cerebrospinal fluid (CSF) of 66 patients with major depressive disorder (MDD), dysthymia and adjustment disorder after a suicide attempt. Blood samples confirmed that the patients were free from antidepressive and neuroleptic medication at the time of the lumbar punctures. CSF levels of orexin-A were significantly lower in patients with MDD than in patients with adjustment disorder and dysthymia. Orexin correlated significantly with CSF levels of somatostatin, delta sleep inducing peptide-like immunoreactivity (DSIP-LI) and corticotrophin releasing factor (CRF), but not with leptin or vasopressin. Plasma levels of thyroid-stimulating hormone (TSH) were not reduced in MDD patients, and did not correlate with CSF-orexin. Our results suggest that suicidal patients with MDD have distinct neurobiological features, involving compromised levels of hypothalamic peptides regulating the state of arousal. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
Hypocretin, Orexin, Depression, Hypothalamus, Suicide, CSF
in
European Neuropsychopharmacology
volume
17
issue
Mar 6
pages
573 - 579
publisher
Elsevier
external identifiers
  • wos:000248980500002
  • scopus:34447531745
ISSN
1873-7862
DOI
10.1016/j.euroneuro.2007.01.005
language
English
LU publication?
yes
id
f5f64495-f165-4339-b40f-054153d874bc (old id 166712)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17346943&dopt=Abstract
date added to LUP
2007-07-11 08:47:44
date last changed
2017-11-19 03:31:58
@article{f5f64495-f165-4339-b40f-054153d874bc,
  abstract     = {Orexins are neuropeptides selectively expressed in a small number of neurons in the lateral–posterior hypothalamus. We measured orexin-A in the cerebrospinal fluid (CSF) of 66 patients with major depressive disorder (MDD), dysthymia and adjustment disorder after a suicide attempt. Blood samples confirmed that the patients were free from antidepressive and neuroleptic medication at the time of the lumbar punctures. CSF levels of orexin-A were significantly lower in patients with MDD than in patients with adjustment disorder and dysthymia. Orexin correlated significantly with CSF levels of somatostatin, delta sleep inducing peptide-like immunoreactivity (DSIP-LI) and corticotrophin releasing factor (CRF), but not with leptin or vasopressin. Plasma levels of thyroid-stimulating hormone (TSH) were not reduced in MDD patients, and did not correlate with CSF-orexin. Our results suggest that suicidal patients with MDD have distinct neurobiological features, involving compromised levels of hypothalamic peptides regulating the state of arousal.},
  author       = {Brundin, Lena and Björkqvist, Maria and Petersén, Åsa and Träskman Bendz, Lil},
  issn         = {1873-7862},
  keyword      = {Hypocretin,Orexin,Depression,Hypothalamus,Suicide,CSF},
  language     = {eng},
  number       = {Mar 6},
  pages        = {573--579},
  publisher    = {Elsevier},
  series       = {European Neuropsychopharmacology},
  title        = {Reduced orexin levels in the cerebrospinal fluid of suicidal patients with major depressive disorder.},
  url          = {http://dx.doi.org/10.1016/j.euroneuro.2007.01.005},
  volume       = {17},
  year         = {2007},
}