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Novel aspects of vitamin C: how important is glypican-1 recycling?

Fransson, Lars-Åke LU and Mani, Katrin LU (2007) In Trends in Molecular Medicine 13(4). p.143-149
Abstract
The reduced form of vitamin C, ascorbic acid, is well known for its function as an antioxidant and as a protective agent against scurvy. However, many recent studies indicate other functions for vitamin C in mammalian cells. Novel findings provide possible explanations for observed beneficial effects of a high intake of vitamin C on cell growth, gene transcription, host resistance to infection, uptake of polyamines and clearance of misfolded proteins. Vitamin C exerts its effects indirectly via hypoxia-inducible factor, nitric oxide synthase and the heparan sulfate proteoglycan glypican-1, which is deglycanated in a vitamin C- and copper-dependent reaction.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Trends in Molecular Medicine
volume
13
issue
4
pages
143 - 149
publisher
Elsevier
external identifiers
  • wos:000246124000002
  • scopus:34047097248
ISSN
1471-4914
DOI
10.1016/j.molmed.2007.02.005
language
English
LU publication?
yes
id
3898d0d4-0e85-48b4-ba3e-d91a399de8eb (old id 166752)
date added to LUP
2007-07-12 10:51:31
date last changed
2017-08-06 04:25:27
@article{3898d0d4-0e85-48b4-ba3e-d91a399de8eb,
  abstract     = {The reduced form of vitamin C, ascorbic acid, is well known for its function as an antioxidant and as a protective agent against scurvy. However, many recent studies indicate other functions for vitamin C in mammalian cells. Novel findings provide possible explanations for observed beneficial effects of a high intake of vitamin C on cell growth, gene transcription, host resistance to infection, uptake of polyamines and clearance of misfolded proteins. Vitamin C exerts its effects indirectly via hypoxia-inducible factor, nitric oxide synthase and the heparan sulfate proteoglycan glypican-1, which is deglycanated in a vitamin C- and copper-dependent reaction.},
  author       = {Fransson, Lars-Åke and Mani, Katrin},
  issn         = {1471-4914},
  language     = {eng},
  number       = {4},
  pages        = {143--149},
  publisher    = {Elsevier},
  series       = {Trends in Molecular Medicine},
  title        = {Novel aspects of vitamin C: how important is glypican-1 recycling?},
  url          = {http://dx.doi.org/10.1016/j.molmed.2007.02.005},
  volume       = {13},
  year         = {2007},
}