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In vivo optical characterization of human prostate tissue using near-infrared time-resolved spectroscopy.

Svensson, Tomas LU ; Andersson-Engels, Stefan LU ; Einarsdóttír, Margrét and Svanberg, Katarina LU (2007) In Journal of Biomedical Optics 12(1). p.014022-014022
Abstract
The development of photodynamic therapy into a modality for treatment of prostate cancer calls for reliable optical dosimetry. We employ, for the first time, interstitial time-resolved spectroscopy to determine in vivo optical properties of human prostate tissue. Nine patients are included in the study, and measurements are conducted prior to primary brachytherapy treatment of prostate cancer. Intrasubject variability is examined by measuring across three tissue volumes within each prostate. The time-resolved instrumentation proves its usefulness by producing good signal levels in all measurements. We are able to present consistent values on reduced scattering coefficients (mu(s)'), absorption coefficients (mu(a)), and effective... (More)
The development of photodynamic therapy into a modality for treatment of prostate cancer calls for reliable optical dosimetry. We employ, for the first time, interstitial time-resolved spectroscopy to determine in vivo optical properties of human prostate tissue. Nine patients are included in the study, and measurements are conducted prior to primary brachytherapy treatment of prostate cancer. Intrasubject variability is examined by measuring across three tissue volumes within each prostate. The time-resolved instrumentation proves its usefulness by producing good signal levels in all measurements. We are able to present consistent values on reduced scattering coefficients (mu(s)'), absorption coefficients (mu(a)), and effective attenuation (mu(eff)) at the wavelengths 660, 786, and 916 nm. At 660 nm, mu(s)' is found to be 9 +/- 2 cm(-1), and mu(a) is 0.5 +/- 0.1 cm-1. Derived values of mu(eff) are in the range of 3 to 4 cm-1 at 660 nm, a result in good agreement with previously published steady state data. Total hemoglobin concentration (THC) and oxygen saturation are spectroscopically determined using derived absorption coefficients. Derived THC values are fairly variable (215 +/- 65 mu M), while derived values of oxygen saturation are gathered around 75% (76 +/- 4%). Intrasubject variations in derived parameters correlate (qualitatively) with the heterogeneity exhibited in acquired ultrasound images. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
photon migration, human prostate, hemoglobin, in vivo, optical properties, spectroscopy, time-resolved
in
Journal of Biomedical Optics
volume
12
issue
1
pages
014022 - 014022
publisher
Published by SPIE--the International Society for Optical Engineering in cooperation with International Biomedical Optics Society
external identifiers
  • wos:000245505400023
  • scopus:34247623589
ISSN
1083-3668
DOI
10.1117/1.2435175
language
English
LU publication?
yes
id
24d38156-a16b-46f5-88a9-16b1cf31b913 (old id 166775)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17343497&dopt=Abstract
date added to LUP
2007-07-24 10:53:49
date last changed
2017-09-03 03:57:53
@article{24d38156-a16b-46f5-88a9-16b1cf31b913,
  abstract     = {The development of photodynamic therapy into a modality for treatment of prostate cancer calls for reliable optical dosimetry. We employ, for the first time, interstitial time-resolved spectroscopy to determine in vivo optical properties of human prostate tissue. Nine patients are included in the study, and measurements are conducted prior to primary brachytherapy treatment of prostate cancer. Intrasubject variability is examined by measuring across three tissue volumes within each prostate. The time-resolved instrumentation proves its usefulness by producing good signal levels in all measurements. We are able to present consistent values on reduced scattering coefficients (mu(s)'), absorption coefficients (mu(a)), and effective attenuation (mu(eff)) at the wavelengths 660, 786, and 916 nm. At 660 nm, mu(s)' is found to be 9 +/- 2 cm(-1), and mu(a) is 0.5 +/- 0.1 cm-1. Derived values of mu(eff) are in the range of 3 to 4 cm-1 at 660 nm, a result in good agreement with previously published steady state data. Total hemoglobin concentration (THC) and oxygen saturation are spectroscopically determined using derived absorption coefficients. Derived THC values are fairly variable (215 +/- 65 mu M), while derived values of oxygen saturation are gathered around 75% (76 +/- 4%). Intrasubject variations in derived parameters correlate (qualitatively) with the heterogeneity exhibited in acquired ultrasound images.},
  author       = {Svensson, Tomas and Andersson-Engels, Stefan and Einarsdóttír, Margrét and Svanberg, Katarina},
  issn         = {1083-3668},
  keyword      = {photon migration,human prostate,hemoglobin,in vivo,optical properties,spectroscopy,time-resolved},
  language     = {eng},
  number       = {1},
  pages        = {014022--014022},
  publisher    = {Published by SPIE--the International Society for Optical Engineering in cooperation with International Biomedical Optics Society},
  series       = {Journal of Biomedical Optics},
  title        = {In vivo optical characterization of human prostate tissue using near-infrared time-resolved spectroscopy.},
  url          = {http://dx.doi.org/10.1117/1.2435175},
  volume       = {12},
  year         = {2007},
}