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Neurochemical measures co-vary with personality traits: Forensic psychiatric findings replicated in a general population sample

Nilsson, Thomas; Bromander, Sara; Anckarsater, Rolf; Kristiansson, Marianne; Forsman, Anders; Blennow, Kaj; Zetterberg, Henrik; Anckarsäter, Henrik LU and Wass, Caroline (2010) In Psychiatry Research 178(3). p.525-530
Abstract
Neurobiological markers in cerebrospinal fluid (CSF) and in serum, previously found to co-vary with destructive personality traits in violent offenders, were explored in a general population sample of 21 patients undergoing knee surgery. Results on the Karolinska Scales of Personality (KSP) and the Temperament and Character Inventory (TCI) were compared with CSF/serum albumin ratios and serum concentrations of beta-trace protein (beta TP) (as markers for blood-brain barrier (BBB) permeability), to CSF/serum albumin ratios between the dopamine and serotonin metabolites homovanillic acid (HVA)/5-hydroxyindoleacetic acid (HIM) and to CSF and serum ratios between activated thyroid hormone (T3) and its precursor T4. Serum beta TP concentrations... (More)
Neurobiological markers in cerebrospinal fluid (CSF) and in serum, previously found to co-vary with destructive personality traits in violent offenders, were explored in a general population sample of 21 patients undergoing knee surgery. Results on the Karolinska Scales of Personality (KSP) and the Temperament and Character Inventory (TCI) were compared with CSF/serum albumin ratios and serum concentrations of beta-trace protein (beta TP) (as markers for blood-brain barrier (BBB) permeability), to CSF/serum albumin ratios between the dopamine and serotonin metabolites homovanillic acid (HVA)/5-hydroxyindoleacetic acid (HIM) and to CSF and serum ratios between activated thyroid hormone (T3) and its precursor T4. Serum beta TP concentrations correlated with CSF/serum albumin ratios (P=0.018), but not with preoperative serum creatinine concentrations. Serum beta TP correlated significantly with Monotony Avoidance and Impulsiveness: CSF HVA/5-HIAA ratios with Irritability and low Cooperativeness. The beta TP is a potential serum marker for the integrity of the BBB that does not necessitate lumbar puncture. Thyroid hormones did not correlate with personality traits. As reported in forensic psychiatric patients, aggressive, unempathic personality traits were thus associated with increased dopaminergic activity in relation to the serotonergic activity and impulsivity to increased BBB permeability also in a general population group. (C) 2010 Elsevier Ireland Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Dopamine, metabolites, Monoamine, Beta-trace protein (beta TP), Blood-brain barrier, Personality, Thyroid hormones, Serotonin
in
Psychiatry Research
volume
178
issue
3
pages
525 - 530
publisher
Elsevier
external identifiers
  • wos:000281181400013
  • scopus:77955173243
ISSN
1872-7123
DOI
10.1016/j.psychres.2010.05.016
language
English
LU publication?
yes
id
fa6f5577-6f51-4ed8-831a-250a6074af1b (old id 1672593)
date added to LUP
2010-09-23 13:37:20
date last changed
2018-05-29 10:36:09
@article{fa6f5577-6f51-4ed8-831a-250a6074af1b,
  abstract     = {Neurobiological markers in cerebrospinal fluid (CSF) and in serum, previously found to co-vary with destructive personality traits in violent offenders, were explored in a general population sample of 21 patients undergoing knee surgery. Results on the Karolinska Scales of Personality (KSP) and the Temperament and Character Inventory (TCI) were compared with CSF/serum albumin ratios and serum concentrations of beta-trace protein (beta TP) (as markers for blood-brain barrier (BBB) permeability), to CSF/serum albumin ratios between the dopamine and serotonin metabolites homovanillic acid (HVA)/5-hydroxyindoleacetic acid (HIM) and to CSF and serum ratios between activated thyroid hormone (T3) and its precursor T4. Serum beta TP concentrations correlated with CSF/serum albumin ratios (P=0.018), but not with preoperative serum creatinine concentrations. Serum beta TP correlated significantly with Monotony Avoidance and Impulsiveness: CSF HVA/5-HIAA ratios with Irritability and low Cooperativeness. The beta TP is a potential serum marker for the integrity of the BBB that does not necessitate lumbar puncture. Thyroid hormones did not correlate with personality traits. As reported in forensic psychiatric patients, aggressive, unempathic personality traits were thus associated with increased dopaminergic activity in relation to the serotonergic activity and impulsivity to increased BBB permeability also in a general population group. (C) 2010 Elsevier Ireland Ltd. All rights reserved.},
  author       = {Nilsson, Thomas and Bromander, Sara and Anckarsater, Rolf and Kristiansson, Marianne and Forsman, Anders and Blennow, Kaj and Zetterberg, Henrik and Anckarsäter, Henrik and Wass, Caroline},
  issn         = {1872-7123},
  keyword      = {Dopamine,metabolites,Monoamine,Beta-trace protein (beta TP),Blood-brain barrier,Personality,Thyroid hormones,Serotonin},
  language     = {eng},
  number       = {3},
  pages        = {525--530},
  publisher    = {Elsevier},
  series       = {Psychiatry Research},
  title        = {Neurochemical measures co-vary with personality traits: Forensic psychiatric findings replicated in a general population sample},
  url          = {http://dx.doi.org/10.1016/j.psychres.2010.05.016},
  volume       = {178},
  year         = {2010},
}