No Association of VEGF Polymorphims with Alzheimer's Disease
(2010) In NeuroMolecular Medicine 12(3). p.224-228- Abstract
- The vascular hypothesis of Alzheimer's disease (AD) has brought the vascular endothelial growth factor (VEGF) into focus. The genomic region including the VEGF gene has been linked to AD and single nucleotide polymorphisms (SNPs) of the VEGF have in previous studies been associated with AD risk. To further evaluate these findings, we genotyped two SNPs in the VEGF gene (rs699947 [-2578]) and rs1570360 [-1154]) by TaqMan Allelic Discrimination in a study sample including AD patients (n = 801) and controls (n = 286). In a subgroup of the population these SNPs were analyzed in relation to APOE epsilon 4 genotype, to cerebrospinal fluid biomarkers (T-tau, P-tau, and beta(42)-Amyloid) as well as to neuropathological markers for AD... (More)
- The vascular hypothesis of Alzheimer's disease (AD) has brought the vascular endothelial growth factor (VEGF) into focus. The genomic region including the VEGF gene has been linked to AD and single nucleotide polymorphisms (SNPs) of the VEGF have in previous studies been associated with AD risk. To further evaluate these findings, we genotyped two SNPs in the VEGF gene (rs699947 [-2578]) and rs1570360 [-1154]) by TaqMan Allelic Discrimination in a study sample including AD patients (n = 801) and controls (n = 286). In a subgroup of the population these SNPs were analyzed in relation to APOE epsilon 4 genotype, to cerebrospinal fluid biomarkers (T-tau, P-tau, and beta(42)-Amyloid) as well as to neuropathological markers for AD (neurofibrillary tangles and senile plaques). No significant associations with risk for AD or any of the studied biomarkers could be found in this study, thus not supporting VEGF as being a major risk gene for AD. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1673014
- author
- Landgren, Sara ; Palmer, Mona Seibt ; Skoog, Ingemar ; Minthon, Lennart LU ; Wallin, Anders ; Andreasen, Niels ; Zetterberg, Madeleine ; Blennow, Kaj and Zetterberg, Henrik
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Alzheimer's disease, VEGF, beta-Amyloid, Tau
- in
- NeuroMolecular Medicine
- volume
- 12
- issue
- 3
- pages
- 224 - 228
- publisher
- Humana Press
- external identifiers
-
- wos:000281259200003
- scopus:78649921495
- pmid:19842071
- ISSN
- 1535-1084
- DOI
- 10.1007/s12017-009-8096-8
- language
- English
- LU publication?
- yes
- id
- 4c78db2f-d365-463c-a3b5-d993a1f81079 (old id 1673014)
- date added to LUP
- 2016-04-01 10:07:56
- date last changed
- 2022-01-25 20:02:56
@article{4c78db2f-d365-463c-a3b5-d993a1f81079, abstract = {{The vascular hypothesis of Alzheimer's disease (AD) has brought the vascular endothelial growth factor (VEGF) into focus. The genomic region including the VEGF gene has been linked to AD and single nucleotide polymorphisms (SNPs) of the VEGF have in previous studies been associated with AD risk. To further evaluate these findings, we genotyped two SNPs in the VEGF gene (rs699947 [-2578]) and rs1570360 [-1154]) by TaqMan Allelic Discrimination in a study sample including AD patients (n = 801) and controls (n = 286). In a subgroup of the population these SNPs were analyzed in relation to APOE epsilon 4 genotype, to cerebrospinal fluid biomarkers (T-tau, P-tau, and beta(42)-Amyloid) as well as to neuropathological markers for AD (neurofibrillary tangles and senile plaques). No significant associations with risk for AD or any of the studied biomarkers could be found in this study, thus not supporting VEGF as being a major risk gene for AD.}}, author = {{Landgren, Sara and Palmer, Mona Seibt and Skoog, Ingemar and Minthon, Lennart and Wallin, Anders and Andreasen, Niels and Zetterberg, Madeleine and Blennow, Kaj and Zetterberg, Henrik}}, issn = {{1535-1084}}, keywords = {{Alzheimer's disease; VEGF; beta-Amyloid; Tau}}, language = {{eng}}, number = {{3}}, pages = {{224--228}}, publisher = {{Humana Press}}, series = {{NeuroMolecular Medicine}}, title = {{No Association of VEGF Polymorphims with Alzheimer's Disease}}, url = {{http://dx.doi.org/10.1007/s12017-009-8096-8}}, doi = {{10.1007/s12017-009-8096-8}}, volume = {{12}}, year = {{2010}}, }