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No Association of VEGF Polymorphims with Alzheimer's Disease

Landgren, Sara; Palmer, Mona Seibt; Skoog, Ingemar; Minthon, Lennart LU ; Wallin, Anders; Andreasen, Niels; Zetterberg, Madeleine; Blennow, Kaj and Zetterberg, Henrik (2010) In NeuroMolecular Medicine 12(3). p.224-228
Abstract
The vascular hypothesis of Alzheimer's disease (AD) has brought the vascular endothelial growth factor (VEGF) into focus. The genomic region including the VEGF gene has been linked to AD and single nucleotide polymorphisms (SNPs) of the VEGF have in previous studies been associated with AD risk. To further evaluate these findings, we genotyped two SNPs in the VEGF gene (rs699947 [-2578]) and rs1570360 [-1154]) by TaqMan Allelic Discrimination in a study sample including AD patients (n = 801) and controls (n = 286). In a subgroup of the population these SNPs were analyzed in relation to APOE epsilon 4 genotype, to cerebrospinal fluid biomarkers (T-tau, P-tau, and beta(42)-Amyloid) as well as to neuropathological markers for AD... (More)
The vascular hypothesis of Alzheimer's disease (AD) has brought the vascular endothelial growth factor (VEGF) into focus. The genomic region including the VEGF gene has been linked to AD and single nucleotide polymorphisms (SNPs) of the VEGF have in previous studies been associated with AD risk. To further evaluate these findings, we genotyped two SNPs in the VEGF gene (rs699947 [-2578]) and rs1570360 [-1154]) by TaqMan Allelic Discrimination in a study sample including AD patients (n = 801) and controls (n = 286). In a subgroup of the population these SNPs were analyzed in relation to APOE epsilon 4 genotype, to cerebrospinal fluid biomarkers (T-tau, P-tau, and beta(42)-Amyloid) as well as to neuropathological markers for AD (neurofibrillary tangles and senile plaques). No significant associations with risk for AD or any of the studied biomarkers could be found in this study, thus not supporting VEGF as being a major risk gene for AD. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alzheimer's disease, VEGF, beta-Amyloid, Tau
in
NeuroMolecular Medicine
volume
12
issue
3
pages
224 - 228
publisher
Humana Press
external identifiers
  • wos:000281259200003
  • scopus:78649921495
ISSN
1535-1084
DOI
10.1007/s12017-009-8096-8
language
English
LU publication?
yes
id
4c78db2f-d365-463c-a3b5-d993a1f81079 (old id 1673014)
date added to LUP
2010-09-23 12:26:34
date last changed
2018-05-29 10:57:16
@article{4c78db2f-d365-463c-a3b5-d993a1f81079,
  abstract     = {The vascular hypothesis of Alzheimer's disease (AD) has brought the vascular endothelial growth factor (VEGF) into focus. The genomic region including the VEGF gene has been linked to AD and single nucleotide polymorphisms (SNPs) of the VEGF have in previous studies been associated with AD risk. To further evaluate these findings, we genotyped two SNPs in the VEGF gene (rs699947 [-2578]) and rs1570360 [-1154]) by TaqMan Allelic Discrimination in a study sample including AD patients (n = 801) and controls (n = 286). In a subgroup of the population these SNPs were analyzed in relation to APOE epsilon 4 genotype, to cerebrospinal fluid biomarkers (T-tau, P-tau, and beta(42)-Amyloid) as well as to neuropathological markers for AD (neurofibrillary tangles and senile plaques). No significant associations with risk for AD or any of the studied biomarkers could be found in this study, thus not supporting VEGF as being a major risk gene for AD.},
  author       = {Landgren, Sara and Palmer, Mona Seibt and Skoog, Ingemar and Minthon, Lennart and Wallin, Anders and Andreasen, Niels and Zetterberg, Madeleine and Blennow, Kaj and Zetterberg, Henrik},
  issn         = {1535-1084},
  keyword      = {Alzheimer's disease,VEGF,beta-Amyloid,Tau},
  language     = {eng},
  number       = {3},
  pages        = {224--228},
  publisher    = {Humana Press},
  series       = {NeuroMolecular Medicine},
  title        = {No Association of VEGF Polymorphims with Alzheimer's Disease},
  url          = {http://dx.doi.org/10.1007/s12017-009-8096-8},
  volume       = {12},
  year         = {2010},
}