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Kinesin Light Chain 1 Gene Haplotypes in Three Conformational Diseases

von Otter, Malin; Landgren, Sara; Nilsson, Staffan; Lundvall, Caroline; Minthon, Lennart LU ; Bogdanovic, Nenad; Andreasen, Niels; Gustafson, Deborah R.; Skoog, Ingmar and Wallin, Anders, et al. (2010) In NeuroMolecular Medicine 12(3). p.229-236
Abstract
A functional intracellular transport system is essential to maintain cell shape and function especially in elongated cells, e.g. neurons and lens fibre cells. Impaired intracellular transport has been suggested as a common pathological mechanism for age-related diseases characterised by protein aggregation. Here, we hypothesise that common genetic variation in the transport protein kinesin may influence the risk of Parkinson's disease (PD), Alzheimer's disease (AD) and age-related cataract. This case-control study involves a PD material (165 cases and 190 controls), an AD material (653 cases and 845 controls) and a cataract material (495 cases and 183 controls). Genetic variation in the kinesin light chain 1-encoding gene (KLC1) was tagged... (More)
A functional intracellular transport system is essential to maintain cell shape and function especially in elongated cells, e.g. neurons and lens fibre cells. Impaired intracellular transport has been suggested as a common pathological mechanism for age-related diseases characterised by protein aggregation. Here, we hypothesise that common genetic variation in the transport protein kinesin may influence the risk of Parkinson's disease (PD), Alzheimer's disease (AD) and age-related cataract. This case-control study involves a PD material (165 cases and 190 controls), an AD material (653 cases and 845 controls) and a cataract material (495 cases and 183 controls). Genetic variation in the kinesin light chain 1-encoding gene (KLC1) was tagged by six tag single nucleotide polymorphisms (SNPs). Single SNPs and haplotypes were analysed for associations with disease risk, age parameters, mini-mental state examination scores and cerebrospinal fluid biomarkers for AD using logistic or linear regression. Genetic variation in KLC1 did not influence risk of PD. Weak associations with risk of AD were seen for rs8007903 and rs3212079 (P (c) = 0.04 and P (c) = 0.02, respectively). Two SNPs (rs8007903 and rs8702) influenced risk of cataract (P (c) = 0.0007 and P (c) = 0.04, respectively). However, the allele of rs8007903 that caused increased risk of AD caused reduced risk of cataract, speaking against a common functional effect of this particular SNP in the two diseases. Haplotype analyses did not add significantly to the associations found in the single SNP analyses. Altogether, these results do not convincingly support KLC1 as a major susceptibility gene in any of the studied diseases, although there is a small effect of KLC1 in relation to cataract. (Less)
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published
subject
keywords
KLC1, Kinesin, Cataract, Parkinson's disease, Alzheimer's disease, Haplotype, SNP
in
NeuroMolecular Medicine
volume
12
issue
3
pages
229 - 236
publisher
Humana Press
external identifiers
  • wos:000281259200004
  • scopus:78649978365
ISSN
1535-1084
DOI
10.1007/s12017-009-8103-0
language
English
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yes
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bbd833c0-6c85-4977-9b18-2e41701087b1 (old id 1673025)
date added to LUP
2010-09-23 12:27:47
date last changed
2018-05-29 09:34:55
@article{bbd833c0-6c85-4977-9b18-2e41701087b1,
  abstract     = {A functional intracellular transport system is essential to maintain cell shape and function especially in elongated cells, e.g. neurons and lens fibre cells. Impaired intracellular transport has been suggested as a common pathological mechanism for age-related diseases characterised by protein aggregation. Here, we hypothesise that common genetic variation in the transport protein kinesin may influence the risk of Parkinson's disease (PD), Alzheimer's disease (AD) and age-related cataract. This case-control study involves a PD material (165 cases and 190 controls), an AD material (653 cases and 845 controls) and a cataract material (495 cases and 183 controls). Genetic variation in the kinesin light chain 1-encoding gene (KLC1) was tagged by six tag single nucleotide polymorphisms (SNPs). Single SNPs and haplotypes were analysed for associations with disease risk, age parameters, mini-mental state examination scores and cerebrospinal fluid biomarkers for AD using logistic or linear regression. Genetic variation in KLC1 did not influence risk of PD. Weak associations with risk of AD were seen for rs8007903 and rs3212079 (P (c) = 0.04 and P (c) = 0.02, respectively). Two SNPs (rs8007903 and rs8702) influenced risk of cataract (P (c) = 0.0007 and P (c) = 0.04, respectively). However, the allele of rs8007903 that caused increased risk of AD caused reduced risk of cataract, speaking against a common functional effect of this particular SNP in the two diseases. Haplotype analyses did not add significantly to the associations found in the single SNP analyses. Altogether, these results do not convincingly support KLC1 as a major susceptibility gene in any of the studied diseases, although there is a small effect of KLC1 in relation to cataract.},
  author       = {von Otter, Malin and Landgren, Sara and Nilsson, Staffan and Lundvall, Caroline and Minthon, Lennart and Bogdanovic, Nenad and Andreasen, Niels and Gustafson, Deborah R. and Skoog, Ingmar and Wallin, Anders and Hakansson, Anna and Nissbrandt, Hans and Zetterberg, Madeleine and Tasa, Gunnar and Blennow, Kaj and Zetterberg, Henrik},
  issn         = {1535-1084},
  keyword      = {KLC1,Kinesin,Cataract,Parkinson's disease,Alzheimer's disease,Haplotype,SNP},
  language     = {eng},
  number       = {3},
  pages        = {229--236},
  publisher    = {Humana Press},
  series       = {NeuroMolecular Medicine},
  title        = {Kinesin Light Chain 1 Gene Haplotypes in Three Conformational Diseases},
  url          = {http://dx.doi.org/10.1007/s12017-009-8103-0},
  volume       = {12},
  year         = {2010},
}