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Prediction of bone loss using biochemical markers of bone turnover.

Lenora, J; Ivaska, Kaisa LU ; Obrant, Karl LU and Gerdhem, Paul LU (2007) In Osteoporosis International 18(9). p.1297-1305
Abstract
The association between baseline levels of eleven bone turnover markers and 5-year rate of bone density change was prospectively studied in a population-based sample of 601 75-year-old women. Several bone formation and resorption markers as well as urinary osteocalcin were modestly correlated to rate of bone density change. Introduction Prediction of bone loss by bone turnover markers (BTMs) has been investigated with conflicting results. There is limited information in the elderly. Methods Eleven bone turnover markers were analyzed in 75year old women in the OPRA study (n= 601) and compared to the 5-year change of areal bone mineral density (aBMD) in seven skeletal regions. Results Annual aBMD change varied between +0.4% ( spine) and... (More)
The association between baseline levels of eleven bone turnover markers and 5-year rate of bone density change was prospectively studied in a population-based sample of 601 75-year-old women. Several bone formation and resorption markers as well as urinary osteocalcin were modestly correlated to rate of bone density change. Introduction Prediction of bone loss by bone turnover markers (BTMs) has been investigated with conflicting results. There is limited information in the elderly. Methods Eleven bone turnover markers were analyzed in 75year old women in the OPRA study (n= 601) and compared to the 5-year change of areal bone mineral density (aBMD) in seven skeletal regions. Results Annual aBMD change varied between +0.4% ( spine) and -2.0% ( femoral neck). Significant associations (p < 0.01) were found for four different serum osteocalcins (S-OCs) ( standardized regression coefficient -0.20 to -0.22), urinary deoxypyridinoline (-0.19), serum TRACP5b (-0.19), serum CTX- I (-0.21), two of the three urinary osteocalcins (U-OCs) (-0.16) and aBMD change of the leg region ( derived from the total body measurement). After adjustment for baseline aBMD, associations were found for all S-OCs (-0.11 to -0.16), two of the three U-OCs (-0.14 to -0.16) and aBMD change at the total hip, and for three of the four S-OCs (-0.14 to -0.15), S-TRACP5b (-0.11), two of the three U-OCs (-0.14 to -0.15) and aBMD change at the femoral neck. There were no significant results concerning aBMD change at the spine. Conclusion This study indicates that BTMs are correlated with aBMD loss in some skeletal regions in elderly women. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
bone turnover markers, bone loss, elderly, bone density
in
Osteoporosis International
volume
18
issue
9
pages
1297 - 1305
publisher
Springer
external identifiers
  • wos:000249900000018
  • scopus:34548126988
ISSN
1433-2965
DOI
10.1007/s00198-007-0379-z
language
English
LU publication?
yes
id
c015eef3-7cc1-4c12-844c-2b93424246a2 (old id 167547)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17440674&dopt=Abstract
date added to LUP
2007-07-25 10:41:24
date last changed
2017-07-09 04:21:30
@article{c015eef3-7cc1-4c12-844c-2b93424246a2,
  abstract     = {The association between baseline levels of eleven bone turnover markers and 5-year rate of bone density change was prospectively studied in a population-based sample of 601 75-year-old women. Several bone formation and resorption markers as well as urinary osteocalcin were modestly correlated to rate of bone density change. Introduction Prediction of bone loss by bone turnover markers (BTMs) has been investigated with conflicting results. There is limited information in the elderly. Methods Eleven bone turnover markers were analyzed in 75year old women in the OPRA study (n= 601) and compared to the 5-year change of areal bone mineral density (aBMD) in seven skeletal regions. Results Annual aBMD change varied between +0.4% ( spine) and -2.0% ( femoral neck). Significant associations (p &lt; 0.01) were found for four different serum osteocalcins (S-OCs) ( standardized regression coefficient -0.20 to -0.22), urinary deoxypyridinoline (-0.19), serum TRACP5b (-0.19), serum CTX- I (-0.21), two of the three urinary osteocalcins (U-OCs) (-0.16) and aBMD change of the leg region ( derived from the total body measurement). After adjustment for baseline aBMD, associations were found for all S-OCs (-0.11 to -0.16), two of the three U-OCs (-0.14 to -0.16) and aBMD change at the total hip, and for three of the four S-OCs (-0.14 to -0.15), S-TRACP5b (-0.11), two of the three U-OCs (-0.14 to -0.15) and aBMD change at the femoral neck. There were no significant results concerning aBMD change at the spine. Conclusion This study indicates that BTMs are correlated with aBMD loss in some skeletal regions in elderly women.},
  author       = {Lenora, J and Ivaska, Kaisa and Obrant, Karl and Gerdhem, Paul},
  issn         = {1433-2965},
  keyword      = {bone turnover markers,bone loss,elderly,bone density},
  language     = {eng},
  number       = {9},
  pages        = {1297--1305},
  publisher    = {Springer},
  series       = {Osteoporosis International},
  title        = {Prediction of bone loss using biochemical markers of bone turnover.},
  url          = {http://dx.doi.org/10.1007/s00198-007-0379-z},
  volume       = {18},
  year         = {2007},
}