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Occupational exposure to pesticides and bile tract carcinoma in men: results from a European multicenter case-control study

Schmeisser, N.; Kaerlev, L.; Bourdon-Raverdy, N.; Ganry, O.; Llopis-Gonzalez, A.; Guenel, P.; Hardell, L.; Merletti, F.; Zambon, P. and Morales-Suarez-Varela, M., et al. (2010) In Cancer Causes and Control 21(9). p.1493-1502
Abstract
Objectives To estimate the associations between occupational exposure to pesticides and extrahepatic biliary tract carcinoma in men, a population-based case-control study was carried out. Methods Cases (n = 104), aged 35-70, diagnosed in 1995-1997, were sampled by active reporting systems from hospitals. Controls (n = 1,401) were a random sample of the general male population. Information on occupation and confounding factors was obtained by questionnaires. Exposures were quantified with respect to time, application methods, and use of personal protective equipment. Intensity was evaluated by using a published algorithm which weighted the exposure assigned according to the use of personal protective equipment and mode of application.... (More)
Objectives To estimate the associations between occupational exposure to pesticides and extrahepatic biliary tract carcinoma in men, a population-based case-control study was carried out. Methods Cases (n = 104), aged 35-70, diagnosed in 1995-1997, were sampled by active reporting systems from hospitals. Controls (n = 1,401) were a random sample of the general male population. Information on occupation and confounding factors was obtained by questionnaires. Exposures were quantified with respect to time, application methods, and use of personal protective equipment. Intensity was evaluated by using a published algorithm which weighted the exposure assigned according to the use of personal protective equipment and mode of application. Logistic regression analyses were conducted adjusted for gallstones, age, and country. Results Being ever exposed to pesticides resulted in an odds ratio (OR) of 1.0 [95%-confidence interval (CI) 0.6-1.6]. A modestly elevated risk was found for backpack mounted sprayers OR = 1.4 [95% CI 0.7-2.6] and vine farmers OR = 2.5 [95% CI 0.9-7.2]. Using time periods and exposure frequency as intensity measure, no elevated risks were found. The only exception was year of maximum exposure which yielded an OR of 1.6 [95% CI 0.7-3.5]. However, no clear trend was observed in this analysis. Conclusions This study does not rule out that pesticide exposure represents an occupational risk factor for extrahepatic biliary tract carcinoma, but no indication of a strong association was observed. Some modes of exposure were weakly, albeit not significantly associated with carcinoma risk. The observed estimates of effects may be influenced by a lack of precise exposure assessment. Different chemical compositions of pesticides were utilized during a long time span of pesticide exposure, and it should be considered that the exposure is assessed with substantial uncertainty that could non-differential and bias results toward the null. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Environment, Gallbladder cancer, Bile tract cancer, Agriculture
in
Cancer Causes and Control
volume
21
issue
9
pages
1493 - 1502
publisher
Springer
external identifiers
  • wos:000280902000016
  • scopus:77956968349
ISSN
1573-7225
DOI
10.1007/s10552-010-9578-6
language
English
LU publication?
yes
id
81c47c18-909b-4906-8f54-dc2e71646411 (old id 1676893)
date added to LUP
2010-09-21 10:14:05
date last changed
2018-05-29 09:36:22
@article{81c47c18-909b-4906-8f54-dc2e71646411,
  abstract     = {Objectives To estimate the associations between occupational exposure to pesticides and extrahepatic biliary tract carcinoma in men, a population-based case-control study was carried out. Methods Cases (n = 104), aged 35-70, diagnosed in 1995-1997, were sampled by active reporting systems from hospitals. Controls (n = 1,401) were a random sample of the general male population. Information on occupation and confounding factors was obtained by questionnaires. Exposures were quantified with respect to time, application methods, and use of personal protective equipment. Intensity was evaluated by using a published algorithm which weighted the exposure assigned according to the use of personal protective equipment and mode of application. Logistic regression analyses were conducted adjusted for gallstones, age, and country. Results Being ever exposed to pesticides resulted in an odds ratio (OR) of 1.0 [95%-confidence interval (CI) 0.6-1.6]. A modestly elevated risk was found for backpack mounted sprayers OR = 1.4 [95% CI 0.7-2.6] and vine farmers OR = 2.5 [95% CI 0.9-7.2]. Using time periods and exposure frequency as intensity measure, no elevated risks were found. The only exception was year of maximum exposure which yielded an OR of 1.6 [95% CI 0.7-3.5]. However, no clear trend was observed in this analysis. Conclusions This study does not rule out that pesticide exposure represents an occupational risk factor for extrahepatic biliary tract carcinoma, but no indication of a strong association was observed. Some modes of exposure were weakly, albeit not significantly associated with carcinoma risk. The observed estimates of effects may be influenced by a lack of precise exposure assessment. Different chemical compositions of pesticides were utilized during a long time span of pesticide exposure, and it should be considered that the exposure is assessed with substantial uncertainty that could non-differential and bias results toward the null.},
  author       = {Schmeisser, N. and Kaerlev, L. and Bourdon-Raverdy, N. and Ganry, O. and Llopis-Gonzalez, A. and Guenel, P. and Hardell, L. and Merletti, F. and Zambon, P. and Morales-Suarez-Varela, M. and Olsen, J. and Olsson, Håkan and Vyberg, M. and Ahrens, W.},
  issn         = {1573-7225},
  keyword      = {Environment,Gallbladder cancer,Bile tract cancer,Agriculture},
  language     = {eng},
  number       = {9},
  pages        = {1493--1502},
  publisher    = {Springer},
  series       = {Cancer Causes and Control},
  title        = {Occupational exposure to pesticides and bile tract carcinoma in men: results from a European multicenter case-control study},
  url          = {http://dx.doi.org/10.1007/s10552-010-9578-6},
  volume       = {21},
  year         = {2010},
}