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Characterization of two novel cutaneous human papillomaviruses, HPV93 and HPV96.

Vasiljevic, Natasa LU ; Hazard, Kristina LU ; Eliasson, Linda LU ; Ly, Hoang; Hunziker, Andreas; de Villiers, Ethel-Michele; Norrild, Bodil; Dillner, Joakim LU and Forslund, Ola LU (2007) In Journal of General Virology 88(Pt 5). p.1479-1483
Abstract
Two novel human papillomaviruses (HPVs), HPV93 and HPV96, with genomes of 7450 and 7438 bp, respectively, are described. The Ll open reading frame of HPV93 showed highest identity to HPV24 (79%) and that of HPV96 had highest identity to HPV92 (71 %). Real-time PCR for HPV92, 93 and 96 on stripped biopsies from tumours and healthy skin from 269 immunocompetent patients found HPV DNA in 2.6 % of tumours and in 0.4 % of healthy skin samples. Double infections were observed in two tumours. HPV92 was detected in four, HPV93 in two and HPV96 in three tumours. The range of viral loads spanned from one copy per 45 cells to one copy per 10 000 cells. The E7 proteins of HPV92, 93 and 96 were found to bind the retinoblastoma protein (pRb). These... (More)
Two novel human papillomaviruses (HPVs), HPV93 and HPV96, with genomes of 7450 and 7438 bp, respectively, are described. The Ll open reading frame of HPV93 showed highest identity to HPV24 (79%) and that of HPV96 had highest identity to HPV92 (71 %). Real-time PCR for HPV92, 93 and 96 on stripped biopsies from tumours and healthy skin from 269 immunocompetent patients found HPV DNA in 2.6 % of tumours and in 0.4 % of healthy skin samples. Double infections were observed in two tumours. HPV92 was detected in four, HPV93 in two and HPV96 in three tumours. The range of viral loads spanned from one copy per 45 cells to one copy per 10 000 cells. The E7 proteins of HPV92, 93 and 96 were found to bind the retinoblastoma protein (pRb). These results suggest a possible role for these HPV types in skin carcinogenesis that deserves further study. (Less)
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author
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type
Contribution to journal
publication status
published
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in
Journal of General Virology
volume
88
issue
Pt 5
pages
1479 - 1483
publisher
Society for General Microbiology
external identifiers
  • wos:000246532300011
  • scopus:34248175918
ISSN
1465-2099
DOI
10.1099/vir.0.82679-0
language
English
LU publication?
yes
id
199321a6-1a40-49ff-be33-903ef0d2cd70 (old id 167758)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17412976&dopt=Abstract
date added to LUP
2007-07-27 12:17:24
date last changed
2017-03-19 04:15:33
@article{199321a6-1a40-49ff-be33-903ef0d2cd70,
  abstract     = {Two novel human papillomaviruses (HPVs), HPV93 and HPV96, with genomes of 7450 and 7438 bp, respectively, are described. The Ll open reading frame of HPV93 showed highest identity to HPV24 (79%) and that of HPV96 had highest identity to HPV92 (71 %). Real-time PCR for HPV92, 93 and 96 on stripped biopsies from tumours and healthy skin from 269 immunocompetent patients found HPV DNA in 2.6 % of tumours and in 0.4 % of healthy skin samples. Double infections were observed in two tumours. HPV92 was detected in four, HPV93 in two and HPV96 in three tumours. The range of viral loads spanned from one copy per 45 cells to one copy per 10 000 cells. The E7 proteins of HPV92, 93 and 96 were found to bind the retinoblastoma protein (pRb). These results suggest a possible role for these HPV types in skin carcinogenesis that deserves further study.},
  author       = {Vasiljevic, Natasa and Hazard, Kristina and Eliasson, Linda and Ly, Hoang and Hunziker, Andreas and de Villiers, Ethel-Michele and Norrild, Bodil and Dillner, Joakim and Forslund, Ola},
  issn         = {1465-2099},
  language     = {eng},
  number       = {Pt 5},
  pages        = {1479--1483},
  publisher    = {Society for General Microbiology},
  series       = {Journal of General Virology},
  title        = {Characterization of two novel cutaneous human papillomaviruses, HPV93 and HPV96.},
  url          = {http://dx.doi.org/10.1099/vir.0.82679-0},
  volume       = {88},
  year         = {2007},
}