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Crossed over repair of the femoral sensory and motor branches influences N-CAM

Saito, Harukazu; Kanje, Martin LU and Dahlin, Lars LU (2010) In NeuroReport 21(12). p.841-845
Abstract
N-CAM, expressed by non-myelinating Schwann cells, was investigated by immunohistochemistry in transected rat femoral nerves, which were repaired either using a straight or a crossed over technique. N-CAM staining covered 30 and 11% of the cross-sectional area of and motor branches, respectively, in uninjured nerves. After 3 days there was a transient smaller area of N-CAM staining following both the repairs. After a straight repair N-CAM area increased to the control values in both branches. In contrast, a crossed over repair resulted in a continuous increase of N-CAM in the motor branch, whereas the area in the sensory branch returned slowly to control values. N-CAM is influenced by an intentionally misdirected outgrowth of motor and... (More)
N-CAM, expressed by non-myelinating Schwann cells, was investigated by immunohistochemistry in transected rat femoral nerves, which were repaired either using a straight or a crossed over technique. N-CAM staining covered 30 and 11% of the cross-sectional area of and motor branches, respectively, in uninjured nerves. After 3 days there was a transient smaller area of N-CAM staining following both the repairs. After a straight repair N-CAM area increased to the control values in both branches. In contrast, a crossed over repair resulted in a continuous increase of N-CAM in the motor branch, whereas the area in the sensory branch returned slowly to control values. N-CAM is influenced by an intentionally misdirected outgrowth of motor and sensory axons after nerve repair. NeuroReport 21:841-845 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
neurofilaments, nerve repair, nerve regeneration, N-CAM, axons, misdirection, non-myelinating, Schwann cells
in
NeuroReport
volume
21
issue
12
pages
841 - 845
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000280592900010
  • scopus:77955231671
ISSN
1473-558X
DOI
10.1097/WNR.0b013e32833d40e2
language
English
LU publication?
yes
id
b8d23cd2-08c6-4014-878c-a8af286cf243 (old id 1677879)
date added to LUP
2010-09-21 10:22:12
date last changed
2018-05-29 11:05:41
@article{b8d23cd2-08c6-4014-878c-a8af286cf243,
  abstract     = {N-CAM, expressed by non-myelinating Schwann cells, was investigated by immunohistochemistry in transected rat femoral nerves, which were repaired either using a straight or a crossed over technique. N-CAM staining covered 30 and 11% of the cross-sectional area of and motor branches, respectively, in uninjured nerves. After 3 days there was a transient smaller area of N-CAM staining following both the repairs. After a straight repair N-CAM area increased to the control values in both branches. In contrast, a crossed over repair resulted in a continuous increase of N-CAM in the motor branch, whereas the area in the sensory branch returned slowly to control values. N-CAM is influenced by an intentionally misdirected outgrowth of motor and sensory axons after nerve repair. NeuroReport 21:841-845 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.},
  author       = {Saito, Harukazu and Kanje, Martin and Dahlin, Lars},
  issn         = {1473-558X},
  keyword      = {neurofilaments,nerve repair,nerve regeneration,N-CAM,axons,misdirection,non-myelinating,Schwann cells},
  language     = {eng},
  number       = {12},
  pages        = {841--845},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {NeuroReport},
  title        = {Crossed over repair of the femoral sensory and motor branches influences N-CAM},
  url          = {http://dx.doi.org/10.1097/WNR.0b013e32833d40e2},
  volume       = {21},
  year         = {2010},
}