Advanced

Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm

Gretarsdottir, Solveig; Baas, Annette F.; Thorleifsson, Gudmar; Holm, Hilma; den Heijer, Martin; de Vries, Jean-Paul P. M.; Kranendonk, Steef E.; Zeebregts, Clark J. A. M.; van Sterkenburg, Steven M. and Geelkerken, Robert H., et al. (2010) In Nature Genetics 42(8). p.71-692
Abstract
We performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up of top markers in up to 3,267 individuals with AAAs and 7,451 controls. The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.6 x 10(-10). In tests for association with other vascular diseases, we found that rs7025486[A] is associated with early onset myocardial infarction (OR = 1.18, P = 3.1 x 10(-5)), peripheral arterial disease (OR = 1.14, P = 3.9 x 10(-5)) and pulmonary embolism (OR = 1.20, P = 0.00030), but not with intracranial aneurysm or ischemic stroke. No association was observed between rs7025486[A]... (More)
We performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up of top markers in up to 3,267 individuals with AAAs and 7,451 controls. The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.6 x 10(-10). In tests for association with other vascular diseases, we found that rs7025486[A] is associated with early onset myocardial infarction (OR = 1.18, P = 3.1 x 10(-5)), peripheral arterial disease (OR = 1.14, P = 3.9 x 10(-5)) and pulmonary embolism (OR = 1.20, P = 0.00030), but not with intracranial aneurysm or ischemic stroke. No association was observed between rs7025486[A] and common risk factors for arterial and venous diseases-that is, smoking, lipid levels, obesity, type 2 diabetes and hypertension. Rs7025486 is located within DAB2IP, which encodes an inhibitor of cell growth and survival. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Genetics
volume
42
issue
8
pages
71 - 692
publisher
Nature Publishing Group
external identifiers
  • wos:000280524000014
  • scopus:84947899513
ISSN
1546-1718
DOI
10.1038/ng.622
language
English
LU publication?
yes
id
d7ad61fd-a9d2-4d5f-91f9-0c0fd8eedd89 (old id 1677884)
date added to LUP
2010-09-21 10:27:39
date last changed
2018-06-24 03:58:05
@article{d7ad61fd-a9d2-4d5f-91f9-0c0fd8eedd89,
  abstract     = {We performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up of top markers in up to 3,267 individuals with AAAs and 7,451 controls. The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.6 x 10(-10). In tests for association with other vascular diseases, we found that rs7025486[A] is associated with early onset myocardial infarction (OR = 1.18, P = 3.1 x 10(-5)), peripheral arterial disease (OR = 1.14, P = 3.9 x 10(-5)) and pulmonary embolism (OR = 1.20, P = 0.00030), but not with intracranial aneurysm or ischemic stroke. No association was observed between rs7025486[A] and common risk factors for arterial and venous diseases-that is, smoking, lipid levels, obesity, type 2 diabetes and hypertension. Rs7025486 is located within DAB2IP, which encodes an inhibitor of cell growth and survival.},
  author       = {Gretarsdottir, Solveig and Baas, Annette F. and Thorleifsson, Gudmar and Holm, Hilma and den Heijer, Martin and de Vries, Jean-Paul P. M. and Kranendonk, Steef E. and Zeebregts, Clark J. A. M. and van Sterkenburg, Steven M. and Geelkerken, Robert H. and van Rij, Andre M. and Williams, Michael J. A. and Boll, Albert P. M. and Kostic, Jelena P. and Jonasdottir, Adalbjorg and Jonasdottir, Aslaug and Walters, G. Bragi and Masson, Gisli and Sulem, Patrick and Saemundsdottir, Jona and Mouy, Magali and Magnusson, Kristinn P. and Tromp, Gerard and Elmore, James R. and Sakalihasan, Natzi and Limet, Raymond and Defraigne, Jean-Olivier and Ferrell, Robert E. and Ronkainen, Antti and Ruigrok, Ynte M. and Wijmenga, Cisca and Grobbee, Diederick E. and Shah, Svati H. and Granger, Christopher B. and Quyyumi, Arshed A. and Vaccarino, Viola and Patel, Riyaz S. and Zafari, A. Maziar and Levey, Allan I. and Austin, Harland and Girelli, Domenico and Pignatti, Pier Franco and Olivieri, Oliviero and Martinelli, Nicola and Malerba, Giovanni and Trabetti, Elisabetta and Becker, Lewis C. and Becker, Diane M. and Reilly, Muredach P. and Rader, Daniel J. and Mueller, Thomas and Dieplinger, Benjamin and Haltmayer, Meinhard and Urbonavicius, Sigitas and Lindblad, Bengt and Gottsäter, Anders and Gaetani, Eleonora and Pola, Roberto and Wells, Philip and Rodger, Marc and Forgie, Melissa and Langlois, Nicole and Corral, Javier and Vicente, Vicente and Fontcuberta, Jordi and Espana, Francisco and Grarup, Niels and Jorgensen, Torben and Witte, Daniel R. and Hansen, Torben and Pedersen, Oluf and Aben, Katja K. and de Graaf, Jacqueline and Holewijn, Suzanne and Folkersen, Lasse and Franco-Cereceda, Anders and Eriksson, Per and Collier, David A. and Stefansson, Hreinn and Steinthorsdottir, Valgerdur and Rafnar, Thorunn and Valdimarsson, Einar M. and Magnadottir, Hulda B. and Sveinbjornsdottir, Sigurlaug and Olafsson, Isleifur and Magnusson, Magnus Karl and Palmason, Robert and Haraldsdottir, Vilhelmina and Andersen, Karl and Onundarson, Pall T. and Thorgeirsson, Gudmundur and Kiemeney, Lambertus A. and Powell, Janet T. and Carey, David J. and Kuivaniemi, Helena and Lindholt, Jes S. and Jones, Gregory T. and Kong, Augustine and Blankensteijn, Jan D. and Matthiasson, Stefan E. and Thorsteinsdottir, Unnur and Stefansson, Kari},
  issn         = {1546-1718},
  language     = {eng},
  number       = {8},
  pages        = {71--692},
  publisher    = {Nature Publishing Group},
  series       = {Nature Genetics},
  title        = {Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm},
  url          = {http://dx.doi.org/10.1038/ng.622},
  volume       = {42},
  year         = {2010},
}