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Associations of estradiol and testosterone with serum phosphorus in older men: the Osteoporotic Fractures in Men study

Meng, Jerry; Ohlsson, Claes; Laughlin, Gail A.; Chonchol, Michel; Wassel, Christina L.; Ljunggren, Osten; Karlsson, Magnus LU ; Mellstrom, Dan; Orwoll, Eric S. and Barrett-Connor, Elizabeth, et al. (2010) In Kidney International 78(4). p.415-422
Abstract
Postmenopausal women consistently have higher phosphorus levels than similarly aged men. As it is known that estradiol induces phosphaturia in rodents, we evaluated the cross-sectional association of sex hormones with serum phosphorus in 1346 community-living older men (mean age 76) of which 18% had moderate (stage 3) kidney disease. Using linear regression with serum phosphorus levels as the dependent variable, we found that for each 10 pg/ml higher total estradiol level there was a statistically significant 0.05 mg/dl lower serum phosphorus when adjusted for age, ethnicity, testosterone, sex hormone-binding globulin, calcium, estimated glomerular filtration rate, intact parathyroid hormone, 25(OH) vitamin D, bone mineral density, and... (More)
Postmenopausal women consistently have higher phosphorus levels than similarly aged men. As it is known that estradiol induces phosphaturia in rodents, we evaluated the cross-sectional association of sex hormones with serum phosphorus in 1346 community-living older men (mean age 76) of which 18% had moderate (stage 3) kidney disease. Using linear regression with serum phosphorus levels as the dependent variable, we found that for each 10 pg/ml higher total estradiol level there was a statistically significant 0.05 mg/dl lower serum phosphorus when adjusted for age, ethnicity, testosterone, sex hormone-binding globulin, calcium, estimated glomerular filtration rate, intact parathyroid hormone, 25(OH) vitamin D, bone mineral density, and alkaline phosphatase. These results were similar in individuals with or without chronic kidney disease. Serum testosterone concentrations were also statistically significantly associated with lower serum phosphorus levels. We confirmed these results in an independent sample of 2555 older men, wherein these associations were not attenuated when adjusted for fibroblast growth factor-23 levels. Hence, our study of community-living older men suggests that estradiol may directly or indirectly induce phosphaturia in humans. The mechanism responsible for the association of testosterone with serum phosphorus remains to be determined. Kidney International (2010) 78, 415-422; doi:10.1038/ki.2010.161; published online 9 June 2010 (Less)
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keywords
testosterone, hormones, sex, phosphorus, kidney disease, cardiovascular disease, estradiol
in
Kidney International
volume
78
issue
4
pages
415 - 422
publisher
Nature Publishing Group
external identifiers
  • wos:000280528000012
  • scopus:77955171788
ISSN
1523-1755
DOI
10.1038/ki.2010.161
language
English
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yes
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d398915d-db32-41de-98fe-0a137fce2be4 (old id 1678234)
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2010-09-21 10:10:42
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2018-05-29 09:31:22
@article{d398915d-db32-41de-98fe-0a137fce2be4,
  abstract     = {Postmenopausal women consistently have higher phosphorus levels than similarly aged men. As it is known that estradiol induces phosphaturia in rodents, we evaluated the cross-sectional association of sex hormones with serum phosphorus in 1346 community-living older men (mean age 76) of which 18% had moderate (stage 3) kidney disease. Using linear regression with serum phosphorus levels as the dependent variable, we found that for each 10 pg/ml higher total estradiol level there was a statistically significant 0.05 mg/dl lower serum phosphorus when adjusted for age, ethnicity, testosterone, sex hormone-binding globulin, calcium, estimated glomerular filtration rate, intact parathyroid hormone, 25(OH) vitamin D, bone mineral density, and alkaline phosphatase. These results were similar in individuals with or without chronic kidney disease. Serum testosterone concentrations were also statistically significantly associated with lower serum phosphorus levels. We confirmed these results in an independent sample of 2555 older men, wherein these associations were not attenuated when adjusted for fibroblast growth factor-23 levels. Hence, our study of community-living older men suggests that estradiol may directly or indirectly induce phosphaturia in humans. The mechanism responsible for the association of testosterone with serum phosphorus remains to be determined. Kidney International (2010) 78, 415-422; doi:10.1038/ki.2010.161; published online 9 June 2010},
  author       = {Meng, Jerry and Ohlsson, Claes and Laughlin, Gail A. and Chonchol, Michel and Wassel, Christina L. and Ljunggren, Osten and Karlsson, Magnus and Mellstrom, Dan and Orwoll, Eric S. and Barrett-Connor, Elizabeth and Ix, Joachim H.},
  issn         = {1523-1755},
  keyword      = {testosterone,hormones,sex,phosphorus,kidney disease,cardiovascular disease,estradiol},
  language     = {eng},
  number       = {4},
  pages        = {415--422},
  publisher    = {Nature Publishing Group},
  series       = {Kidney International},
  title        = {Associations of estradiol and testosterone with serum phosphorus in older men: the Osteoporotic Fractures in Men study},
  url          = {http://dx.doi.org/10.1038/ki.2010.161},
  volume       = {78},
  year         = {2010},
}