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Verification that common variation at 2q37.1, 6p25.3, 11q24.1, 15q23, and 19q13.32 influences chronic lymphocytic leukaemia risk

Crowther-Swanepoel, Dalemari; Mansouri, Mahmoud; Enjuanes, Anna; Vega, Ana; Smedby, Karin E.; Ruiz-Ponte, Clara; Jurlander, Jesper; Juliusson, Gunnar LU ; Montserrat, Emilio and Catovsky, Daniel, et al. (2010) In British Journal of Haematology 150(4). p.473-479
Abstract
P>A recent genome wide association study of chronic lymphocytic leukaemia (CLL) provided evidence that common variation at 2q13 (rs17483466), 2q37.1 (rs13397985), 6p25.3 (rs872071), 11q24.1 (rs735665), 15q23 (rs7176508) and 19q13.32 (rs11083846) affects CLL risk. To verify and further explore the relationship between these variants and CLL risk we genotyped case-control datasets from Spain and Sweden (824 cases, 850 controls). Combined data provided statistically significant support for an association between genotypes at rs13397985, rs872071, rs735665, rs7176508 and rs11083846 and CLL risk. CLL risk increased with increasing numbers of risk alleles (P-trend = 1 center dot 40 x 10-15), consistent with a polygenic model of disease... (More)
P>A recent genome wide association study of chronic lymphocytic leukaemia (CLL) provided evidence that common variation at 2q13 (rs17483466), 2q37.1 (rs13397985), 6p25.3 (rs872071), 11q24.1 (rs735665), 15q23 (rs7176508) and 19q13.32 (rs11083846) affects CLL risk. To verify and further explore the relationship between these variants and CLL risk we genotyped case-control datasets from Spain and Sweden (824 cases, 850 controls). Combined data provided statistically significant support for an association between genotypes at rs13397985, rs872071, rs735665, rs7176508 and rs11083846 and CLL risk. CLL risk increased with increasing numbers of risk alleles (P-trend = 1 center dot 40 x 10-15), consistent with a polygenic model of disease susceptibility. These data validate the relationship between common variation and risk of CLL. (Less)
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Contribution to journal
publication status
published
subject
keywords
chronic lymphocytic leukaemia, risk, genotype, genome wide association
in
British Journal of Haematology
volume
150
issue
4
pages
473 - 479
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000280629300009
  • scopus:77955129094
ISSN
0007-1048
DOI
10.1111/j.1365-2141.2010.08270.x
language
English
LU publication?
yes
id
d4ddae80-a095-4df1-a6f1-a239634c60e8 (old id 1678490)
date added to LUP
2010-09-21 08:44:05
date last changed
2018-05-29 11:58:53
@article{d4ddae80-a095-4df1-a6f1-a239634c60e8,
  abstract     = {P>A recent genome wide association study of chronic lymphocytic leukaemia (CLL) provided evidence that common variation at 2q13 (rs17483466), 2q37.1 (rs13397985), 6p25.3 (rs872071), 11q24.1 (rs735665), 15q23 (rs7176508) and 19q13.32 (rs11083846) affects CLL risk. To verify and further explore the relationship between these variants and CLL risk we genotyped case-control datasets from Spain and Sweden (824 cases, 850 controls). Combined data provided statistically significant support for an association between genotypes at rs13397985, rs872071, rs735665, rs7176508 and rs11083846 and CLL risk. CLL risk increased with increasing numbers of risk alleles (P-trend = 1 center dot 40 x 10-15), consistent with a polygenic model of disease susceptibility. These data validate the relationship between common variation and risk of CLL.},
  author       = {Crowther-Swanepoel, Dalemari and Mansouri, Mahmoud and Enjuanes, Anna and Vega, Ana and Smedby, Karin E. and Ruiz-Ponte, Clara and Jurlander, Jesper and Juliusson, Gunnar and Montserrat, Emilio and Catovsky, Daniel and Campo, Elias and Carracedo, Angel and Rosenquist, Richard and Houlston, Richard S.},
  issn         = {0007-1048},
  keyword      = {chronic lymphocytic leukaemia,risk,genotype,genome wide association},
  language     = {eng},
  number       = {4},
  pages        = {473--479},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {British Journal of Haematology},
  title        = {Verification that common variation at 2q37.1, 6p25.3, 11q24.1, 15q23, and 19q13.32 influences chronic lymphocytic leukaemia risk},
  url          = {http://dx.doi.org/10.1111/j.1365-2141.2010.08270.x},
  volume       = {150},
  year         = {2010},
}