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Rapid and long-term induction of effector immediate early genes (BDNF, Neuritin and Arc) in peri-infarct cortex and dentate gyrus after ischemic injury in rat brain.

Rickhag, Mattias LU ; Teilum, Maria LU and Wieloch, Tadeusz LU (2007) In Brain Research 1151. p.203-210
Abstract
The genomic response following brain ischemia is very complex and involves activation of both protective and detrimental signaling pathways. Immediate early genes (IEGs) represent the first wave of gene expression following ischemia and are induced in extensive regions of the ischemic brain including cerebral cortex and hippocampus. Brain-derived neurotrophic factor (BDNF), Neuritin and Activity-regulated cytoskeleton-associated protein (Arc) belong to a subgroup of immediate early genes implicated in synaptic plasticity known as effector immediate early genes. Here, we investigated the spatial and temporal activation pattern for these genes during the first 24 h of reperfusion following 2-h occlusion of the middle cerebral artery.... (More)
The genomic response following brain ischemia is very complex and involves activation of both protective and detrimental signaling pathways. Immediate early genes (IEGs) represent the first wave of gene expression following ischemia and are induced in extensive regions of the ischemic brain including cerebral cortex and hippocampus. Brain-derived neurotrophic factor (BDNF), Neuritin and Activity-regulated cytoskeleton-associated protein (Arc) belong to a subgroup of immediate early genes implicated in synaptic plasticity known as effector immediate early genes. Here, we investigated the spatial and temporal activation pattern for these genes during the first 24 h of reperfusion following 2-h occlusion of the middle cerebral artery. Neuritin showed a persistent activation in frontal-cingulate cortex while Arc displayed a biphasic response. Also, in dentate gyrus, activation was observed at 0–6 h of reperfusion for Neuritin and 0–12 h of reperfusion for Arc while BDNF was induced 0–9 h of reperfusion. Our study demonstrates a rapid and long-term activation of effector immediate early genes in distinct brain areas following ischemic injury in rat. Effector gene activation may be part of long-term synaptic responses of ischemic brain tissue. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Gene expression, Focal brain ischemia, Hippocampus, Frontal-cingulate cortex, Plasticity
in
Brain Research
volume
1151
pages
203 - 210
publisher
Elsevier
external identifiers
  • wos:000246828300021
  • scopus:34248198866
ISSN
1872-6240
DOI
10.1016/j.brainres.2007.03.005
language
English
LU publication?
yes
id
e112f815-a536-40c8-81db-c39e35ecda57 (old id 167880)
date added to LUP
2007-07-16 16:15:20
date last changed
2017-10-22 03:46:05
@article{e112f815-a536-40c8-81db-c39e35ecda57,
  abstract     = {The genomic response following brain ischemia is very complex and involves activation of both protective and detrimental signaling pathways. Immediate early genes (IEGs) represent the first wave of gene expression following ischemia and are induced in extensive regions of the ischemic brain including cerebral cortex and hippocampus. Brain-derived neurotrophic factor (BDNF), Neuritin and Activity-regulated cytoskeleton-associated protein (Arc) belong to a subgroup of immediate early genes implicated in synaptic plasticity known as effector immediate early genes. Here, we investigated the spatial and temporal activation pattern for these genes during the first 24 h of reperfusion following 2-h occlusion of the middle cerebral artery. Neuritin showed a persistent activation in frontal-cingulate cortex while Arc displayed a biphasic response. Also, in dentate gyrus, activation was observed at 0–6 h of reperfusion for Neuritin and 0–12 h of reperfusion for Arc while BDNF was induced 0–9 h of reperfusion. Our study demonstrates a rapid and long-term activation of effector immediate early genes in distinct brain areas following ischemic injury in rat. Effector gene activation may be part of long-term synaptic responses of ischemic brain tissue.},
  author       = {Rickhag, Mattias and Teilum, Maria and Wieloch, Tadeusz},
  issn         = {1872-6240},
  keyword      = {Gene expression,Focal brain ischemia,Hippocampus,Frontal-cingulate cortex,Plasticity},
  language     = {eng},
  pages        = {203--210},
  publisher    = {Elsevier},
  series       = {Brain Research},
  title        = {Rapid and long-term induction of effector immediate early genes (BDNF, Neuritin and Arc) in peri-infarct cortex and dentate gyrus after ischemic injury in rat brain.},
  url          = {http://dx.doi.org/10.1016/j.brainres.2007.03.005},
  volume       = {1151},
  year         = {2007},
}