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No excess risk for colorectal cancer among subjects seropositive for the JC polyomavirus.

Lundstig, Annika LU ; Stattin, Pär; Persson, Kenneth LU ; Sasnauskas, Kestutis; Viscidi, Raphael P; Gislefoss, Randi Elin and Dillner, Joakim LU (2007) In International Journal of Cancer 121(5). p.1098-1102
Abstract
The human polymnaviruses JC virus (JCV) and BK virus (BKV) are oncogenic in experimental systems and commonly infect humans. JCV DNA has been reported to be present in human colon mucosa and in colorectal cancers. To investigate whether the risk for colorectal cancer is associated with JCV or BKV infection, we performed a case-control study nested in the Janus biobank, a cohort of 330,000 healthy Norwegian subjects. A 30-year prospective follow-up using registry linkages identified 386 men with colorectal cancer who had baseline serum samples taken >3 months before diagnosis. Control subjects were matched for sex, age and date of blood sampling and county of residence. Seropositivity for JCV or BKV had high (97-100%) sensitivity for... (More)
The human polymnaviruses JC virus (JCV) and BK virus (BKV) are oncogenic in experimental systems and commonly infect humans. JCV DNA has been reported to be present in human colon mucosa and in colorectal cancers. To investigate whether the risk for colorectal cancer is associated with JCV or BKV infection, we performed a case-control study nested in the Janus biobank, a cohort of 330,000 healthy Norwegian subjects. A 30-year prospective follow-up using registry linkages identified 386 men with colorectal cancer who had baseline serum samples taken >3 months before diagnosis. Control subjects were matched for sex, age and date of blood sampling and county of residence. Seropositivity for JCV or BKV had high (97-100%) sensitivity for detection of viral DNA-positive subjects and discriminated the different polyomaviruses. Seropositivity was mostly stable over time in serial samples. The relative risk for colorectal cancer among JCV seropositive subjects was 0.9 (95% CI: 0.7-1.3) and the BKV-associated relative risk was 1.1 (95% CI: 0.8-1.5). Determining seropositivity using alternative cutoffs also found no evidence of excess risk. In summary, this prospective study found no association between JCV or BKV infections and excess risk for colorectal cancer. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
virus-like particles, studies, biobank, seroepiderniology, tumour virology prospective
in
International Journal of Cancer
volume
121
issue
5
pages
1098 - 1102
publisher
John Wiley & Sons
external identifiers
  • wos:000248242500023
  • scopus:34547104831
ISSN
0020-7136
DOI
10.1002/ijc.22770
language
English
LU publication?
yes
id
656c120c-4d12-49ea-87fa-55cb86a9f5a7 (old id 168489)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17471560&dopt=Abstract
date added to LUP
2007-07-25 16:18:47
date last changed
2017-02-19 03:23:59
@article{656c120c-4d12-49ea-87fa-55cb86a9f5a7,
  abstract     = {The human polymnaviruses JC virus (JCV) and BK virus (BKV) are oncogenic in experimental systems and commonly infect humans. JCV DNA has been reported to be present in human colon mucosa and in colorectal cancers. To investigate whether the risk for colorectal cancer is associated with JCV or BKV infection, we performed a case-control study nested in the Janus biobank, a cohort of 330,000 healthy Norwegian subjects. A 30-year prospective follow-up using registry linkages identified 386 men with colorectal cancer who had baseline serum samples taken >3 months before diagnosis. Control subjects were matched for sex, age and date of blood sampling and county of residence. Seropositivity for JCV or BKV had high (97-100%) sensitivity for detection of viral DNA-positive subjects and discriminated the different polyomaviruses. Seropositivity was mostly stable over time in serial samples. The relative risk for colorectal cancer among JCV seropositive subjects was 0.9 (95% CI: 0.7-1.3) and the BKV-associated relative risk was 1.1 (95% CI: 0.8-1.5). Determining seropositivity using alternative cutoffs also found no evidence of excess risk. In summary, this prospective study found no association between JCV or BKV infections and excess risk for colorectal cancer.},
  author       = {Lundstig, Annika and Stattin, Pär and Persson, Kenneth and Sasnauskas, Kestutis and Viscidi, Raphael P and Gislefoss, Randi Elin and Dillner, Joakim},
  issn         = {0020-7136},
  keyword      = {virus-like particles,studies,biobank,seroepiderniology,tumour virology
prospective},
  language     = {eng},
  number       = {5},
  pages        = {1098--1102},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {No excess risk for colorectal cancer among subjects seropositive for the JC polyomavirus.},
  url          = {http://dx.doi.org/10.1002/ijc.22770},
  volume       = {121},
  year         = {2007},
}