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Plasma ANP and BNP during exercise in patients with major depressive disorder and in healthy controls.

Wisén, Anita LU ; Ekberg, Kristina LU ; Wohlfart, Björn LU ; Ekman, Rolf and Westrin, Åsa LU (2011) In Journal of Affective Disorders 129(1-3). p.371-375
Abstract
BACKGROUND: Increased levels of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) have been shown to reduce the hormones in the HPA axis. In this study we addressed the question whether patients with unmedicated major depressive disorder (MDD) might have altered baseline levels of these natriuretic peptides and an altered response to acute exercise. METHODS: An incremental exercise test was performed in 18 patients with MDD and in 18 healthy controls. Plasma concentrations of ANP and BNP were determined at rest, during the exercise test and 30min post exercise using immunoradiometric assays. RESULTS: During the exercise test the concentrations of ANP and BNP increased significantly in both groups. The MDD group showed... (More)
BACKGROUND: Increased levels of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) have been shown to reduce the hormones in the HPA axis. In this study we addressed the question whether patients with unmedicated major depressive disorder (MDD) might have altered baseline levels of these natriuretic peptides and an altered response to acute exercise. METHODS: An incremental exercise test was performed in 18 patients with MDD and in 18 healthy controls. Plasma concentrations of ANP and BNP were determined at rest, during the exercise test and 30min post exercise using immunoradiometric assays. RESULTS: During the exercise test the concentrations of ANP and BNP increased significantly in both groups. The MDD group showed significantly lower levels of ANP than the controls at rest, at maximal work rate and post exercise and of BNP at rest and at maximal work rate. The dynamic changes of both ANP and BNP, respectively, from baseline to maximal work rate were significantly lower in the MDD group. A slightly lower (non-significant) maximal work rate was observed in the MDD group compared with the controls. LIMITATIONS: Group sizes are relatively limited. CONCLUSION: Lower concentrations of ANP and BNP during rest and exercise were observed in the MDD patients together with a decreased dynamic response to maximal exercise. Hypothetically, the reduced ANP and BNP concentration contributes to the high hormone levels in the HPA system seen in depressive disorders. Of interest for future research is whether physical training might increase the levels of ANP and BNP and thereby diminish depressive symptoms. (Less)
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Exercise, Major depressive disorder (MDD), Atrial natriuretic peptide (ANP), Brain natriuretic peptide (BNP)
in
Journal of Affective Disorders
volume
129
issue
1-3
pages
371 - 375
publisher
Elsevier
external identifiers
  • wos:000288293400053
  • pmid:20875919
  • scopus:79851514620
  • pmid:20875919
ISSN
1573-2517
DOI
10.1016/j.jad.2010.09.002
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Physiotherapy (Closed 2012) (013042000), Department of Clinical Physiology (Lund) (013013000), Psychiatry (Lund) (013303000)
id
b611c48b-94ae-40b0-a584-34c30048a7a0 (old id 1687737)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20875919?dopt=Abstract
http://www.sciencedirect.com/science/article/pii/S0165032710005707
date added to LUP
2016-04-01 11:10:39
date last changed
2021-09-29 01:36:27
@article{b611c48b-94ae-40b0-a584-34c30048a7a0,
  abstract     = {BACKGROUND: Increased levels of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) have been shown to reduce the hormones in the HPA axis. In this study we addressed the question whether patients with unmedicated major depressive disorder (MDD) might have altered baseline levels of these natriuretic peptides and an altered response to acute exercise. METHODS: An incremental exercise test was performed in 18 patients with MDD and in 18 healthy controls. Plasma concentrations of ANP and BNP were determined at rest, during the exercise test and 30min post exercise using immunoradiometric assays. RESULTS: During the exercise test the concentrations of ANP and BNP increased significantly in both groups. The MDD group showed significantly lower levels of ANP than the controls at rest, at maximal work rate and post exercise and of BNP at rest and at maximal work rate. The dynamic changes of both ANP and BNP, respectively, from baseline to maximal work rate were significantly lower in the MDD group. A slightly lower (non-significant) maximal work rate was observed in the MDD group compared with the controls. LIMITATIONS: Group sizes are relatively limited. CONCLUSION: Lower concentrations of ANP and BNP during rest and exercise were observed in the MDD patients together with a decreased dynamic response to maximal exercise. Hypothetically, the reduced ANP and BNP concentration contributes to the high hormone levels in the HPA system seen in depressive disorders. Of interest for future research is whether physical training might increase the levels of ANP and BNP and thereby diminish depressive symptoms.},
  author       = {Wisén, Anita and Ekberg, Kristina and Wohlfart, Björn and Ekman, Rolf and Westrin, Åsa},
  issn         = {1573-2517},
  language     = {eng},
  number       = {1-3},
  pages        = {371--375},
  publisher    = {Elsevier},
  series       = {Journal of Affective Disorders},
  title        = {Plasma ANP and BNP during exercise in patients with major depressive disorder and in healthy controls.},
  url          = {http://dx.doi.org/10.1016/j.jad.2010.09.002},
  doi          = {10.1016/j.jad.2010.09.002},
  volume       = {129},
  year         = {2011},
}