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Pathophysiology of typical hemolytic uremic syndrome.

Karpman, Diana LU ; Sartz, Lisa LU and Johnson, Sally (2010) In Seminars in Thrombosis and Hemostasis 36(6). p.575-585
Abstract
The typical form of hemolytic uremic syndrome (HUS) is associated with enterohemorrhagic ESCHERICHIA COLI (EHEC) infection. The disease process is initiated and perpetuated by interactions between the pathogen or its virulence factors and host cells, as well as the host response. During EHEC-associated HUS, alterations occurring at the intestinal mucosal barrier and in the circulation, as well as on endothelial cells and other target-organ cells, lead to cell activation and/or cytotoxicity, and trigger a prothrombotic state. This review summarizes current knowledge regarding the interactions of the pathogen and its virulence factors with cells in the intestine, bloodstream, kidney, and brain. Mechanisms of bacterial colonization, toxin... (More)
The typical form of hemolytic uremic syndrome (HUS) is associated with enterohemorrhagic ESCHERICHIA COLI (EHEC) infection. The disease process is initiated and perpetuated by interactions between the pathogen or its virulence factors and host cells, as well as the host response. During EHEC-associated HUS, alterations occurring at the intestinal mucosal barrier and in the circulation, as well as on endothelial cells and other target-organ cells, lead to cell activation and/or cytotoxicity, and trigger a prothrombotic state. This review summarizes current knowledge regarding the interactions of the pathogen and its virulence factors with cells in the intestine, bloodstream, kidney, and brain. Mechanisms of bacterial colonization, toxin circulation, and induction of target organ damage are discussed. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Seminars in Thrombosis and Hemostasis
volume
36
issue
6
pages
575 - 585
publisher
Georg Thieme Verlag
external identifiers
  • pmid:20865634
  • wos:000281403200003
  • scopus:77957588040
ISSN
1098-9064
DOI
10.1055/s-0030-1262879
language
English
LU publication?
yes
id
27478549-c50d-4e6a-a80d-86288d7c9cdb (old id 1687897)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20865634?dopt=Abstract
date added to LUP
2010-10-07 16:30:29
date last changed
2018-05-29 09:43:46
@article{27478549-c50d-4e6a-a80d-86288d7c9cdb,
  abstract     = {The typical form of hemolytic uremic syndrome (HUS) is associated with enterohemorrhagic ESCHERICHIA COLI (EHEC) infection. The disease process is initiated and perpetuated by interactions between the pathogen or its virulence factors and host cells, as well as the host response. During EHEC-associated HUS, alterations occurring at the intestinal mucosal barrier and in the circulation, as well as on endothelial cells and other target-organ cells, lead to cell activation and/or cytotoxicity, and trigger a prothrombotic state. This review summarizes current knowledge regarding the interactions of the pathogen and its virulence factors with cells in the intestine, bloodstream, kidney, and brain. Mechanisms of bacterial colonization, toxin circulation, and induction of target organ damage are discussed.},
  author       = {Karpman, Diana and Sartz, Lisa and Johnson, Sally},
  issn         = {1098-9064},
  language     = {eng},
  number       = {6},
  pages        = {575--585},
  publisher    = {Georg Thieme Verlag},
  series       = {Seminars in Thrombosis and Hemostasis},
  title        = {Pathophysiology of typical hemolytic uremic syndrome.},
  url          = {http://dx.doi.org/10.1055/s-0030-1262879},
  volume       = {36},
  year         = {2010},
}