Pathophysiology of typical hemolytic uremic syndrome.
Karpman, Diana LU
; Sartz, Lisa
LU
and Johnson, Sally
(2010)
In Seminars in Thrombosis and Hemostasis
36(6).
p.575-585
- Abstract
- The typical form of hemolytic uremic syndrome (HUS) is associated with enterohemorrhagic ESCHERICHIA COLI (EHEC) infection. The disease process is initiated and perpetuated by interactions between the pathogen or its virulence factors and host cells, as well as the host response. During EHEC-associated HUS, alterations occurring at the intestinal mucosal barrier and in the circulation, as well as on endothelial cells and other target-organ cells, lead to cell activation and/or cytotoxicity, and trigger a prothrombotic state. This review summarizes current knowledge regarding the interactions of the pathogen and its virulence factors with cells in the intestine, bloodstream, kidney, and brain. Mechanisms of bacterial colonization, toxin... (More)
- The typical form of hemolytic uremic syndrome (HUS) is associated with enterohemorrhagic ESCHERICHIA COLI (EHEC) infection. The disease process is initiated and perpetuated by interactions between the pathogen or its virulence factors and host cells, as well as the host response. During EHEC-associated HUS, alterations occurring at the intestinal mucosal barrier and in the circulation, as well as on endothelial cells and other target-organ cells, lead to cell activation and/or cytotoxicity, and trigger a prothrombotic state. This review summarizes current knowledge regarding the interactions of the pathogen and its virulence factors with cells in the intestine, bloodstream, kidney, and brain. Mechanisms of bacterial colonization, toxin circulation, and induction of target organ damage are discussed. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1687897
- author
- Karpman, Diana
LU
; Sartz, Lisa
LU
and Johnson, Sally
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Seminars in Thrombosis and Hemostasis
- volume
- 36
- issue
- 6
- pages
- 575 - 585
- publisher
- Georg Thieme Verlag
- external identifiers
-
- pmid:20865634
- wos:000281403200003
- scopus:77957588040
- ISSN
- 1098-9064
- DOI
- 10.1055/s-0030-1262879
- language
- English
- LU publication?
- yes
- id
- 27478549-c50d-4e6a-a80d-86288d7c9cdb (old id 1687897)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20865634?dopt=Abstract
- date added to LUP
- 2016-04-01 10:25:46
- date last changed
- 2022-01-25 23:03:55
@article{27478549-c50d-4e6a-a80d-86288d7c9cdb,
abstract = {{The typical form of hemolytic uremic syndrome (HUS) is associated with enterohemorrhagic ESCHERICHIA COLI (EHEC) infection. The disease process is initiated and perpetuated by interactions between the pathogen or its virulence factors and host cells, as well as the host response. During EHEC-associated HUS, alterations occurring at the intestinal mucosal barrier and in the circulation, as well as on endothelial cells and other target-organ cells, lead to cell activation and/or cytotoxicity, and trigger a prothrombotic state. This review summarizes current knowledge regarding the interactions of the pathogen and its virulence factors with cells in the intestine, bloodstream, kidney, and brain. Mechanisms of bacterial colonization, toxin circulation, and induction of target organ damage are discussed.}},
author = {{Karpman, Diana and Sartz, Lisa and Johnson, Sally}},
issn = {{1098-9064}},
language = {{eng}},
number = {{6}},
pages = {{575--585}},
publisher = {{Georg Thieme Verlag}},
series = {{Seminars in Thrombosis and Hemostasis}},
title = {{Pathophysiology of typical hemolytic uremic syndrome.}},
url = {{https://lup.lub.lu.se/search/files/1839529/1711762.pdf}},
doi = {{10.1055/s-0030-1262879}},
volume = {{36}},
year = {{2010}},
}