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Abnormal atrial activation in young patients with lone atrial fibrillation.

Holmqvist, Fredrik LU ; Olesen, Morten S; Tveit, Arnljot; Enger, Steve; Tapanainen, Jari; Jurkko, Raija; Havmöller, Rasmus LU ; Haunsø, Stig; Carlson, Jonas LU and Svendsen, Jesper H, et al. (2011) In Europace Okt. p.188-192
Abstract
Aims Patients with a history of atrial fibrillation (AF) have previously been shown to have altered atrial conduction, as seen non-invasively using signal-averaged P-wave analysis. However, little is known about the P-wave morphology in patients in the early phases of AF with structurally normal hearts. Methods and results Thirty-six patients with lone AF were included before the age of 40 years (34 ± 4 years, 34 men) and compared with age- and gender-matched control subjects. Standard 12-lead electrocardiogram (ECG) was recorded for at least 10 s. P-wave morphology and duration were estimated using signal-averaged P-wave analysis. Echocardiography was performed in association with the ECG recording. Heart rate (67 ± 13 vs. 65 ± 7 b.p.m.,... (More)
Aims Patients with a history of atrial fibrillation (AF) have previously been shown to have altered atrial conduction, as seen non-invasively using signal-averaged P-wave analysis. However, little is known about the P-wave morphology in patients in the early phases of AF with structurally normal hearts. Methods and results Thirty-six patients with lone AF were included before the age of 40 years (34 ± 4 years, 34 men) and compared with age- and gender-matched control subjects. Standard 12-lead electrocardiogram (ECG) was recorded for at least 10 s. P-wave morphology and duration were estimated using signal-averaged P-wave analysis. Echocardiography was performed in association with the ECG recording. Heart rate (67 ± 13 vs. 65 ± 7 b.p.m., P = 0.800) and PQ-interval (163 ± 16 vs. 164 ± 23 ms, P = 0.629) were similar in AF cases and controls, as was P-wave duration (136 ± 13 vs. 129 ± 13 ms, P = 0.107). The distribution of P-wave morphology differed between the AF cases and controls [33/58/0/8 vs. 75/25/0/0% (Type 1/Type 2/Type 3/atypical), P = 0.001], with a larger proportion of patients with AF exhibiting signs of impaired interatrial conduction. Conclusion A significant difference in P-wave morphology distribution was seen between patients with early-onset, lone paroxysmal AF and age- and gender-matched healthy control subjects. This finding indicates that alterations in atrial electrophysiology are common in the early stage of the arrhythmia, and since it occurs in young patients without co-morbidity may well be the cause rather than the consequence of AF. (Less)
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Europace
volume
Okt
pages
188 - 192
publisher
Oxford University Press
external identifiers
  • wos:000286466400010
  • pmid:20864492
  • scopus:79251505301
ISSN
1532-2092
DOI
10.1093/europace/euq352
language
English
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yes
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54f53a4d-083e-4df9-ab95-b3a24a887691 (old id 1687916)
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http://www.ncbi.nlm.nih.gov/pubmed/20864492?dopt=Abstract
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2010-10-06 08:22:27
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2017-10-08 04:28:23
@article{54f53a4d-083e-4df9-ab95-b3a24a887691,
  abstract     = {Aims Patients with a history of atrial fibrillation (AF) have previously been shown to have altered atrial conduction, as seen non-invasively using signal-averaged P-wave analysis. However, little is known about the P-wave morphology in patients in the early phases of AF with structurally normal hearts. Methods and results Thirty-six patients with lone AF were included before the age of 40 years (34 ± 4 years, 34 men) and compared with age- and gender-matched control subjects. Standard 12-lead electrocardiogram (ECG) was recorded for at least 10 s. P-wave morphology and duration were estimated using signal-averaged P-wave analysis. Echocardiography was performed in association with the ECG recording. Heart rate (67 ± 13 vs. 65 ± 7 b.p.m., P = 0.800) and PQ-interval (163 ± 16 vs. 164 ± 23 ms, P = 0.629) were similar in AF cases and controls, as was P-wave duration (136 ± 13 vs. 129 ± 13 ms, P = 0.107). The distribution of P-wave morphology differed between the AF cases and controls [33/58/0/8 vs. 75/25/0/0% (Type 1/Type 2/Type 3/atypical), P = 0.001], with a larger proportion of patients with AF exhibiting signs of impaired interatrial conduction. Conclusion A significant difference in P-wave morphology distribution was seen between patients with early-onset, lone paroxysmal AF and age- and gender-matched healthy control subjects. This finding indicates that alterations in atrial electrophysiology are common in the early stage of the arrhythmia, and since it occurs in young patients without co-morbidity may well be the cause rather than the consequence of AF.},
  author       = {Holmqvist, Fredrik and Olesen, Morten S and Tveit, Arnljot and Enger, Steve and Tapanainen, Jari and Jurkko, Raija and Havmöller, Rasmus and Haunsø, Stig and Carlson, Jonas and Svendsen, Jesper H and Platonov, Pyotr},
  issn         = {1532-2092},
  language     = {eng},
  pages        = {188--192},
  publisher    = {Oxford University Press},
  series       = {Europace},
  title        = {Abnormal atrial activation in young patients with lone atrial fibrillation.},
  url          = {http://dx.doi.org/10.1093/europace/euq352},
  volume       = {Okt},
  year         = {2011},
}