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Current approaches to measuring human islet-antigen specific T cell function in type 1 diabetes.

Mannering, S I; Wong, F S; Durinovic-Belló, I; Brooks-Worrell, B; Tree, T I; Cilio, Corrado LU ; Schloot, N C and Mallone, R (2010) In Clinical and Experimental Immunology okt. p.197-209
Abstract
Type 1 diabetes (T1D) is an autoimmune disease caused by the T cell-mediated destruction of the pancreatic insulin-producing beta cells. Currently there are no widely accepted and standardized assays available to analyse the function of autoreactive T cells involved in T1D. The development of such an assay would greatly aid efforts to understand the pathogenesis of T1D and is also urgently required to guide the development of antigen-based therapies intended to prevent, or cure, T1D. Here we describe some of the assays used currently to detect autoreactive T cells in human blood and review critically their strengths and weaknesses. The challenges and future prospects for the T cell assays are discussed.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical and Experimental Immunology
volume
okt
pages
197 - 209
publisher
British Society for Immunology
external identifiers
  • wos:000282694800001
  • pmid:20846160
  • scopus:78649358914
ISSN
0009-9104
DOI
10.1111/j.1365-2249.2010.04237.x
language
English
LU publication?
yes
id
bab634ab-27c0-40be-a5e7-d972fb55936a (old id 1688166)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20846160?dopt=Abstract
date added to LUP
2010-10-05 10:05:03
date last changed
2018-05-29 12:07:06
@article{bab634ab-27c0-40be-a5e7-d972fb55936a,
  abstract     = {Type 1 diabetes (T1D) is an autoimmune disease caused by the T cell-mediated destruction of the pancreatic insulin-producing beta cells. Currently there are no widely accepted and standardized assays available to analyse the function of autoreactive T cells involved in T1D. The development of such an assay would greatly aid efforts to understand the pathogenesis of T1D and is also urgently required to guide the development of antigen-based therapies intended to prevent, or cure, T1D. Here we describe some of the assays used currently to detect autoreactive T cells in human blood and review critically their strengths and weaknesses. The challenges and future prospects for the T cell assays are discussed.},
  author       = {Mannering, S I and Wong, F S and Durinovic-Belló, I and Brooks-Worrell, B and Tree, T I and Cilio, Corrado and Schloot, N C and Mallone, R},
  issn         = {0009-9104},
  language     = {eng},
  pages        = {197--209},
  publisher    = {British Society for Immunology},
  series       = {Clinical and Experimental Immunology},
  title        = {Current approaches to measuring human islet-antigen specific T cell function in type 1 diabetes.},
  url          = {http://dx.doi.org/10.1111/j.1365-2249.2010.04237.x},
  volume       = {okt},
  year         = {2010},
}