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Genetic profiles distinguish different types of hereditary ovarian cancer.

Bartuma, Katarina LU ; Malander, Susanne LU ; Staaf, Johan LU ; Karlsson, Anna F LU ; Borg, Åke LU ; Jönsson, Göran B LU and Nilbert, Mef LU (2010) In Oncology Reports 24(4). p.885-895
Abstract
Heredity represents the strongest risk factor for ovarian cancer with disease predisposing mutations identified in 15% of the tumors. With the aim to identify genetic classifiers for hereditary ovarian cancer, we profiled hereditary ovarian cancers linked to the hereditary breast and ovarian cancer (HBOC) syndrome and the hereditary non-polyposis colorectal cancer (HNPCC) syndrome. Genome-wide array comparative genomic hybridization was applied to 12 HBOC associated tumors with BRCA1 mutations and 8 HNPCC associated tumors with mismatch repair gene mutations with 24 sporadic ovarian cancers as a control group. Unsupervised cluster analysis identified two distinct subgroups related to genetic complexity. Sporadic and HBOC associated tumors... (More)
Heredity represents the strongest risk factor for ovarian cancer with disease predisposing mutations identified in 15% of the tumors. With the aim to identify genetic classifiers for hereditary ovarian cancer, we profiled hereditary ovarian cancers linked to the hereditary breast and ovarian cancer (HBOC) syndrome and the hereditary non-polyposis colorectal cancer (HNPCC) syndrome. Genome-wide array comparative genomic hybridization was applied to 12 HBOC associated tumors with BRCA1 mutations and 8 HNPCC associated tumors with mismatch repair gene mutations with 24 sporadic ovarian cancers as a control group. Unsupervised cluster analysis identified two distinct subgroups related to genetic complexity. Sporadic and HBOC associated tumors had complex genetic profiles with an average 41% of the genome altered, whereas the mismatch repair defective tumors had stable genetic profiles, with an average 18% of the genome altered. Losses of 4q34, 13q12-q32 and 19p13 were overrepresented in the HBOC subset. Discriminating genes within these regions include BRCA2, FOXO1A and RB1. Gains on chromosomes 17 and 19 characterized the HNPCC tumors, but target genes herein are unknown. The results indicate that HBOC and HNPCC associated ovarian cancer develop along distinct genetic pathways and genetic profiles can thus be applied to distinguish between different types of hereditary ovarian cancer. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Oncology Reports
volume
24
issue
4
pages
885 - 895
publisher
D.A. Spandidos
external identifiers
  • wos:000281992400010
  • pmid:20811668
  • scopus:77957377822
ISSN
1791-2431
DOI
10.3892/or_00000934
language
English
LU publication?
yes
id
37f9cb2e-0c4d-43b3-81ff-50abc4139292 (old id 1688600)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20811668?dopt=Abstract
date added to LUP
2010-10-03 19:53:50
date last changed
2017-01-01 07:43:57
@article{37f9cb2e-0c4d-43b3-81ff-50abc4139292,
  abstract     = {Heredity represents the strongest risk factor for ovarian cancer with disease predisposing mutations identified in 15% of the tumors. With the aim to identify genetic classifiers for hereditary ovarian cancer, we profiled hereditary ovarian cancers linked to the hereditary breast and ovarian cancer (HBOC) syndrome and the hereditary non-polyposis colorectal cancer (HNPCC) syndrome. Genome-wide array comparative genomic hybridization was applied to 12 HBOC associated tumors with BRCA1 mutations and 8 HNPCC associated tumors with mismatch repair gene mutations with 24 sporadic ovarian cancers as a control group. Unsupervised cluster analysis identified two distinct subgroups related to genetic complexity. Sporadic and HBOC associated tumors had complex genetic profiles with an average 41% of the genome altered, whereas the mismatch repair defective tumors had stable genetic profiles, with an average 18% of the genome altered. Losses of 4q34, 13q12-q32 and 19p13 were overrepresented in the HBOC subset. Discriminating genes within these regions include BRCA2, FOXO1A and RB1. Gains on chromosomes 17 and 19 characterized the HNPCC tumors, but target genes herein are unknown. The results indicate that HBOC and HNPCC associated ovarian cancer develop along distinct genetic pathways and genetic profiles can thus be applied to distinguish between different types of hereditary ovarian cancer.},
  author       = {Bartuma, Katarina and Malander, Susanne and Staaf, Johan and Karlsson, Anna F and Borg, Åke and Jönsson, Göran B and Nilbert, Mef},
  issn         = {1791-2431},
  language     = {eng},
  number       = {4},
  pages        = {885--895},
  publisher    = {D.A. Spandidos},
  series       = {Oncology Reports},
  title        = {Genetic profiles distinguish different types of hereditary ovarian cancer.},
  url          = {http://dx.doi.org/10.3892/or_00000934},
  volume       = {24},
  year         = {2010},
}