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Associations between the angiotensin-converting enzyme insertion/deletion polymorphism and monoamine metabolite concentrations in cerebrospinal fluid

Annerbrink, Kristina; Jonsson, Erik G.; Olsson, Marie; Nilsson, Staffan; Sedvall, Goran C.; Anckarsäter, Henrik LU and Eriksson, Elias (2010) In Psychiatry Research 179(2). p.231-234
Abstract
Angiotensin II has been suggested to influence central dopamine and serotonin turnover. Since the angiotensin-converting enzyme (ACE) plays a key role in angiotensin regulation by converting inactive angiotensin 1 to active angiotensin II, we hypothesised that the functional insertion/deletion (I/D) polymorphism in the ACE gene, which has previously been suggested to be associated with, depression and panic disorder, may influence monoamine activity. A well-established technique for assessing brain monoamine turnover in humans is to measure concentrations of monoamine metabolites in the cerebrospinal fluid (CSF). We thus investigated possible associations between the ACE I/D polymorphism and CSF monoamine metabolite concentrations in a... (More)
Angiotensin II has been suggested to influence central dopamine and serotonin turnover. Since the angiotensin-converting enzyme (ACE) plays a key role in angiotensin regulation by converting inactive angiotensin 1 to active angiotensin II, we hypothesised that the functional insertion/deletion (I/D) polymorphism in the ACE gene, which has previously been suggested to be associated with, depression and panic disorder, may influence monoamine activity. A well-established technique for assessing brain monoamine turnover in humans is to measure concentrations of monoamine metabolites in the cerebrospinal fluid (CSF). We thus investigated possible associations between the ACE I/D polymorphism and CSF monoamine metabolite concentrations in a population of healthy male subjects. After having found such an association between the ACE I/D polymorphism and CSF levels of the dopamine metabolite homovanillic acid and the serotonin metabolite 5-hydroxyindoleacetic acid in this sample, I carriers displaying lower levels, we tried to replicate this observation in a population of violent male offenders from which also both CSF and DNA were available. Also in this sample, the same associations were found. Our results suggest that the ACE I/D polymorphism may play a role in the modulation of serotonergic and dopaminergic turnover in men. (C) 2009 Elsevier Ireland Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
HVA, Dopamine, 5-HIAA, Serotonin, Angiotensin, ACE I/D
in
Psychiatry Research
volume
179
issue
2
pages
231 - 234
publisher
Elsevier
external identifiers
  • wos:000282388200020
  • scopus:77956181894
ISSN
1872-7123
DOI
10.1016/j.psychres.2009.04.018
language
English
LU publication?
yes
id
3737eefc-3679-4452-9e96-9e1eb59a3b0b (old id 1694123)
date added to LUP
2010-10-27 14:01:40
date last changed
2018-06-17 03:12:04
@article{3737eefc-3679-4452-9e96-9e1eb59a3b0b,
  abstract     = {Angiotensin II has been suggested to influence central dopamine and serotonin turnover. Since the angiotensin-converting enzyme (ACE) plays a key role in angiotensin regulation by converting inactive angiotensin 1 to active angiotensin II, we hypothesised that the functional insertion/deletion (I/D) polymorphism in the ACE gene, which has previously been suggested to be associated with, depression and panic disorder, may influence monoamine activity. A well-established technique for assessing brain monoamine turnover in humans is to measure concentrations of monoamine metabolites in the cerebrospinal fluid (CSF). We thus investigated possible associations between the ACE I/D polymorphism and CSF monoamine metabolite concentrations in a population of healthy male subjects. After having found such an association between the ACE I/D polymorphism and CSF levels of the dopamine metabolite homovanillic acid and the serotonin metabolite 5-hydroxyindoleacetic acid in this sample, I carriers displaying lower levels, we tried to replicate this observation in a population of violent male offenders from which also both CSF and DNA were available. Also in this sample, the same associations were found. Our results suggest that the ACE I/D polymorphism may play a role in the modulation of serotonergic and dopaminergic turnover in men. (C) 2009 Elsevier Ireland Ltd. All rights reserved.},
  author       = {Annerbrink, Kristina and Jonsson, Erik G. and Olsson, Marie and Nilsson, Staffan and Sedvall, Goran C. and Anckarsäter, Henrik and Eriksson, Elias},
  issn         = {1872-7123},
  keyword      = {HVA,Dopamine,5-HIAA,Serotonin,Angiotensin,ACE I/D},
  language     = {eng},
  number       = {2},
  pages        = {231--234},
  publisher    = {Elsevier},
  series       = {Psychiatry Research},
  title        = {Associations between the angiotensin-converting enzyme insertion/deletion polymorphism and monoamine metabolite concentrations in cerebrospinal fluid},
  url          = {http://dx.doi.org/10.1016/j.psychres.2009.04.018},
  volume       = {179},
  year         = {2010},
}