Associations between the angiotensin-converting enzyme insertion/deletion polymorphism and monoamine metabolite concentrations in cerebrospinal fluid
(2010) In Psychiatry Research 179(2). p.231-234- Abstract
- Angiotensin II has been suggested to influence central dopamine and serotonin turnover. Since the angiotensin-converting enzyme (ACE) plays a key role in angiotensin regulation by converting inactive angiotensin 1 to active angiotensin II, we hypothesised that the functional insertion/deletion (I/D) polymorphism in the ACE gene, which has previously been suggested to be associated with, depression and panic disorder, may influence monoamine activity. A well-established technique for assessing brain monoamine turnover in humans is to measure concentrations of monoamine metabolites in the cerebrospinal fluid (CSF). We thus investigated possible associations between the ACE I/D polymorphism and CSF monoamine metabolite concentrations in a... (More)
- Angiotensin II has been suggested to influence central dopamine and serotonin turnover. Since the angiotensin-converting enzyme (ACE) plays a key role in angiotensin regulation by converting inactive angiotensin 1 to active angiotensin II, we hypothesised that the functional insertion/deletion (I/D) polymorphism in the ACE gene, which has previously been suggested to be associated with, depression and panic disorder, may influence monoamine activity. A well-established technique for assessing brain monoamine turnover in humans is to measure concentrations of monoamine metabolites in the cerebrospinal fluid (CSF). We thus investigated possible associations between the ACE I/D polymorphism and CSF monoamine metabolite concentrations in a population of healthy male subjects. After having found such an association between the ACE I/D polymorphism and CSF levels of the dopamine metabolite homovanillic acid and the serotonin metabolite 5-hydroxyindoleacetic acid in this sample, I carriers displaying lower levels, we tried to replicate this observation in a population of violent male offenders from which also both CSF and DNA were available. Also in this sample, the same associations were found. Our results suggest that the ACE I/D polymorphism may play a role in the modulation of serotonergic and dopaminergic turnover in men. (C) 2009 Elsevier Ireland Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1694123
- author
- Annerbrink, Kristina ; Jonsson, Erik G. ; Olsson, Marie ; Nilsson, Staffan ; Sedvall, Goran C. ; Anckarsäter, Henrik LU and Eriksson, Elias
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- HVA, Dopamine, 5-HIAA, Serotonin, Angiotensin, ACE I/D
- in
- Psychiatry Research
- volume
- 179
- issue
- 2
- pages
- 231 - 234
- publisher
- Elsevier
- external identifiers
-
- wos:000282388200020
- scopus:77956181894
- ISSN
- 1872-7123
- DOI
- 10.1016/j.psychres.2009.04.018
- language
- English
- LU publication?
- yes
- id
- 3737eefc-3679-4452-9e96-9e1eb59a3b0b (old id 1694123)
- date added to LUP
- 2016-04-01 10:10:08
- date last changed
- 2022-04-27 19:15:44
@article{3737eefc-3679-4452-9e96-9e1eb59a3b0b,
abstract = {{Angiotensin II has been suggested to influence central dopamine and serotonin turnover. Since the angiotensin-converting enzyme (ACE) plays a key role in angiotensin regulation by converting inactive angiotensin 1 to active angiotensin II, we hypothesised that the functional insertion/deletion (I/D) polymorphism in the ACE gene, which has previously been suggested to be associated with, depression and panic disorder, may influence monoamine activity. A well-established technique for assessing brain monoamine turnover in humans is to measure concentrations of monoamine metabolites in the cerebrospinal fluid (CSF). We thus investigated possible associations between the ACE I/D polymorphism and CSF monoamine metabolite concentrations in a population of healthy male subjects. After having found such an association between the ACE I/D polymorphism and CSF levels of the dopamine metabolite homovanillic acid and the serotonin metabolite 5-hydroxyindoleacetic acid in this sample, I carriers displaying lower levels, we tried to replicate this observation in a population of violent male offenders from which also both CSF and DNA were available. Also in this sample, the same associations were found. Our results suggest that the ACE I/D polymorphism may play a role in the modulation of serotonergic and dopaminergic turnover in men. (C) 2009 Elsevier Ireland Ltd. All rights reserved.}},
author = {{Annerbrink, Kristina and Jonsson, Erik G. and Olsson, Marie and Nilsson, Staffan and Sedvall, Goran C. and Anckarsäter, Henrik and Eriksson, Elias}},
issn = {{1872-7123}},
keywords = {{HVA; Dopamine; 5-HIAA; Serotonin; Angiotensin; ACE I/D}},
language = {{eng}},
number = {{2}},
pages = {{231--234}},
publisher = {{Elsevier}},
series = {{Psychiatry Research}},
title = {{Associations between the angiotensin-converting enzyme insertion/deletion polymorphism and monoamine metabolite concentrations in cerebrospinal fluid}},
url = {{http://dx.doi.org/10.1016/j.psychres.2009.04.018}},
doi = {{10.1016/j.psychres.2009.04.018}},
volume = {{179}},
year = {{2010}},
}