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Antibody response to IgA-binding streptococcal M proteins in children with IgA nephropathy

Schmitt, Roland LU ; Lindahl, Gunnar LU and Karpman, Diana LU (2010) In Nephrology Dialysis Transplantation 25(10). p.3434-3436
Abstract
Methods. Blood samples from patients with IgAN (n = 21) and age-matched controls (n = 83) were assayed by ELISA to detect an IgG antibody response to the IgA-BRs of the M4, M22 and M60 proteins. Antibodies were assayed for each IgA-BR separately and the results were combined. Results. Antibody levels to the IgA-BRs were significantly higher in IgAN patients than controls (P = 0.016), particularly in patients with recent streptococcal infection (P = 0.008). Conclusions. The results suggest that children with IgAN had a previous infection with a streptococcal strain expressing an IgA-binding M protein.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
IgA nephropathy, children, group A streptococci, M protein
in
Nephrology Dialysis Transplantation
volume
25
issue
10
pages
3434 - 3436
publisher
Oxford University Press
external identifiers
  • wos:000282172300048
  • scopus:77957225927
ISSN
1460-2385
DOI
10.1093/ndt/gfq346
language
English
LU publication?
yes
id
a19fdac0-485e-4623-97df-72a9aa15c329 (old id 1694587)
date added to LUP
2010-10-26 11:32:34
date last changed
2018-05-29 10:21:39
@article{a19fdac0-485e-4623-97df-72a9aa15c329,
  abstract     = {Methods. Blood samples from patients with IgAN (n = 21) and age-matched controls (n = 83) were assayed by ELISA to detect an IgG antibody response to the IgA-BRs of the M4, M22 and M60 proteins. Antibodies were assayed for each IgA-BR separately and the results were combined. Results. Antibody levels to the IgA-BRs were significantly higher in IgAN patients than controls (P = 0.016), particularly in patients with recent streptococcal infection (P = 0.008). Conclusions. The results suggest that children with IgAN had a previous infection with a streptococcal strain expressing an IgA-binding M protein.},
  author       = {Schmitt, Roland and Lindahl, Gunnar and Karpman, Diana},
  issn         = {1460-2385},
  keyword      = {IgA nephropathy,children,group A streptococci,M protein},
  language     = {eng},
  number       = {10},
  pages        = {3434--3436},
  publisher    = {Oxford University Press},
  series       = {Nephrology Dialysis Transplantation},
  title        = {Antibody response to IgA-binding streptococcal M proteins in children with IgA nephropathy},
  url          = {http://dx.doi.org/10.1093/ndt/gfq346},
  volume       = {25},
  year         = {2010},
}