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Variety in Fruit and Vegetable Consumption and the Risk of Lung Cancer in the European Prospective Investigation into Cancer and Nutrition

Buchner, Frederike L.; Bueno-de-Mesquita, H. Bas; Ros, Martine M.; Overvad, Kim; Dahm, Christina C.; Hansen, Louise; Tjonneland, Anne; Clavel-Chapelon, Francoise; Boutron-Ruault, Marie-Christine and Touillaud, Marina, et al. (2010) In Cancer Epidemiology Biomarkers & Prevention 19(9). p.2278-2286
Abstract
Background: We investigated whether a varied consumption of vegetables and fruits is associated with lower lung cancer risk in the European Prospective Investigation into Cancer and Nutrition study. Methods: After a mean follow-up of 8.7 years, 1,613 of 452,187 participants with complete information were diagnosed with lung cancer. Diet diversity scores (DDS) were used to quantify the variety in fruit and vegetable consumption. Multivariable proportional hazards models were used to assess the associations between DDS and lung cancer risk. All models were adjusted for smoking behavior and the total consumption of fruit and vegetables. Results: With increasing variety in vegetable subgroups, risk of lung cancer decreases [hazard ratios (HR),... (More)
Background: We investigated whether a varied consumption of vegetables and fruits is associated with lower lung cancer risk in the European Prospective Investigation into Cancer and Nutrition study. Methods: After a mean follow-up of 8.7 years, 1,613 of 452,187 participants with complete information were diagnosed with lung cancer. Diet diversity scores (DDS) were used to quantify the variety in fruit and vegetable consumption. Multivariable proportional hazards models were used to assess the associations between DDS and lung cancer risk. All models were adjusted for smoking behavior and the total consumption of fruit and vegetables. Results: With increasing variety in vegetable subgroups, risk of lung cancer decreases [hazard ratios (HR), 0.77; 95% confidence interval (CI), 0.64-0.94 highest versus lowest quartile; P trend = 0.02]. This inverse association is restricted to current smokers (HR, 0.73; 95% CI, 0.57-0.93 highest versus lowest quartile; P trend = 0.03). In continuous analyses, in current smokers, lower risks were observed for squamous cell carcinomas with more variety in fruit and vegetable products combined (HR/two products, 0.88; 95% CI, 0.82-0.95), vegetable subgroups (HR/subgroup, 0.88; 95% CI, 0.79-0.97), vegetable products (HR/two products, 0.87; 95% CI, 0.79-0.96), and fruit products (HR/two products, 0.84; 95% CI, 0.72-0.97). Conclusion: Variety in vegetable consumption was inversely associated with lung cancer risk among current smokers. Risk of squamous cell carcinomas was reduced with increasing variety in fruit and/or vegetable consumption, which was mainly driven by the effect in current smokers. Impact: Independent from quantity of consumption, variety in fruit and vegetable consumption may decrease lung cancer risk. Cancer Epidemiol Biomarkers Prev; 19(9); 2278-86. (C) 2010 AACR. (Less)
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published
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Cancer Epidemiology Biomarkers & Prevention
volume
19
issue
9
pages
2278 - 2286
publisher
American Association for Cancer Research
external identifiers
  • wos:000281683800018
  • scopus:77956544812
ISSN
1538-7755
DOI
10.1158/1055-9965.EPI-10-0489
language
English
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yes
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9a8d7a06-be8f-4244-a72f-fa7eadb51b23 (old id 1697476)
date added to LUP
2010-10-25 10:04:05
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2018-07-08 03:40:35
@article{9a8d7a06-be8f-4244-a72f-fa7eadb51b23,
  abstract     = {Background: We investigated whether a varied consumption of vegetables and fruits is associated with lower lung cancer risk in the European Prospective Investigation into Cancer and Nutrition study. Methods: After a mean follow-up of 8.7 years, 1,613 of 452,187 participants with complete information were diagnosed with lung cancer. Diet diversity scores (DDS) were used to quantify the variety in fruit and vegetable consumption. Multivariable proportional hazards models were used to assess the associations between DDS and lung cancer risk. All models were adjusted for smoking behavior and the total consumption of fruit and vegetables. Results: With increasing variety in vegetable subgroups, risk of lung cancer decreases [hazard ratios (HR), 0.77; 95% confidence interval (CI), 0.64-0.94 highest versus lowest quartile; P trend = 0.02]. This inverse association is restricted to current smokers (HR, 0.73; 95% CI, 0.57-0.93 highest versus lowest quartile; P trend = 0.03). In continuous analyses, in current smokers, lower risks were observed for squamous cell carcinomas with more variety in fruit and vegetable products combined (HR/two products, 0.88; 95% CI, 0.82-0.95), vegetable subgroups (HR/subgroup, 0.88; 95% CI, 0.79-0.97), vegetable products (HR/two products, 0.87; 95% CI, 0.79-0.96), and fruit products (HR/two products, 0.84; 95% CI, 0.72-0.97). Conclusion: Variety in vegetable consumption was inversely associated with lung cancer risk among current smokers. Risk of squamous cell carcinomas was reduced with increasing variety in fruit and/or vegetable consumption, which was mainly driven by the effect in current smokers. Impact: Independent from quantity of consumption, variety in fruit and vegetable consumption may decrease lung cancer risk. Cancer Epidemiol Biomarkers Prev; 19(9); 2278-86. (C) 2010 AACR.},
  author       = {Buchner, Frederike L. and Bueno-de-Mesquita, H. Bas and Ros, Martine M. and Overvad, Kim and Dahm, Christina C. and Hansen, Louise and Tjonneland, Anne and Clavel-Chapelon, Francoise and Boutron-Ruault, Marie-Christine and Touillaud, Marina and Kaaks, Rudolf and Rohrmann, Sabine and Boeing, Heiner and Noethlings, Ute and Trichopoulou, Antonia and Zylis, Dimosthenis and Dilis, Vardis and Palli, Domenico and Sieri, Sabina and Vineis, Paolo and Tumino, Rosario and Panico, Salvatore and Peeters, Petra H. M. and van Gils, Carla H. and Lund, Eiliv and Gram, Inger T. and Braaten, Tonje and Sanchez, Maria-Jose and Agudo, Antonio and Larranaga, Nerea and Ardanaz, Eva and Navarro, Carmen and Argueelles, Marcial V. and Manjer, Jonas and Wirfält, Elisabet and Hallmans, Goeran and Rasmuson, Torgny and Key, Tim J. and Khaw, Kay-Tee and Wareham, Nick and Silimani, Nadia and Vergnaud, Anne-Claire and Xun, Wei W. and Kiemeney, Lambertus A. L. M. and Riboli, Elio},
  issn         = {1538-7755},
  language     = {eng},
  number       = {9},
  pages        = {2278--2286},
  publisher    = {American Association for Cancer Research},
  series       = {Cancer Epidemiology Biomarkers & Prevention},
  title        = {Variety in Fruit and Vegetable Consumption and the Risk of Lung Cancer in the European Prospective Investigation into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.1158/1055-9965.EPI-10-0489},
  volume       = {19},
  year         = {2010},
}