Prognosis of aphasia in stroke patients early after iv thrombolysis.
(2013) In Clinical Neurology and Neurosurgery 115(3). p.289-292- Abstract
- OBJECTIVE:
Stroke patients with aphasia have a high long-term morbidity. Intravenous rt-PA (iv) thrombolysis is given more deliberately to these patients. Early outcome data is lacking. Aim of this study was to determine early benefit from rt-PA in patients with aphasia.
METHODS:
Data of stroke patients treated by iv thrombolysis was scrutinized for the presence of aphasia defined as ≥1 point for aphasia on the National Institute of Health Stroke Scale (NIHSS). Improvement was defined as a gain of ≥1 point within 24h. Cranial computed tomography (CT) scans were evaluated regarding early ischemic changes (EICs), infarct volume and localization.
RESULTS:
Fifty patients... (More) - OBJECTIVE:
Stroke patients with aphasia have a high long-term morbidity. Intravenous rt-PA (iv) thrombolysis is given more deliberately to these patients. Early outcome data is lacking. Aim of this study was to determine early benefit from rt-PA in patients with aphasia.
METHODS:
Data of stroke patients treated by iv thrombolysis was scrutinized for the presence of aphasia defined as ≥1 point for aphasia on the National Institute of Health Stroke Scale (NIHSS). Improvement was defined as a gain of ≥1 point within 24h. Cranial computed tomography (CT) scans were evaluated regarding early ischemic changes (EICs), infarct volume and localization.
RESULTS:
Fifty patients with aphasia were included. 16 (32%) of patients improved (4 (36%) minor, 7 (41%) moderate, 5 (23%) major stroke patients), while 44 (62%) remained unchanged. Of 28 patients with EICs, 10 (36%) improved compared to 7 out of 22 (32%) patients without (p=0.773). Aphasia outcome was significantly associated with infarct volume at admission and at 24h (Kruskal-Wallis, p=0.033, p≤0.001, respectively).
CONCLUSION:
EICs are not predictive of aphasia outcome and patients with improvement showed smaller infarct volumes. One third improved within 24h, while two thirds remained unchanged. This might justify a closer follow-up of aphasia in stroke patients at the acute stage. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2858908
- author
- Kremer, Christine LU ; Perren, Fabienne ; Kappelin, Johan ; Selariu, Eufrozina LU and Abul-Kasim, Kasim LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Thrombolysis Stroke Aphasia Outcome
- in
- Clinical Neurology and Neurosurgery
- volume
- 115
- issue
- 3
- pages
- 289 - 292
- publisher
- Elsevier
- external identifiers
-
- wos:000315309200008
- pmid:22738732
- scopus:84873736181
- pmid:22738732
- ISSN
- 1872-6968
- DOI
- 10.1016/j.clineuro.2012.05.019
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Medical Radiology Unit (013241410), Neurology, Malmö (013027010)
- id
- 16b7f714-b609-4940-beab-4a76bac3986b (old id 2858908)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22738732?dopt=Abstract
- date added to LUP
- 2016-04-01 11:16:20
- date last changed
- 2022-01-26 06:46:44
@article{16b7f714-b609-4940-beab-4a76bac3986b,
abstract = {{OBJECTIVE: <br/><br>
Stroke patients with aphasia have a high long-term morbidity. Intravenous rt-PA (iv) thrombolysis is given more deliberately to these patients. Early outcome data is lacking. Aim of this study was to determine early benefit from rt-PA in patients with aphasia. <br/><br>
<br/><br>
METHODS: <br/><br>
Data of stroke patients treated by iv thrombolysis was scrutinized for the presence of aphasia defined as ≥1 point for aphasia on the National Institute of Health Stroke Scale (NIHSS). Improvement was defined as a gain of ≥1 point within 24h. Cranial computed tomography (CT) scans were evaluated regarding early ischemic changes (EICs), infarct volume and localization. <br/><br>
<br/><br>
RESULTS: <br/><br>
Fifty patients with aphasia were included. 16 (32%) of patients improved (4 (36%) minor, 7 (41%) moderate, 5 (23%) major stroke patients), while 44 (62%) remained unchanged. Of 28 patients with EICs, 10 (36%) improved compared to 7 out of 22 (32%) patients without (p=0.773). Aphasia outcome was significantly associated with infarct volume at admission and at 24h (Kruskal-Wallis, p=0.033, p≤0.001, respectively). <br/><br>
<br/><br>
CONCLUSION: <br/><br>
EICs are not predictive of aphasia outcome and patients with improvement showed smaller infarct volumes. One third improved within 24h, while two thirds remained unchanged. This might justify a closer follow-up of aphasia in stroke patients at the acute stage.}},
author = {{Kremer, Christine and Perren, Fabienne and Kappelin, Johan and Selariu, Eufrozina and Abul-Kasim, Kasim}},
issn = {{1872-6968}},
keywords = {{Thrombolysis Stroke Aphasia Outcome}},
language = {{eng}},
number = {{3}},
pages = {{289--292}},
publisher = {{Elsevier}},
series = {{Clinical Neurology and Neurosurgery}},
title = {{Prognosis of aphasia in stroke patients early after iv thrombolysis.}},
url = {{https://lup.lub.lu.se/search/files/2523565/3089224.pdf}},
doi = {{10.1016/j.clineuro.2012.05.019}},
volume = {{115}},
year = {{2013}},
}