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The role of estrogen in the TSH and prolactin responses to thyrotropin-releasing hormone in postmenopausal as compared to premenopausal women

Erfurth, E M LU and Ericsson, U B (1992) In Hormone and Metabolic Research 24(11). p.31-528
Abstract

The basal and TRH (Thyrotropin-Releasing Hormone) stimulated TSH (Thyrotropin) and PRL (Prolactin) responses (incremental area; IA) to 200 micrograms TRH was studied in 13 pre- and 13 postmenopausal women of 60 years of age. Both groups consisted of healthy women, none had goiter and all were negative for thyroid autoantibodies. The serum levels of TSH, T3, T4 and SHBG (sex hormone-binding globuline) were in the normal range and did not differ significantly between the groups. There were no differences in basal TSH (1.3 +/- 0.5 vs 1.4 +/- 0.5 mIU/l) or PRL (6.4 +/- 2.7 vs 6.6 +/- 2.5 micrograms/l) or for PRL IA (498 +/- 126 vs 584 +/- 165) between pre- and postmenopausal women. However, for TSH IA there was a slight decrease (15%), but... (More)

The basal and TRH (Thyrotropin-Releasing Hormone) stimulated TSH (Thyrotropin) and PRL (Prolactin) responses (incremental area; IA) to 200 micrograms TRH was studied in 13 pre- and 13 postmenopausal women of 60 years of age. Both groups consisted of healthy women, none had goiter and all were negative for thyroid autoantibodies. The serum levels of TSH, T3, T4 and SHBG (sex hormone-binding globuline) were in the normal range and did not differ significantly between the groups. There were no differences in basal TSH (1.3 +/- 0.5 vs 1.4 +/- 0.5 mIU/l) or PRL (6.4 +/- 2.7 vs 6.6 +/- 2.5 micrograms/l) or for PRL IA (498 +/- 126 vs 584 +/- 165) between pre- and postmenopausal women. However, for TSH IA there was a slight decrease (15%), but not significant, in the postmenopausal group compared to the premenopausal group (1630 +/- 598 vs 2067 +/- 893). In conclusion, a weak but not significant decrease in the TSH response to TRH in postmenopausal women may be explained by the lower endogenous estradiol level.

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author
and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adult, Estrogens/physiology, Female, Humans, Kinetics, Menopause/physiology, Middle Aged, Prolactin/metabolism, Thyrotropin/metabolism, Thyrotropin-Releasing Hormone
in
Hormone and Metabolic Research
volume
24
issue
11
pages
31 - 528
publisher
Georg Thieme Verlag
external identifiers
  • scopus:0026482841
  • pmid:1452118
ISSN
0018-5043
DOI
10.1055/s-2007-1003381
language
English
LU publication?
no
id
16f90c08-9b23-470d-8554-cc7a19434ad7
date added to LUP
2023-11-27 10:21:21
date last changed
2024-01-10 11:54:28
@article{16f90c08-9b23-470d-8554-cc7a19434ad7,
  abstract     = {{<p>The basal and TRH (Thyrotropin-Releasing Hormone) stimulated TSH (Thyrotropin) and PRL (Prolactin) responses (incremental area; IA) to 200 micrograms TRH was studied in 13 pre- and 13 postmenopausal women of 60 years of age. Both groups consisted of healthy women, none had goiter and all were negative for thyroid autoantibodies. The serum levels of TSH, T3, T4 and SHBG (sex hormone-binding globuline) were in the normal range and did not differ significantly between the groups. There were no differences in basal TSH (1.3 +/- 0.5 vs 1.4 +/- 0.5 mIU/l) or PRL (6.4 +/- 2.7 vs 6.6 +/- 2.5 micrograms/l) or for PRL IA (498 +/- 126 vs 584 +/- 165) between pre- and postmenopausal women. However, for TSH IA there was a slight decrease (15%), but not significant, in the postmenopausal group compared to the premenopausal group (1630 +/- 598 vs 2067 +/- 893). In conclusion, a weak but not significant decrease in the TSH response to TRH in postmenopausal women may be explained by the lower endogenous estradiol level.</p>}},
  author       = {{Erfurth, E M and Ericsson, U B}},
  issn         = {{0018-5043}},
  keywords     = {{Adult; Estrogens/physiology; Female; Humans; Kinetics; Menopause/physiology; Middle Aged; Prolactin/metabolism; Thyrotropin/metabolism; Thyrotropin-Releasing Hormone}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{31--528}},
  publisher    = {{Georg Thieme Verlag}},
  series       = {{Hormone and Metabolic Research}},
  title        = {{The role of estrogen in the TSH and prolactin responses to thyrotropin-releasing hormone in postmenopausal as compared to premenopausal women}},
  url          = {{http://dx.doi.org/10.1055/s-2007-1003381}},
  doi          = {{10.1055/s-2007-1003381}},
  volume       = {{24}},
  year         = {{1992}},
}