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Load and lock: the molecular mechanisms of B-lymphocyte commitment.

Zandi, Sasan; Bryder, David LU and Sigvardsson, Mikael LU (2010) In Immunological Reviews 238(1). p.47-62
Abstract
Summary: The maturation of B-lymphoid cells from hematopoietic stem cells in the bone marrow is a complex process under control of interplay between extrinsic and intrinsic factors. In addition to serving as a model for normal cell differentiation, disturbances in this process results in immunodeficiencies and malignancies, such as leukemia and lymphoma, making the subject of high relevance for modern medicine. Although the process of B lymphopoiesis has been under intense investigation, recent methodological developments within the area of cell sorting, genome-wide expression, and DNA-binding analysis has allowed for a rapid development of the understanding of B-lymphocyte differentiation. This has suggested that the path to B-lymphoid... (More)
Summary: The maturation of B-lymphoid cells from hematopoietic stem cells in the bone marrow is a complex process under control of interplay between extrinsic and intrinsic factors. In addition to serving as a model for normal cell differentiation, disturbances in this process results in immunodeficiencies and malignancies, such as leukemia and lymphoma, making the subject of high relevance for modern medicine. Although the process of B lymphopoiesis has been under intense investigation, recent methodological developments within the area of cell sorting, genome-wide expression, and DNA-binding analysis has allowed for a rapid development of the understanding of B-lymphocyte differentiation. This has suggested that the path to B-lymphoid cell fate may be initiated by lineage priming reflected in the expression of lymphoid associated genes already in multipotent hematopoietic progenitors. Upon differentiation, the gene expression profile is changed to involve an increasing number of B-lineage-restricted genes linked to loss of alternative developmental potentials and B-lineage commitment. This review focuses on the molecular regulation of early B-lymphoid development and aims to provide an up to date summary of the current status of the research area. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Immunological Reviews
volume
238
issue
1
pages
47 - 62
publisher
Munksgaard International Publishers
external identifiers
  • wos:000283509100005
  • pmid:20969584
  • scopus:77958542905
ISSN
1600-065X
DOI
10.1111/j.1600-065X.2010.00950.x
language
English
LU publication?
yes
id
6ad726b3-5e59-43cf-87a7-4f11c5c8ec89 (old id 1710857)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20969584?dopt=Abstract
date added to LUP
2010-11-05 14:12:25
date last changed
2017-01-01 07:42:45
@article{6ad726b3-5e59-43cf-87a7-4f11c5c8ec89,
  abstract     = {Summary: The maturation of B-lymphoid cells from hematopoietic stem cells in the bone marrow is a complex process under control of interplay between extrinsic and intrinsic factors. In addition to serving as a model for normal cell differentiation, disturbances in this process results in immunodeficiencies and malignancies, such as leukemia and lymphoma, making the subject of high relevance for modern medicine. Although the process of B lymphopoiesis has been under intense investigation, recent methodological developments within the area of cell sorting, genome-wide expression, and DNA-binding analysis has allowed for a rapid development of the understanding of B-lymphocyte differentiation. This has suggested that the path to B-lymphoid cell fate may be initiated by lineage priming reflected in the expression of lymphoid associated genes already in multipotent hematopoietic progenitors. Upon differentiation, the gene expression profile is changed to involve an increasing number of B-lineage-restricted genes linked to loss of alternative developmental potentials and B-lineage commitment. This review focuses on the molecular regulation of early B-lymphoid development and aims to provide an up to date summary of the current status of the research area.},
  author       = {Zandi, Sasan and Bryder, David and Sigvardsson, Mikael},
  issn         = {1600-065X},
  language     = {eng},
  number       = {1},
  pages        = {47--62},
  publisher    = {Munksgaard International Publishers},
  series       = {Immunological Reviews},
  title        = {Load and lock: the molecular mechanisms of B-lymphocyte commitment.},
  url          = {http://dx.doi.org/10.1111/j.1600-065X.2010.00950.x},
  volume       = {238},
  year         = {2010},
}