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The genetic structure of Borrelia afzelii varies with geographic but not ecological sampling scale.

Hellgren, Olof LU ; Andersson, Martin LU and Råberg, Lars LU (2011) In Journal of Evolutionary Biology 24. p.159-167
Abstract
The genetic structure of a pathogen is an important determinant of its potential rate of adaptation and can thereby influence the dynamics of host-parasite interactions. We investigated how the genetic structure of Borrelia afzelii varies with geographic and ecological sampling scale. Genetic structure was measured as the degree of linkage disequilibrium (LD) across three loci. To test for the effects of geographic and ecological scale, we calculated LD across or within populations 4-82 km apart and across or within different mammal host species. There was highly significant LD across populations and host species. However, there was also evidence for genome-wide recombination, and the LD largely resulted from epidemic spread of certain... (More)
The genetic structure of a pathogen is an important determinant of its potential rate of adaptation and can thereby influence the dynamics of host-parasite interactions. We investigated how the genetic structure of Borrelia afzelii varies with geographic and ecological sampling scale. Genetic structure was measured as the degree of linkage disequilibrium (LD) across three loci. To test for the effects of geographic and ecological scale, we calculated LD across or within populations 4-82 km apart and across or within different mammal host species. There was highly significant LD across populations and host species. However, there was also evidence for genome-wide recombination, and the LD largely resulted from epidemic spread of certain haplotypes, rather than lack of recombination. Interestingly, the degree of LD was higher in each population than in the sample as a whole, i.e. LD increased with decreasing geographic scale. In contrast, there was no effect of ecological sampling scale on LD. Strong LD may impede the rate of adaptive evolution. Our results suggest this effect might be particularly strong at a small geographic scale. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Evolutionary Biology
volume
24
pages
159 - 167
publisher
John Wiley & Sons
external identifiers
  • wos:000285418500015
  • scopus:78650229545
ISSN
1420-9101
DOI
10.1111/j.1420-9101.2010.02148.x
project
Borrelia in rodents
language
English
LU publication?
yes
id
05c92e1a-016f-44a4-97bf-f5f34a4bfaee (old id 1710896)
date added to LUP
2010-11-22 12:42:16
date last changed
2017-11-05 03:02:26
@article{05c92e1a-016f-44a4-97bf-f5f34a4bfaee,
  abstract     = {The genetic structure of a pathogen is an important determinant of its potential rate of adaptation and can thereby influence the dynamics of host-parasite interactions. We investigated how the genetic structure of Borrelia afzelii varies with geographic and ecological sampling scale. Genetic structure was measured as the degree of linkage disequilibrium (LD) across three loci. To test for the effects of geographic and ecological scale, we calculated LD across or within populations 4-82 km apart and across or within different mammal host species. There was highly significant LD across populations and host species. However, there was also evidence for genome-wide recombination, and the LD largely resulted from epidemic spread of certain haplotypes, rather than lack of recombination. Interestingly, the degree of LD was higher in each population than in the sample as a whole, i.e. LD increased with decreasing geographic scale. In contrast, there was no effect of ecological sampling scale on LD. Strong LD may impede the rate of adaptive evolution. Our results suggest this effect might be particularly strong at a small geographic scale.},
  author       = {Hellgren, Olof and Andersson, Martin and Råberg, Lars},
  issn         = {1420-9101},
  language     = {eng},
  pages        = {159--167},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Evolutionary Biology},
  title        = {The genetic structure of Borrelia afzelii varies with geographic but not ecological sampling scale.},
  url          = {http://dx.doi.org/10.1111/j.1420-9101.2010.02148.x},
  volume       = {24},
  year         = {2011},
}