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Perinatal, maternal, and fetal characteristics of children diagnosed with attention-deficit-hyperactivity disorder: results from a population-based study utilizing the Swedish Medical Birth Register.

Gustafsson, Peik LU and Källén, Karin LU (2011) In Developmental Medicine & Child Neurology 53(3). p.263-268
Abstract
Aim The aim of this study was to evaluate the impact of pre- and perinatal factors on the risk of developing attention-deficit-hyperactivity disorder (ADHD). Method We investigated the medical history of 237 children (206 male; 31 female) from Malmö, Sweden born between 1986 and 1996 and in whom a diagnosis of ADHD (Diagnostic and Statistical Manual of Mental Disorders-IIIR or IV) was subsequently made at the Department of Child and Adolescent Psychiatry, Lund University, and a reference group of 31 775 typically developing children from Malmö using data from the Swedish Medical Birth Register. Results The results of multiple logistic regression analysis revealed that ADHD was significantly associated with a young maternal age (odds ratio... (More)
Aim The aim of this study was to evaluate the impact of pre- and perinatal factors on the risk of developing attention-deficit-hyperactivity disorder (ADHD). Method We investigated the medical history of 237 children (206 male; 31 female) from Malmö, Sweden born between 1986 and 1996 and in whom a diagnosis of ADHD (Diagnostic and Statistical Manual of Mental Disorders-IIIR or IV) was subsequently made at the Department of Child and Adolescent Psychiatry, Lund University, and a reference group of 31 775 typically developing children from Malmö using data from the Swedish Medical Birth Register. Results The results of multiple logistic regression analysis revealed that ADHD was significantly associated with a young maternal age (odds ratio [OR] for 5y increase 0.87; 95% confidence interval [CI] 0.76-0.99), maternal smoking (OR 1.35; 95% CI 1.14-1.60), maternal birthplace in Sweden (OR 2.04; 95% CI 1.45-2.94), and preterm birth <32 weeks (OR 3.05; 95% CI 1.39-6.71), and a male predominance (OR 6.38; 95% CI 4.37-9.32). Apgar scores at 5 minutes below 7 were significantly associated with ADHD in the univariable analysis (OR 2.60; 95% CI 1.15-5.90). The population-attributable fraction of ADHD caused by the perinatal factors studied was estimated to be 2.8%. Interpretation The results indicate that the studied factors constitute weak risk factors for developing ADHD. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Developmental Medicine & Child Neurology
volume
53
issue
3
pages
263 - 268
publisher
John Wiley & Sons
external identifiers
  • wos:000286941600017
  • pmid:20964677
  • scopus:79551538214
ISSN
0012-1622
DOI
10.1111/j.1469-8749.2010.03820.x
language
English
LU publication?
yes
id
35812932-f91d-42bc-9f53-c5804a93d67e (old id 1710909)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20964677?dopt=Abstract
date added to LUP
2010-11-05 15:15:42
date last changed
2017-09-10 03:22:10
@article{35812932-f91d-42bc-9f53-c5804a93d67e,
  abstract     = {Aim The aim of this study was to evaluate the impact of pre- and perinatal factors on the risk of developing attention-deficit-hyperactivity disorder (ADHD). Method We investigated the medical history of 237 children (206 male; 31 female) from Malmö, Sweden born between 1986 and 1996 and in whom a diagnosis of ADHD (Diagnostic and Statistical Manual of Mental Disorders-IIIR or IV) was subsequently made at the Department of Child and Adolescent Psychiatry, Lund University, and a reference group of 31 775 typically developing children from Malmö using data from the Swedish Medical Birth Register. Results The results of multiple logistic regression analysis revealed that ADHD was significantly associated with a young maternal age (odds ratio [OR] for 5y increase 0.87; 95% confidence interval [CI] 0.76-0.99), maternal smoking (OR 1.35; 95% CI 1.14-1.60), maternal birthplace in Sweden (OR 2.04; 95% CI 1.45-2.94), and preterm birth &lt;32 weeks (OR 3.05; 95% CI 1.39-6.71), and a male predominance (OR 6.38; 95% CI 4.37-9.32). Apgar scores at 5 minutes below 7 were significantly associated with ADHD in the univariable analysis (OR 2.60; 95% CI 1.15-5.90). The population-attributable fraction of ADHD caused by the perinatal factors studied was estimated to be 2.8%. Interpretation The results indicate that the studied factors constitute weak risk factors for developing ADHD.},
  author       = {Gustafsson, Peik and Källén, Karin},
  issn         = {0012-1622},
  language     = {eng},
  number       = {3},
  pages        = {263--268},
  publisher    = {John Wiley & Sons},
  series       = {Developmental Medicine & Child Neurology},
  title        = {Perinatal, maternal, and fetal characteristics of children diagnosed with attention-deficit-hyperactivity disorder: results from a population-based study utilizing the Swedish Medical Birth Register.},
  url          = {http://dx.doi.org/10.1111/j.1469-8749.2010.03820.x},
  volume       = {53},
  year         = {2011},
}