Advanced

Standard protocol for assessment of colon cancer improves the quality of pathology.

Buchwald, Pamela; Olofsson, Fredrik; Lörinc, Ester and Syk, Ingvar LU (2011) In Colorectal Disease 13. p.33-36
Abstract
Aim: Tumour stage is the most important prognostic factor in colon cancer. The aim of this study was to examine the impact on the quality of pathology by the use of a standardized PAD protocol. Method: A standardized PAD protocol for colorectal cancer was developed and all patients subjected to colon resection due to adenocarcinomas between 2004 and 2006 were analyzed concerning lymph node status, circumferential resection margin (CRM), intravascular and perineural growth. Moreover, usage of the PAD protocol and whether a pathologist or biomedicine analytic technician (BMA) performed the lymph node dissection was noted and also if the surgical procedure was elective or acute. Results: During the study period 302 colon resections were... (More)
Aim: Tumour stage is the most important prognostic factor in colon cancer. The aim of this study was to examine the impact on the quality of pathology by the use of a standardized PAD protocol. Method: A standardized PAD protocol for colorectal cancer was developed and all patients subjected to colon resection due to adenocarcinomas between 2004 and 2006 were analyzed concerning lymph node status, circumferential resection margin (CRM), intravascular and perineural growth. Moreover, usage of the PAD protocol and whether a pathologist or biomedicine analytic technician (BMA) performed the lymph node dissection was noted and also if the surgical procedure was elective or acute. Results: During the study period 302 colon resections were carried out. The standard protocol was employed in 68% of the cases varying from 0-100% between pathologists. The median number of investigated lymph nodes was 16 ± 11. When the lymph node dissection was performed by a BMA, significantly more lymph nodes were examined; 22 ± 15 and 14 ± 9 respectively (p<0.01). There was a positive correlation between application of the standard protocol and the number of analyzed lymph nodes (<0.05). Comments on CRM, perineural growth and intravascular growth were also significantly more frequent when the protocol was used. Emergency surgery did not influence the handling of the specimens. Conclusion: Minor efforts in terms of a standard protocol for pathology and specimen dissection by BMAs, leading to an increased quality of the PAD-report may also improve long term outcome for patients. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Colorectal Disease
volume
13
pages
33 - 36
publisher
Wiley-Blackwell
external identifiers
  • wos:000287317000001
  • pmid:20958907
  • scopus:79951539767
ISSN
1462-8910
DOI
10.1111/j.1463-1318.2010.02454.x
language
English
LU publication?
yes
id
829e44b2-07d0-4ca4-b8cc-6b46ad8e7f49 (old id 1710994)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20958907?dopt=Abstract
date added to LUP
2010-11-05 14:55:03
date last changed
2017-09-10 04:45:03
@article{829e44b2-07d0-4ca4-b8cc-6b46ad8e7f49,
  abstract     = {Aim: Tumour stage is the most important prognostic factor in colon cancer. The aim of this study was to examine the impact on the quality of pathology by the use of a standardized PAD protocol. Method: A standardized PAD protocol for colorectal cancer was developed and all patients subjected to colon resection due to adenocarcinomas between 2004 and 2006 were analyzed concerning lymph node status, circumferential resection margin (CRM), intravascular and perineural growth. Moreover, usage of the PAD protocol and whether a pathologist or biomedicine analytic technician (BMA) performed the lymph node dissection was noted and also if the surgical procedure was elective or acute. Results: During the study period 302 colon resections were carried out. The standard protocol was employed in 68% of the cases varying from 0-100% between pathologists. The median number of investigated lymph nodes was 16 ± 11. When the lymph node dissection was performed by a BMA, significantly more lymph nodes were examined; 22 ± 15 and 14 ± 9 respectively (p&lt;0.01). There was a positive correlation between application of the standard protocol and the number of analyzed lymph nodes (&lt;0.05). Comments on CRM, perineural growth and intravascular growth were also significantly more frequent when the protocol was used. Emergency surgery did not influence the handling of the specimens. Conclusion: Minor efforts in terms of a standard protocol for pathology and specimen dissection by BMAs, leading to an increased quality of the PAD-report may also improve long term outcome for patients.},
  author       = {Buchwald, Pamela and Olofsson, Fredrik and Lörinc, Ester and Syk, Ingvar},
  issn         = {1462-8910},
  language     = {eng},
  pages        = {33--36},
  publisher    = {Wiley-Blackwell},
  series       = {Colorectal Disease},
  title        = {Standard protocol for assessment of colon cancer improves the quality of pathology.},
  url          = {http://dx.doi.org/10.1111/j.1463-1318.2010.02454.x},
  volume       = {13},
  year         = {2011},
}