Parental history and venous thromboembolism: a nationwide study of age and sex-specific familial risks in Sweden.
(2011) In Journal of Thrombosis and Haemostasis 9(1). p.64-70- Abstract
- Background: The value of parental history as a risk indicator for venous thromboembolism (VTE) has not been determined in a nationwide setting. Objectives: This is the first nationwide study of age and sex specific familial VTE risks in offspring of parents hospitalized for VTE. Patients/Methods: The Swedish Multigeneration Register of 0-75-year-old subjects was linked to the Hospital Discharge Register for 1987-2007. Standardized incidence ratios (SIRs) were calculated for individuals whose parents were hospitalized for VTE compared to those whose parents were unaffected. Results: Among 45,362 hospitalized offspring cases with VTE, 4865 offspring of affected parents were identified with a familial SIR of 2.00 (95% CI 1.94-2.05). Familial... (More)
- Background: The value of parental history as a risk indicator for venous thromboembolism (VTE) has not been determined in a nationwide setting. Objectives: This is the first nationwide study of age and sex specific familial VTE risks in offspring of parents hospitalized for VTE. Patients/Methods: The Swedish Multigeneration Register of 0-75-year-old subjects was linked to the Hospital Discharge Register for 1987-2007. Standardized incidence ratios (SIRs) were calculated for individuals whose parents were hospitalized for VTE compared to those whose parents were unaffected. Results: Among 45,362 hospitalized offspring cases with VTE, 4865 offspring of affected parents were identified with a familial SIR of 2.00 (95% CI 1.94-2.05). Familial SIR was slightly higher for male offspring than for female offspring (2.08, 95% CI 2.00-2.16 vs. 1.91, 95% CI 1.84-1.99). The risk in offspring was further increased when both parents were affected (3.97, 95% CI 3.40-4.61), with high familial risks at ages 20-29 years (10.00, 95% CI 5.91-15.84). The familial risks for VTE among offspring were increased from the age of 10 up to 75 years, with a familial SIR of 3.96 (95% CI 3.13-4.94) at ages 10-19 years and 1.48 (95% CI 1.17-1.84) at age 70-75. However, the absolute incidence rate increased with age. Conclusions: Parental history is potentially useful for risk assessments of VTE, although age needs to be considered. Our results support the use of an age-dependent multicausal model to estimate the risk of VTE. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1711239
- author
- Zöller, Bengt LU ; Li, Xinjun LU ; Sundquist, Jan LU and Sundquist, Kristina LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- venous thrombosis, thromboembolism, venous, risk factors, family history, age, epidemiology
- in
- Journal of Thrombosis and Haemostasis
- volume
- 9
- issue
- 1
- pages
- 64 - 70
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000286055500010
- pmid:20942849
- scopus:78650951814
- pmid:20942849
- ISSN
- 1538-7933
- DOI
- 10.1111/j.1538-7836.2010.04107.x
- language
- English
- LU publication?
- yes
- id
- 0a2c6b77-10d1-4b60-874b-7e025d37454d (old id 1711239)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20942849?dopt=Abstract
- date added to LUP
- 2016-04-01 10:56:28
- date last changed
- 2022-04-12 19:03:29
@article{0a2c6b77-10d1-4b60-874b-7e025d37454d, abstract = {{Background: The value of parental history as a risk indicator for venous thromboembolism (VTE) has not been determined in a nationwide setting. Objectives: This is the first nationwide study of age and sex specific familial VTE risks in offspring of parents hospitalized for VTE. Patients/Methods: The Swedish Multigeneration Register of 0-75-year-old subjects was linked to the Hospital Discharge Register for 1987-2007. Standardized incidence ratios (SIRs) were calculated for individuals whose parents were hospitalized for VTE compared to those whose parents were unaffected. Results: Among 45,362 hospitalized offspring cases with VTE, 4865 offspring of affected parents were identified with a familial SIR of 2.00 (95% CI 1.94-2.05). Familial SIR was slightly higher for male offspring than for female offspring (2.08, 95% CI 2.00-2.16 vs. 1.91, 95% CI 1.84-1.99). The risk in offspring was further increased when both parents were affected (3.97, 95% CI 3.40-4.61), with high familial risks at ages 20-29 years (10.00, 95% CI 5.91-15.84). The familial risks for VTE among offspring were increased from the age of 10 up to 75 years, with a familial SIR of 3.96 (95% CI 3.13-4.94) at ages 10-19 years and 1.48 (95% CI 1.17-1.84) at age 70-75. However, the absolute incidence rate increased with age. Conclusions: Parental history is potentially useful for risk assessments of VTE, although age needs to be considered. Our results support the use of an age-dependent multicausal model to estimate the risk of VTE.}}, author = {{Zöller, Bengt and Li, Xinjun and Sundquist, Jan and Sundquist, Kristina}}, issn = {{1538-7933}}, keywords = {{venous thrombosis; thromboembolism; venous; risk factors; family history; age; epidemiology}}, language = {{eng}}, number = {{1}}, pages = {{64--70}}, publisher = {{Wiley-Blackwell}}, series = {{Journal of Thrombosis and Haemostasis}}, title = {{Parental history and venous thromboembolism: a nationwide study of age and sex-specific familial risks in Sweden.}}, url = {{http://dx.doi.org/10.1111/j.1538-7836.2010.04107.x}}, doi = {{10.1111/j.1538-7836.2010.04107.x}}, volume = {{9}}, year = {{2011}}, }