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QSRR analysis of β-lactam antibiotics on a penicillin G targeted MIP stationary phase.

Kempe, Henrik LU and Kempe, Maria LU (2010) In Analytical and Bioanalytical Chemistry 398(7). p.3087-3096
Abstract
The imprinting factors of the β-lactam antibiotics penicillin V, methicillin, nafcillin, oxacillin, cloxacillin, dicloxacillin, and piperacillin on a poly(methacrylic acid-co-trimethylolpropane trimethacrylate) molecularly imprinted stationary phase targeted for penicillin G were correlated with molecular descriptors obtained by molecular computation. One-parameter linear regression and multivariate data analysis by principal component analysis and partial least square regression indicated that descriptors associated with molecular topology, shape, size, and volume were highly correlated with the imprinting factor and influential on the derived models.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Analytical and Bioanalytical Chemistry
volume
398
issue
7
pages
3087 - 3096
publisher
Springer
external identifiers
  • wos:000284542300036
  • pmid:20936264
  • scopus:78650169843
ISSN
1618-2642
DOI
10.1007/s00216-010-4254-y
language
English
LU publication?
yes
id
9ed36228-ba76-4df9-8c61-8c61d8a19dc3 (old id 1711318)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20936264?dopt=Abstract
date added to LUP
2010-11-05 09:38:32
date last changed
2018-05-29 10:11:52
@article{9ed36228-ba76-4df9-8c61-8c61d8a19dc3,
  abstract     = {The imprinting factors of the β-lactam antibiotics penicillin V, methicillin, nafcillin, oxacillin, cloxacillin, dicloxacillin, and piperacillin on a poly(methacrylic acid-co-trimethylolpropane trimethacrylate) molecularly imprinted stationary phase targeted for penicillin G were correlated with molecular descriptors obtained by molecular computation. One-parameter linear regression and multivariate data analysis by principal component analysis and partial least square regression indicated that descriptors associated with molecular topology, shape, size, and volume were highly correlated with the imprinting factor and influential on the derived models.},
  author       = {Kempe, Henrik and Kempe, Maria},
  issn         = {1618-2642},
  language     = {eng},
  number       = {7},
  pages        = {3087--3096},
  publisher    = {Springer},
  series       = {Analytical and Bioanalytical Chemistry},
  title        = {QSRR analysis of β-lactam antibiotics on a penicillin G targeted MIP stationary phase.},
  url          = {http://dx.doi.org/10.1007/s00216-010-4254-y},
  volume       = {398},
  year         = {2010},
}