Advanced

Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study

Campa, Daniele; Pardini, Barbara; Naccarati, Alessio; Vodickova, Ludmila; Novotny, Jan; Steinke, Verena; Rahner, Nils; Holinski-Feder, Elke; Morak, Monika and Schackert, Hans K., et al. (2010) In BMC Gastroenterology 10.
Abstract
Background: Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor (GHSR), has two major functions: the stimulation of the growth hormone production and the stimulation of food intake. Accumulating evidence also indicates a role of ghrelin in cancer development. Methods: We conducted a case-control study to examine the association of common genetic variants in the genes coding for ghrelin (GHRL) and its receptor (GHSR) with colorectal cancer risk. Pairwise tagging was used to select the 11 polymorphisms included in the study. The selected polymorphisms were genotyped in 680 cases and 593 controls from the Czech Republic. Results: We found two SNPs associated with lower risk of colorectal cancer, namely SNPs rs27647 and... (More)
Background: Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor (GHSR), has two major functions: the stimulation of the growth hormone production and the stimulation of food intake. Accumulating evidence also indicates a role of ghrelin in cancer development. Methods: We conducted a case-control study to examine the association of common genetic variants in the genes coding for ghrelin (GHRL) and its receptor (GHSR) with colorectal cancer risk. Pairwise tagging was used to select the 11 polymorphisms included in the study. The selected polymorphisms were genotyped in 680 cases and 593 controls from the Czech Republic. Results: We found two SNPs associated with lower risk of colorectal cancer, namely SNPs rs27647 and rs35683. We replicated the two hits, in additional 569 cases and 726 controls from Germany. Conclusion: A joint analysis of the two populations indicated that the T allele of rs27647 SNP exerted a protective borderline effect (P-trend = 0.004). (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
BMC Gastroenterology
volume
10
publisher
BMC Biomedical Centre, Lund University
external identifiers
  • wos:000282779500001
  • scopus:77957116442
ISSN
1471-230X
DOI
10.1186/1471-230X-10-112
language
English
LU publication?
yes
id
75858fd3-7989-4730-8ead-5a77d9e4d524 (old id 1726189)
date added to LUP
2010-12-03 11:31:56
date last changed
2018-05-29 11:10:01
@article{75858fd3-7989-4730-8ead-5a77d9e4d524,
  abstract     = {Background: Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor (GHSR), has two major functions: the stimulation of the growth hormone production and the stimulation of food intake. Accumulating evidence also indicates a role of ghrelin in cancer development. Methods: We conducted a case-control study to examine the association of common genetic variants in the genes coding for ghrelin (GHRL) and its receptor (GHSR) with colorectal cancer risk. Pairwise tagging was used to select the 11 polymorphisms included in the study. The selected polymorphisms were genotyped in 680 cases and 593 controls from the Czech Republic. Results: We found two SNPs associated with lower risk of colorectal cancer, namely SNPs rs27647 and rs35683. We replicated the two hits, in additional 569 cases and 726 controls from Germany. Conclusion: A joint analysis of the two populations indicated that the T allele of rs27647 SNP exerted a protective borderline effect (P-trend = 0.004).},
  author       = {Campa, Daniele and Pardini, Barbara and Naccarati, Alessio and Vodickova, Ludmila and Novotny, Jan and Steinke, Verena and Rahner, Nils and Holinski-Feder, Elke and Morak, Monika and Schackert, Hans K. and Goergens, Heike and Koetting, Judith and Betz, Beate and Kloor, Matthias and Engel, Christoph and Buettner, Reinhard and Propping, Peter and Försti, Asta and Hemminki, Kari and Barale, Roberto and Vodicka, Pavel and Canzian, Federico},
  issn         = {1471-230X},
  language     = {eng},
  publisher    = {BMC Biomedical Centre, Lund University},
  series       = {BMC Gastroenterology},
  title        = {Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study},
  url          = {http://dx.doi.org/10.1186/1471-230X-10-112},
  volume       = {10},
  year         = {2010},
}