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Antioxidant airway responses following experimental exposure to wood smoke in man

Sehlstedt, Maria; Dove, Rosamund; Boman, Christoffer; Pagels, Joakim LU ; Swietlicki, Erik LU ; Löndahl, Jakob LU ; Westerholm, Roger; Bosson, Jenny; Barath, Stefan and Behndig, Annelie F., et al. (2010) In Particle and Fibre Toxicology 7.
Abstract
Background: Biomass combustion contributes to the production of ambient particulate matter (PM) in rural environments as well as urban settings, but relatively little is known about the health effects of these emissions. The aim of this study was therefore to characterize airway responses in humans exposed to wood smoke PM under controlled conditions. Nineteen healthy volunteers were exposed to both wood smoke, at a particulate matter (PM2.5) concentration of 224 +/- 22 mu g/m(3), and filtered air for three hours with intermittent exercise. The wood smoke was generated employing an experimental set-up with an adjustable wood pellet boiler system under incomplete combustion. Symptoms, lung function, and exhaled NO were measured over... (More)
Background: Biomass combustion contributes to the production of ambient particulate matter (PM) in rural environments as well as urban settings, but relatively little is known about the health effects of these emissions. The aim of this study was therefore to characterize airway responses in humans exposed to wood smoke PM under controlled conditions. Nineteen healthy volunteers were exposed to both wood smoke, at a particulate matter (PM2.5) concentration of 224 +/- 22 mu g/m(3), and filtered air for three hours with intermittent exercise. The wood smoke was generated employing an experimental set-up with an adjustable wood pellet boiler system under incomplete combustion. Symptoms, lung function, and exhaled NO were measured over exposures, with bronchoscopy performed 24 h post-exposure for characterisation of airway inflammatory and antioxidant responses in airway lavages. Results: Glutathione (GSH) concentrations were enhanced in bronchoalveolar lavage (BAL) after wood smoke exposure vs. air (p = 0.025), together with an increase in upper airway symptoms. Neither lung function, exhaled NO nor systemic nor airway inflammatory parameters in BAL and bronchial mucosal biopsies were significantly affected. Conclusions: Exposure of healthy subjects to wood smoke, derived from an experimental wood pellet boiler operating under incomplete combustion conditions with PM emissions dominated by organic matter, caused an increase in mucosal symptoms and GSH in the alveolar respiratory tract lining fluids but no acute airway inflammatory responses. We contend that this response reflects a mobilisation of GSH to the air-lung interface, consistent with a protective adaptation to the investigated wood smoke exposure. (Less)
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Particle and Fibre Toxicology
volume
7
publisher
BioMed Central
external identifiers
  • wos:000282501800001
  • scopus:77955693837
ISSN
1743-8977
DOI
10.1186/1743-8977-7-21
language
English
LU publication?
yes
id
6cd169aa-02bc-4fb7-8c88-1bad2ce8e165 (old id 1726845)
date added to LUP
2010-12-01 14:42:11
date last changed
2018-05-29 10:44:57
@article{6cd169aa-02bc-4fb7-8c88-1bad2ce8e165,
  abstract     = {Background: Biomass combustion contributes to the production of ambient particulate matter (PM) in rural environments as well as urban settings, but relatively little is known about the health effects of these emissions. The aim of this study was therefore to characterize airway responses in humans exposed to wood smoke PM under controlled conditions. Nineteen healthy volunteers were exposed to both wood smoke, at a particulate matter (PM2.5) concentration of 224 +/- 22 mu g/m(3), and filtered air for three hours with intermittent exercise. The wood smoke was generated employing an experimental set-up with an adjustable wood pellet boiler system under incomplete combustion. Symptoms, lung function, and exhaled NO were measured over exposures, with bronchoscopy performed 24 h post-exposure for characterisation of airway inflammatory and antioxidant responses in airway lavages. Results: Glutathione (GSH) concentrations were enhanced in bronchoalveolar lavage (BAL) after wood smoke exposure vs. air (p = 0.025), together with an increase in upper airway symptoms. Neither lung function, exhaled NO nor systemic nor airway inflammatory parameters in BAL and bronchial mucosal biopsies were significantly affected. Conclusions: Exposure of healthy subjects to wood smoke, derived from an experimental wood pellet boiler operating under incomplete combustion conditions with PM emissions dominated by organic matter, caused an increase in mucosal symptoms and GSH in the alveolar respiratory tract lining fluids but no acute airway inflammatory responses. We contend that this response reflects a mobilisation of GSH to the air-lung interface, consistent with a protective adaptation to the investigated wood smoke exposure.},
  author       = {Sehlstedt, Maria and Dove, Rosamund and Boman, Christoffer and Pagels, Joakim and Swietlicki, Erik and Löndahl, Jakob and Westerholm, Roger and Bosson, Jenny and Barath, Stefan and Behndig, Annelie F. and Pourazar, Jamshid and Sandstrom, Thomas and Mudway, Ian S. and Blomberg, Anders},
  issn         = {1743-8977},
  language     = {eng},
  publisher    = {BioMed Central},
  series       = {Particle and Fibre Toxicology},
  title        = {Antioxidant airway responses following experimental exposure to wood smoke in man},
  url          = {http://dx.doi.org/10.1186/1743-8977-7-21},
  volume       = {7},
  year         = {2010},
}