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Reproductive Factors and Exogenous Hormone Use in Relation to Risk of Glioma and Meningioma in a Large European Cohort Study

Michaud, Dominique S.; Gallo, Valentina; Schlehofer, Brigitte; Tjonneland, Anne; Olsen, Anja; Overvad, Kim; Dahm, Christina C.; Kaaks, Rudolf; Lukanova, Annekatrin and Boeing, Heiner, et al. (2010) In Cancer Epidemiology Biomarkers & Prevention 19(10). p.2562-2569
Abstract
Background: The etiologies of glioma and meningioma tumors are largely unknown. Although reproductive hormones are thought to influence the risk of these tumors, epidemiologic data are not supportive of this hypothesis; however, few cohort studies have published on this topic. We examined the relation between reproductive factors and the risk of glioma and meningioma among women in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: After a mean of 8.4 years of follow-up, 193 glioma and 194 meningioma cases were identified among 276,212 women. Information on reproductive factors and hormone use was collected at baseline. Cox proportional hazard regression was used to determine hazard ratios (HR) and 95%... (More)
Background: The etiologies of glioma and meningioma tumors are largely unknown. Although reproductive hormones are thought to influence the risk of these tumors, epidemiologic data are not supportive of this hypothesis; however, few cohort studies have published on this topic. We examined the relation between reproductive factors and the risk of glioma and meningioma among women in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: After a mean of 8.4 years of follow-up, 193 glioma and 194 meningioma cases were identified among 276,212 women. Information on reproductive factors and hormone use was collected at baseline. Cox proportional hazard regression was used to determine hazard ratios (HR) and 95% confidence intervals (95% CI). Results: No associations were observed between glioma or meningioma risk and reproductive factors, including age at menarche, parity, age at first birth, menopausal status, and age at menopause. A higher risk of meningioma was observed among postmenopausal women who were current users of hormone replacement therapy (HR, 1.79; 95% CI, 1.18-2.71) compared with never users. Similarly, current users of oral contraceptives were at higher risk of meningioma than never users (HR, 3.61; 95% CI, 1.75-7.46). Conclusion: Our results do not support a role for estrogens and glioma risk. Use of exogenous hormones, especially current use, seems to increase meningioma risk. However, these findings could be due to diagnostic bias and require confirmation. Impact: Elucidating the role of hormones in brain tumor development has important implications and needs to be further examined using biological measurements. Cancer Epidemiol Biomarkers Prev; 19(10); 2562-9. (C) 2010 AACR. (Less)
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Cancer Epidemiology Biomarkers & Prevention
volume
19
issue
10
pages
2562 - 2569
publisher
American Association for Cancer Research
external identifiers
  • wos:000282590500018
  • scopus:77958069027
ISSN
1538-7755
DOI
10.1158/1055-9965.EPI-10-0447
language
English
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yes
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874d932e-f7c9-4608-9f80-4e3e1411d4d2 (old id 1728046)
date added to LUP
2010-11-23 09:15:09
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2018-06-24 03:57:36
@article{874d932e-f7c9-4608-9f80-4e3e1411d4d2,
  abstract     = {Background: The etiologies of glioma and meningioma tumors are largely unknown. Although reproductive hormones are thought to influence the risk of these tumors, epidemiologic data are not supportive of this hypothesis; however, few cohort studies have published on this topic. We examined the relation between reproductive factors and the risk of glioma and meningioma among women in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: After a mean of 8.4 years of follow-up, 193 glioma and 194 meningioma cases were identified among 276,212 women. Information on reproductive factors and hormone use was collected at baseline. Cox proportional hazard regression was used to determine hazard ratios (HR) and 95% confidence intervals (95% CI). Results: No associations were observed between glioma or meningioma risk and reproductive factors, including age at menarche, parity, age at first birth, menopausal status, and age at menopause. A higher risk of meningioma was observed among postmenopausal women who were current users of hormone replacement therapy (HR, 1.79; 95% CI, 1.18-2.71) compared with never users. Similarly, current users of oral contraceptives were at higher risk of meningioma than never users (HR, 3.61; 95% CI, 1.75-7.46). Conclusion: Our results do not support a role for estrogens and glioma risk. Use of exogenous hormones, especially current use, seems to increase meningioma risk. However, these findings could be due to diagnostic bias and require confirmation. Impact: Elucidating the role of hormones in brain tumor development has important implications and needs to be further examined using biological measurements. Cancer Epidemiol Biomarkers Prev; 19(10); 2562-9. (C) 2010 AACR.},
  author       = {Michaud, Dominique S. and Gallo, Valentina and Schlehofer, Brigitte and Tjonneland, Anne and Olsen, Anja and Overvad, Kim and Dahm, Christina C. and Kaaks, Rudolf and Lukanova, Annekatrin and Boeing, Heiner and Schuetze, Madlen and Trichopoulou, Antonia and Bamia, Christina and Kyrozis, Andreas and Sacerdote, Carlotta and Agnoli, Claudia and Palli, Domenico and Tumino, Rosario and Mattiello, Amalia and Bueno-de-Mesquita, H. Bas and Ros, Martine M. and Peeters, Petra H. M. and van Gils, Carla H. and Lund, Eiliv and Bakken, Kjersti and Gram, Inger T. and Barricarte, Aurelio and Navarro, Carmen and Dorronsoro, Miren and Jose Sanchez, Maria and Rodriguez, Laudina and Duell, Eric J. and Hallmans, Goran and Melin, Beatrice S. and Manjer, Jonas and Borgquist, Signe and Khaw, Kay-Tee and Wareham, Nick and Allen, Naomi E. and Tsilidis, Konstantinos K. and Romieu, Isabelle and Rinaldi, Sabina and Vineis, Paolo and Riboli, Elio},
  issn         = {1538-7755},
  language     = {eng},
  number       = {10},
  pages        = {2562--2569},
  publisher    = {American Association for Cancer Research},
  series       = {Cancer Epidemiology Biomarkers & Prevention},
  title        = {Reproductive Factors and Exogenous Hormone Use in Relation to Risk of Glioma and Meningioma in a Large European Cohort Study},
  url          = {http://dx.doi.org/10.1158/1055-9965.EPI-10-0447},
  volume       = {19},
  year         = {2010},
}